Abstract.A Compton camera has been suggested for use in single photon emission computed tomography because a conventional gamma camera has low efficiency. Here we consider a cone transform brought about by a Compton camera with line detectors. A cone transform takes a given function on the 3-dimensional space and assigns to it the surface integral of the function over cones determined by the 1-dimensional vertex space, the 1-dimensional central axis, and the 1-dimensional opening angle. We generalize this cone transform to n-dimensional space and provide an inversion formula. Also, numerical simulations are presented to demonstrate our suggested algorithm in three dimensions.Key words. Compton camera, SPECT, tomography, cone transform, inversion, gamma camera AMS subject classifications. 44A12, 65R10, 92C55DOI. 10.1137/15M10336171. Introduction. A Radon-type transform that assigns to a given function its surface integral over various sets of cones has been studied, since it is known that this kind of a transform relates to a Compton camera. A Compton camera, also called an electronically collimated γ-camera, was introduced for use in single photon emission computed tomography (SPECT) because of the low efficiency of a conventional γ-camera [26,32]. A Compton camera has very high sensitivity and flexibility of geometrical design, so it has attracted a lot of interest and applications in many areas including monitoring nuclear power plants and astronomy [1,3].A standard Compton camera consists of two planar detectors: a scatter detector and an absorption detector, positioned one behind the other. A photon emitted from a radioactive source toward the camera undergoes Compton scattering in the scatter detector, and is absorbed in the absorption detector positioned behind (see Figure 1). In each detector, the position of the hit and the energy of the photon are measured. The scattering angle or the