Radiotherapy of brain tumours: Reduced irradiation of normal brain

Kaushal, Vivek; Bidmead, M.; Hill, Lawrence T.; Brada, Michael

doi:10.1016/s0936-6555(05)80997-5

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Improvements In the Technique Of Radiation Delivery1

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2003

2004

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Cited by 2 publications

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“…Linear accelerator beams can be shaped with lead alloy blocks mounted onto an external tray or by altering the shape of the aperture at linear accelerator head with a multileaf collimator (MLC). This results in the reduction in volume of normal brain receiving high doses of radiation when compared to square or rectangular beams (Kaushal et al ., 1990). The available MLCs consist of individual leaves of 3 mm (micro‐MLC), 5 mm (mini‐MLC) and 10 mm (conventional) width.…”

Section: Improvements In the Technique Of Radiation Deliverymentioning

confidence: 99%

Radiosurgery for pituitary adenomas

Brada

Ajithkumar

Minniti

2004

Clinical Endocrinology

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Section: Improvements In the Technique Of Radiation Deliverymentioning

confidence: 99%

Radiosurgery for pituitary adenomas

Brada

Ajithkumar

Minniti

2004

Clinical Endocrinology

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Andersen

2003

Journal of Neuro-Oncology

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Delayed structural cerebral sequelae has been reported following cranial radiation therapy (CRT) to children with primary brain tumors, but little is known about potential functional changes. Twenty-four patients were included, diagnosed and treated at a median age of 11 years, and examined after a median recurrence free survival of 16 years by MRI and Positron Emission Tomography using the glucose analog 2-18F-fluoro-2-deoxy-D-glucose (18FDG). Three patients were not analyzed further due to diffuse cerebral atrophy, which might be related to previous hydrocephalus. Twenty-one patients were evaluable and regional cerebral metabolic rate for glucose (rCMRglc) was estimated in nontumoral brain regions in 12 patients treated with surgery alone and 9 patients treated with both surgery and CRT. Furthermore 10 normal controls matched for age at examination were included. Patients treated with both surgery and CRT had a general decreased rCMRglc compared to normal controls and patients treated with surgery alone, significantly (p < 0.05) in 5 of 11 regions of interest. No difference was found in rCMRglc between normal controls and patients treated with surgery alone. We conclude that there is a general reduction in rCMRglc in long-term recurrence free survivors of childhood primary brain tumors treated with CRT in high doses (44-56 Gy).

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Radiotherapy of brain tumours: Reduced irradiation of normal brain

Cited by 2 publications

References 14 publications

Radiosurgery for pituitary adenomas

Radiosurgery for pituitary adenomas

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