Radix Astragali polysaccharide RAP directly protects hematopoietic stem cells from chemotherapy-induced myelosuppression by increasing FOS expression

Bao, Wan-Rong; Zhang, Quanwei; Hai, Zheng; Li, Lifeng; Liu, Man; Cheng, Ho Ming; Wong, Tin-Long; Zhang, Ge; Lü, Aiping; Bian, Zhaoxiang; Ma, Dik‐Lung; Leung, Chung‐Hang; Han, Quan‐Bin

doi:10.1016/j.ijbiomac.2021.05.120

Cited by 19 publications

(10 citation statements)

References 26 publications

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“…But due to the lack of easily detectable light-emitting groups, further research on polysaccharides has always been hindered. Wanrong Bao et al connected FITC to RAP, and observed that FITC-RAP could directly combine with hematopoietic stem cells (HSC) in bone marrow [ 28 ]. So, on the basis of the above work, we tried to synthesize MCP2-Tyr-FITC as probes in order to further clarify and the mechanism of polysaccharides on CD4 + T cells.…”

Section: Discussionmentioning

confidence: 99%

Extraction of polysaccharides from Maca enhances the treatment effect of 5-FU by regulating CD4+T cells

Cao¹,

Zhang²,

Yan

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Extraction of polysaccharides from Maca enhances the treatment effect of 5-FU by regulating CD4+T cells

Cao¹,

Zhang²,

Yan

et al. 2023

Heliyon

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“…The monosaccharide compositions of these polysaccharides mainly include mannose (Man), rhamnose (Rha), glucose (Glc), galactose (Gal), xylose (Xyl), arabinose (Ara), fucose (Fuc), fructose (Fru), and ribose (Rib), and only a small fraction of APS contains glucuronic acid (GlcA) and galacturonic acid (GalA) [ 12 ]. Pharmacological studies revealed that APS had anti-atherosclerosis [ 13 , 14 ], anti-inflammatory [ 15 , 16 , 17 ], anti-diabetes [ 18 , 19 , 20 , 21 ], antioxidative [ 22 , 23 , 24 ], immunomodulatory [ 25 , 26 , 27 , 28 ], antitumor [ 29 , 30 , 31 , 32 ], and antiviral [ 33 , 34 , 35 ] effects. Although the pharmacological effects of APS have been extensively studied, most of them focus on immune modulating, antitumor and anti-diabetes.…”

Section: Introductionmentioning

confidence: 99%

Purification, Structural Analysis and Cardio-Protective Activity of Polysaccharides from Radix Astragali

Wang,

Peng,

Zhuang

et al. 2023

Molecules

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Two polysaccharides, named APS2-I and APS3-I, were purified from the water extract of Radix Astragali. The average molecular weight of APS2-I was 1.96 × 106 Da and composed of Man, Rha, GlcA, GalA, Glc, Gal, Xyl, and Ara in a molar ratio of 2.3:4.8:1.7:14.0:5.8:11.7:2.8:12.6, while the average molecular weight of APS3-I was 3.91 × 106 Da and composed of Rha, GalA, Glc, Gal, and Ara in a molar ratio of 0.8:2.3:0.8:2.3:4.1. Biological evaluation showed APS2-I and APS3-I had significant antioxidant activity and myocardial protection activity. Furthermore, total polysaccharide treatment could significantly enhance hemodynamic parameters and improve cardiac function in rat ischemia and reperfusion isolated heart models. These results provided important information for the clinical application of APS in the field of cardiovascular disease and implied that Astragalus polysaccharides (APS) could be considered as a reference for the quality control of Radix Astragali.

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“…In addition, RAP significantly reduced the toxic effects of taxol on immune cells (Bao et al, 2018). RAP was shown to enhance recovery after cyclophosphamide-induced myelosuppression by increasing FOS expression (Bao et al, 2021). However, the effect of RAP on functional recovery after PNI has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Radix Astragalus Polysaccharide Accelerates Angiogenesis by Activating AKT/eNOS to Promote Nerve Regeneration and Functional Recovery

et al. 2022

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Peripheral nerve injury (PNI) results in loss of neural control and severe disabilities in patients. Promoting functional nerve recovery by accelerating angiogenesis is a promising neuroprotective treatment strategy. Here, we identified a bioactive Radix Astragalus polysaccharide (RAP) extracted from traditional Chinese medicine (TCM) as a potent enhancer of axonal regeneration and remyelination. Notably, RAP promoted functional recovery and delayed gastrocnemius muscle atrophy in a rat model of sciatic nerve crush injury. Further, RAP treatment may induce angiogenesis in vivo. Moreover, our in vitro results showed that RAP promotes endothelial cell (EC) migration and tube formation. Altogether, our results show that RAP can enhance functional recovery by accelerating angiogenesis, which was probably related to the activation of AKT/eNOS signaling pathway, thereby providing a polysaccharide-based therapeutic strategy for PNI.

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Radix Astragali polysaccharide RAP directly protects hematopoietic stem cells from chemotherapy-induced myelosuppression by increasing FOS expression

Cited by 19 publications

References 26 publications

Extraction of polysaccharides from Maca enhances the treatment effect of 5-FU by regulating CD4+T cells

Extraction of polysaccharides from Maca enhances the treatment effect of 5-FU by regulating CD4+T cells

Purification, Structural Analysis and Cardio-Protective Activity of Polysaccharides from Radix Astragali

Radix Astragalus Polysaccharide Accelerates Angiogenesis by Activating AKT/eNOS to Promote Nerve Regeneration and Functional Recovery

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