RAFT dispersion polymerization of glycidyl methacrylate for the synthesis of epoxy-functional block copolymer nanoparticles in mineral oil

Abstract

Epoxy-functional poly(stearyl methacrylate)-poly(glycidyl methacrylate) (PSMA-PGlyMA) diblock copolymer nanoparticles are synthesized via reversible addition–fragmentation chain transfer (RAFT) dispersion polymerization of glycidyl methacrylate (GlyMA) in mineral oil at 70 °C.

PhotoATRP-Induced Self-Assembly (PhotoATR-PISA) Enables Simplified Synthesis of Responsive Polymer Nanoparticles in One-Pot

“…[16][17][18] Using this method the solid content and degrees of polymerization can be modulated to tune NP morphologies. [19][20][21][22] Further, to improve NP stability for biomedical applications, different strategies, such as core crosslinking (CCL) and shell crosslinking (SCL) procedures, are utilized, mostly via post-polymerization methods adding additional complications to synthetic protocols. [23][24] The emergence of ATRP methods like Initiators for Continuous Activator Regeneration (ICAR) ATRP and Activators Regenerated by Electron Transfer (ARGET) ATRP allowed for reduction of required catalyst concentration (~1600 ppm) and enhanced oxygen tolerance compared to conventional ATRP.…”

Epoxy-functional diblock copolymer spheres, worms and vesicles via polymerization-induced self-assembly in mineral oil

“…The polymerization technique most commonly utilized for PISA syntheses is reversible addition-fragmentation chain transfer (RAFT) polymerization: [8][9][10] there are numerous literature examples of RAFT-mediated PISA formulations for polar solvents such as water [11][12][13][14][15][16][17] or ethanol. [18][19][20][21][22][23] Recently, RAFT dispersion polymerization formulations have also been devised for non-polar solvents such as n-heptane, 24,25 n-octane, 26,27 ndodecane, 28 iso-dodecane, 29,30 n-tetradecane, 27,31,32 mineral oil, [33][34][35][36][37] poly(α-olefins) 33 and silicone oils. 38,39 The three most common copolymer morphologies obtained via PISA are spheres, worms and vesicles.…”

Rapid production of block copolymer nano-objects via continuous-flow ultrafast RAFT dispersion polymerisation

“…[1][2][3][4][5] PISA is also highly versatile, since many different monomers can be polymerised in a wide range of solvents, directly resulting in block copolymer nanoparticles with tuneable size, morphology and functionality. [6][7][8][9] These materials have extremely attractive properties which have resulted in a broad range of applications including as cell storage or growth media, [10][11][12] viscosity modifiers, 13 friction reducing agents, 14,15 and as nano-reactors. 16 This rapid growth in applicability means cost effective scale-up of PISA synthesised polymers is desirable.…”