Radix Scrophulariae Extracts Exert Effect on Hyperthyroidism via MST1/Hippo Signaling Pathway

Zhang, Ning; Ye, Tao; Lu, Xu; Li, Zi-hui; Li, Ling

doi:10.1007/s11655-023-3744-7

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…This reduction is attributed to the induction of autophagy in breast and prostate cancer cells, respectively (Xiang et al, 2022 ; Zhong et al, 2022 ). Finally, the extract of the plant Radix scrophulariae has recently been shown to inhibit thyroid growth in a rat-hyperthyroidism model, through MST-LATS1-dependent autophagy activation (Zhang et al, 2023 ).…”

Section: Loss Of Proteostasis and Disabled Macroautophagymentioning

confidence: 99%

The NDR family of kinases: essential regulators of aging

Jonischkies,

del Angel,

Demiray

et al. 2024

Front. Mol. Neurosci.

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Aging is defined as a progressive decline of cognitive and physiological functions over lifetime. Since the definition of the nine hallmarks of aging in 2013 by López-Otin, numerous studies have attempted to identify the main regulators and contributors in the aging process. One interesting group of proteins whose participation has been implicated in several aging hallmarks are the nuclear DBF2-related (NDR) family of serine-threonine AGC kinases. They are one of the core components of the Hippo signaling pathway and include NDR1, NDR2, LATS1 and LATS2 in mammals, along with its highly conserved metazoan orthologs; Trc in Drosophila melanogaster, SAX-1 in Caenorhabditis elegans, CBK1, DBF20 in Saccharomyces cerevisiae and orb6 in Saccharomyces pombe. These kinases have been independently linked to the regulation of widely diverse cellular processes disrupted during aging such as the cell cycle progression, transcription, intercellular communication, nutrient homeostasis, autophagy, apoptosis, and stem cell differentiation. However, a comprehensive overview of the state-of-the-art knowledge regarding the post-translational modifications of and by NDR kinases in aging has not been conducted. In this review, we summarize the current understanding of the NDR family of kinases, focusing on their relevance to various aging hallmarks, and emphasize the growing body of evidence that suggests NDR kinases are essential regulators of aging across species.

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Section: Loss Of Proteostasis and Disabled Macroautophagymentioning

confidence: 99%

The NDR family of kinases: essential regulators of aging

Jonischkies,

del Angel,

Demiray

et al. 2024

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Extensive research has demonstrated the anti-inflammatory, antioxidant, anticancer, antibacterial, antiviral, and antiallergic effects of these glycosides [ 6 ]. Previous studies have indicated the potential of R. Scrophulariae for the management of hyperthyroidism [ 7 , 8 ], but further investigations are crucial for comprehensively comprehending the specific substances and mechanisms involved.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic and proteomic investigations identify PI3K-akt pathway targets for hyperthyroidism management in rats via polar iridoids from radix Scrophularia

Zhang,

Liu,

et al. 2024

Heliyon

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Radix Scrophulariae Extracts Exert Effect on Hyperthyroidism via MST1/Hippo Signaling Pathway

Cited by 2 publications

References 25 publications

The NDR family of kinases: essential regulators of aging

The NDR family of kinases: essential regulators of aging

Transcriptomic and proteomic investigations identify PI3K-akt pathway targets for hyperthyroidism management in rats via polar iridoids from radix Scrophularia

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