RAFT-based synthesis and the gelation property of telechelic polymers that can immobilize biomacromolecules

Abstract

Telechelic polymers, macromolecules having two reactive end groups, can serve as building blocks for constructing polymers or polymeric materials that have complex architectures. Among the telechelic polymers, polymers bearing hydroxyl groups at two terminals have been used as components for preparation of functional materials. In the present study, RAFT polymerization of both N‐acryloylmorphorin and N‐succinimidyl acrylate by using a newly synthesized dithiobenzoate‐type chain transfer agent bearing hydroxyl groups at both terminals (HECPHD) was reported. After the acryloylation of the hydroxyl terminals of the obtained polymer, gelation was observed. Furthermore, the polymer could react with a protein via the conjugation of the succinimidyl esters‐containing polymers to the amino groups present on the protein surface. The results show that activated esters‐bearing polymers with hydroxyl groups at both terminals can be used as building blocks for constructing polymeric materials for an immobilization of biomacromolecules. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 1356–1365

Hydrogen bonding driven self‐assembly of side‐chain amino acid and fatty acid appended poly(methacrylate)s: Gelation and application in oil spill recovery

“…While LMWOG derived physical gel involves arrays of monomer units neatly linked through noncovalent bonds, supramolecular crosslinking in conventional polymers is generally achieved by incorporating a crosslinking agent in the polymer backbone, conformational change in the polymeric backbone or by selective phase separation of one block as in case of di‐ or tri‐block copolymers . Whereas, most vinyl polymers (apart from stereoregular polystyrenes and poly(methyl methacrylates)) fail to form organogel in organic solvents and oils due to lack of suitable “stickers” or “crosslinking junctions” in the polymer backbone .…”

RAFT-Based Polymers for Click Reactions

“…For example, Bohec et al [ 195 ] combined removing the trithiocarbonate end groups, achieved in alkyne-R-group-functionalized PNIPAM by the reaction with AIBN, with a thiol–yne click reaction. RAFT copolymerization of N-acryloylmorpholine and N-succinimidyl acrylate was carried out using a dithiobenzoate, bearing a hydroxyl substituent in leaving R group [ 196 ].…”