Radyasyona Maruz Bırakılmış Sıçanlarda Spermatozoa Özellikleri ve Testislerde Yarattığı Hasar Üzerine Vitamin C’nin Koruyucu Rolü

Taş, Muzaffer; Cirit, Ümüt; Özkan, Oktay; Denli, Muzaffer; Zincircioglu, Seyit Burhanedtin; Şeker, Uğur; Özmen, Mehmet Ferit; Eren, Leyla Bilge

doi:10.9775/kvfd.2013.9445

Cited by 2 publications

(2 citation statements)

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“…This study shows that the radioprotective agent (vitamin C) acted effectively when the samples were subjected to X-rays and γ (Taş et al, 2014). In addition, it decreased DNA damage in testicular tissues and the preservation of genetic material (Marjault and Allemand, 2016).…”

Section: Comparison Between Foci In γ and X-rays (Control And Vitamin C Groups) To Detect Dsb In Dna By γ-H2axmentioning

confidence: 73%

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EVALUATION THE ROLE OF VITAMIN C AS a RADIATION PROTECTIVE AGENT USING Γ-H2ax FOR SIGNALING OF DNA DAMAGE ON IRRADIATED MICE TESTIS

Alani¹,

Almusawi²,

Mahdi³

2020

PTQ

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An interesting feature of ionizing radiation, especially Gamma and X-rays as a DNA damaging factor is the range of lesions it induces. γ-H2AX foci are documented to represent DNA double-strand breaks (DSBs) as a biomarker for radiation-induced damage. Study design 42 adult male mice Albino BALB/c, had been divided randomly into 6 groups of seven mice each. Group 1 received a standard saline solution untreated also, do not expose to radiation. Group 2 mice received vitamin C (VC) (200 mg/kg.day) intra-peritoneal (i.p.) injected for 8 days without radiation. Group 3 control was exposed to γ-radiation. Group 4 control was exposed to X-ray radiation. Group 5 mice had been administrated with vitamin C in the identical dose of group 2 for 8 days, then exposed to (4 Gy) of γ-ray. Group 6 was administrated with vitamin dose in the same above and the same period, then exposed to (4 Gy) of X-ray. All groups had been sacrificed by cervical dislocation at (1, 3, and 24 h). Post radiation testis mice tissues were collected. A significant difference (P 0.05) between the group of vitamin C and with a control group exposed to both (γ, X-rays) in foci forming, but there is no significant difference (P 0.05) between γ and X- rays for the control and vitamin C groups. The results demonstrate that vitamin C is a good radioprotective agent for testis mice tissues; the effect of (γ and X-rays) had almost the same results on the mice testicle tissues with the same dose.

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Section: Comparison Between Foci In γ and X-rays (Control And Vitamin C Groups) To Detect Dsb In Dna By γ-H2axmentioning

confidence: 73%

“…Unlike most mammals, humans do not have the capacity to produce vitamin C. Therefore, and it must be obtained through food (Taş et al, 2014). However, in vitro experiments reveal that vitamin C has many functions (Farag et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

EVALUATION THE ROLE OF VITAMIN C AS a RADIATION PROTECTIVE AGENT USING Γ-H2ax FOR SIGNALING OF DNA DAMAGE ON IRRADIATED MICE TESTIS

Alani¹,

Almusawi²,

Mahdi³

2020

PTQ

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Effects of antioxidant diet on the RBC indices in fructose-induced obesity rat model

Bakalov

Sabit

Tafradjiiska

et al. 2021

Acta Scientifica Naturalis

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The oxidative stress is one of the known and discussed culprits for development and progression of the disturbances in Metabolic syndrome (MetS). In our study, we are investigating the effects of antioxidant additives as additional treatment and prophylaxis in a model of MetS. We are using a fructose-induced metabolic syndrome rat model to examine the effects of antioxidant preparation ZellSchutz. Four experimental groups were formed using male Wistar rats (n = 60). The control group received standard rat chow, the other groups received either ZellSchutz (Z), fructose (F), or fructose and ZellSchutz (ZF). Our results showed an unexpected increase in the RBC indices in rats with dual treatment. There was a significant increase in hemoglobin concentration, MCHC, and MCV in those animals (p<0.001). The preliminary data shows the important role of antioxidants as supplementary therapy in metabolic syndrome. Further investigations will be carried on to reveal the molecular mechanisms of the observed changes.

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Radyasyona Maruz Bırakılmış Sıçanlarda Spermatozoa Özellikleri ve Testislerde Yarattığı Hasar Üzerine Vitamin C’nin Koruyucu Rolü

Cited by 2 publications

References 20 publications

EVALUATION THE ROLE OF VITAMIN C AS a RADIATION PROTECTIVE AGENT USING Γ-H2ax FOR SIGNALING OF DNA DAMAGE ON IRRADIATED MICE TESTIS

EVALUATION THE ROLE OF VITAMIN C AS a RADIATION PROTECTIVE AGENT USING Γ-H2ax FOR SIGNALING OF DNA DAMAGE ON IRRADIATED MICE TESTIS

Effects of antioxidant diet on the RBC indices in fructose-induced obesity rat model

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