Raft forming system—An upcoming approach of gastroretentive drug delivery system

Prajapati, Vipul D.; Jani, Girish K.; Khutliwala, Tohra A.; Zala, Bhumi S.

doi:10.1016/j.jconrel.2013.02.028

Cited by 150 publications

(143 citation statements)

References 69 publications

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“…This type of system used for the treatment of gastroesophageal reflux treatment. This type of system has an advantage of producing layer over the upper section of gastric fluid (Prajapati et al, 2013;Tiwari et al, 2015).…”

Section: Figurementioning

confidence: 99%

Updates on Approaches to Increase the Residence Time of Drug in the Stomach for Site Specific Delivery: Brief Review

2018

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In the field of oral drug delivery system, a gastroretentive system is gaining popularity day by day. Numerous of research work and extensive literature are published in past few years on gastroretentive drug delivery system. It is the one of the best and appropriate approaches for increasing the residence time of drug in the stomach and diffuses drug slowly in the sustained manner which helps in the site-specific delivery of the drug as well also increases the bioavailability at site-specific of delivery. This helps in many challenges associated with conventional oral drug delivery system. Different ways are used for approaching gastroretention viz. swelling and expandable system, high-density system, magnetic system, bioadhesive system and buoyant system with or without gas generating agents. During data mining well in vitro characterization and in vivo characterization including gamma scintigraphic and MRI techniques are well established and reported. But, still, today in vivo characterization technique is major challenging for the researcher due to its limitation. The documented literature explains the use of animal models like beagle dogs, rabbits and human subjects for in vivo evaluation parameter but it leads to increase in variation that’s why this delivery system is limited in the market. This paper contains the latest literature compilation and various techniques used for gastroretention with its pros and cons. This review paper helps the researcher to take an overview of basics of gastroretentive drug delivery system and helps in understanding the basics of the system.Soni et al., International Current Pharmaceutical Journal, April 2018, 6(11): 81-91http://www.icpjonline.com/documents/Vol6Issue11/02.pdf

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Section: Figurementioning

confidence: 99%

Updates on Approaches to Increase the Residence Time of Drug in the Stomach for Site Specific Delivery: Brief Review

2018

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“…Gelation involves formation of the double helical junction zones followed by aggregation of the double helical segments which form three dimensional networks by complexation with cations and hydrogen bonding. [19] The raft floats because of the buoyancy created by the formation of CO2 and acts as a barrier to prevent the reflux of gastric contents like HCl and enzymes into the esophagus (see fig. 4.…”

Section: Raft Forming Systemsmentioning

confidence: 99%

Gastroretentive Drug Delivery Systems: From Conception to Commercial Success

Shah¹,

Prajapati²,

Patel³

2017

J Crit Rev

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Despite the extensive advancements in the field of drug delivery, the oral route remains the favorable route for administration of therapeutic actives. A success of oral controlled drug delivery systems is associated with reduced dosing frequency, decreased fluctuation in plasma drug concentration profile along with improved patient compliance. However, they are also associated with challenges like shorter gastric residence time, unpredictable gastric emptying and poor bioavailability for some molecules. This has initiated tremendous advancements in the field of gastro-retention to achieve controlled release of drugs along with improved bioavailability of drugs with narrow absorption window as well as localized action in the stomach and upper part of GIT. In present review, efforts have been envisaged to summarize our current understanding in the field of gastro-retention and their in vitro as well as in vivo characterization. Present review also highlights commercially utilized gastro-retentive technologies and some recently granted US patents in the field of GRDDS.

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“…In light of the physicochemical properties of curcumin, delivering curcumin as a Gastroretentive Drug Delivery System (GRDDS) would be an ideal approach to perk up the effectiveness of curcumin by prolonging its gastric residence so that the drug is released in the vicinity of its absorption window for an extended period of time and remains stable too [43][44][45][46][47]. Among the numerous approaches used to improve the gastric residence time of Drug Delivery System (DDS), the vital ones include, single and multiple-unit floating systems, bioadhesive systems, swelling unfoldable and expanding systems, raft forming systems and high-density systems [43][44][45][46].…”

Section: Developing Curcumin Loaded Gastroretentive Drug Delivery Sysmentioning

confidence: 99%

“…Among the numerous approaches used to improve the gastric residence time of Drug Delivery System (DDS), the vital ones include, single and multiple-unit floating systems, bioadhesive systems, swelling unfoldable and expanding systems, raft forming systems and high-density systems [43][44][45][46]. However, while selecting the ideal approach of gastric retention for curcumin, the solubility cum stability profile of curcumin should be kept in mind so as to have a stable delivery system with ideal dissolution characteristics.…”

Section: Developing Curcumin Loaded Gastroretentive Drug Delivery Sysmentioning

confidence: 99%

Pharmaceutical Developability of Clinically Relevant Flavonoids like Curcumin: Why are We Failing?

D¹,

Jayanthi²,

Joshi³

2017

Med Clin Rev

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Flavonoids are promising therapeutic class of polyphenolic biomolecules with the potential to alleviate many severe disease states with multi-factorial pathogenesis because of their inherent ability to regulate key biological cascades at the molecular, cellular and organism levels. However, these important polyphenolic compounds frequently pose drug delivery challenges to scientists and produce inefficient pharmacokineticpharmacodynamic activities. Importantly, despite their therapeutic potential and the focus of the scientists being on the formulation development front in the recent years, developing an ideal drug delivery system for some of the most important polyphenolic biomolecules such as curcumin is still a challenge. Hence, the basic intent of writing this article is to bring back the focus of the formulation scientists on one of the key physicochemical properties of these important biomolecules i.e., the importance of pH-stability profile of flavonoids, which could play vital role in the formulation developability aspects of important biomolecules such as curcumin by the selection of an ideal dosage form.

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Raft forming system—An upcoming approach of gastroretentive drug delivery system

Cited by 150 publications

References 69 publications

Updates on Approaches to Increase the Residence Time of Drug in the Stomach for Site Specific Delivery: Brief Review

Updates on Approaches to Increase the Residence Time of Drug in the Stomach for Site Specific Delivery: Brief Review

Gastroretentive Drug Delivery Systems: From Conception to Commercial Success

Pharmaceutical Developability of Clinically Relevant Flavonoids like Curcumin: Why are We Failing?

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