RAGE regulation and signaling in inflammation and beyond

Kierdorf, Katrin; Fritz, Günter

doi:10.1189/jlb.1012519

Cited by 361 publications

(320 citation statements)

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“…Several studies have demonstrated interactions of MRP8/MRP14 with RAGE, focusing mainly on signaling pathways involving activation of MAPK p38 or the transcription factor NF-kB, including cellular mechanisms downstream of the MRP8/MRP14-RAGE interaction. However, no structural data regarding the ligand-receptor recognition sites have been described so far (21,22,24,38). Similar MRP8/MRP14-RAGE interactions were observed in a study done by Boyd et al (23) on purified cardiomyocytes, during which RAGE was coimmunoprecipitated with MRP8/ MRP14.…”

Section: Discussionmentioning

confidence: 78%

Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8

Fassl¹,

Austermann²,

Papantonopoulou

et al. 2015

The Journal of Immunology

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The alarmins myeloid-related protein (MRP)8 and MRP14 are the most prevalent cytoplasmic proteins in phagocytes. When released from activated or necrotic phagocytes, extracellular MRP8/MRP14 promote inflammation in many diseases, including infections, allergies, autoimmune diseases, rheumatoid arthritis, and inflammatory bowel disease. The involvement of TLR4 and the multiligand receptor for advanced glycation end products as receptors during MRP8-mediated effects on inflammation remains controversial. By comparative bioinformatic analysis of genome-wide response patterns of human monocytes to MRP8, endotoxins, and various cytokines, we have developed a model in which TLR4 is the dominant receptor for MRP8-mediated phagocyte activation. The relevance of the TLR4 signaling pathway was experimentally validated using human and murine models of TLR4- and receptor for advanced glycation end products–dependent signaling. Furthermore, our systems biology approach has uncovered an antiapoptotic role for MRP8 in monocytes, which was corroborated by independent functional experiments. Our data confirm the primary importance of the TLR4/MRP8 axis in the activation of human monocytes, representing a novel and attractive target for modulation of the overwhelming innate immune response.

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Section: Discussionmentioning

confidence: 78%

Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8

Fassl¹,

Austermann²,

Papantonopoulou

et al. 2015

The Journal of Immunology

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“…Table I summarizes these RAGE ligands, including their chromosomal map locations, OMIM numbers, and a brief summary of each ligand. These can be found in greater detail in several references [Hudson et al, 2005;Kalea et al, 2009;Rojas et al, 2010;Yanai et al, 2009;Ramasamy et al, 2012;Kierdorf and Fritz, 2013]. Many RAGE ligands have various RAGE-independent effects as well [Logsdon et al, 2007;Sparvero et al, 2009].…”

Section: Rage Ligandsmentioning

confidence: 98%

“…AGE levels are lower in RAGE null mice, leading to the observation that glyoxalase 1 (Glo 1) a detoxifies methylglyoxal (MG). Thus, the action of RAGE not only contributes to the generation of AGE, but also to its perpetuation [Hudson et al, 2005;Kalea et al, 2009;Rojas et al, 2010;Ramasamy et al, 2012;Kierdorf and Fritz, 2013 Table II) [Sparvero et al, 2009;Rojas et al, 2010;Kierdorf and Fritz, 2013] …”

Section: The Role Of Rage In Cardiovascular Disease Based On Experimementioning

confidence: 99%

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Perspectives on RAGE signaling and its role in cardiovascular disease

Cohen

2013

American J of Med Genetics Pt A

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RAGE stands for Receptor of Advanced Glycation Endproducts. The two main topics discussed are (1) the nature of RAGE signaling and (2) its role in cardiovascular disease. RAGE may occur in membrane‐bound form or in secretory form. RAGE signaling involves multiple ligands: (1) several AGEs (2) amyloid β pecursor protein (APP), (3) high mobility group box 1 (HMGB1), (4) S100A4, (5) S100A8/A9, and (6) S100A12, which are calcium‐binding proteins, and (7) S100B, a glial‐derived protein. RAGE ligands and various diseases involving RAGE signaling are summarized in tabular form. © 2013 Wiley Periodicals, Inc.

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“…Interaction between full-length RAGE and AGEs causes enhanced expression of adhesion molecules, covering soluble vascular cell adhesion molecule-1 (sVCAM-1) together with cytokine tumor necrosis factor-alpha (TNF-α) [5] [6]. Conversely, activation of nuclear factor-kappa results in enhanced expression of pro-inflammatory genes [5] [7]; Circulating isoforms RAGE covering sRAGE is laminated from cell appearance via matrix metalloproteinases as well as endogenous secretory RAGE (esRAGE) [3] [4]. S100A12 refers to an inflammatory ligand of RAGE, which belongs to the S100 protein family.…”

Section: Introductionmentioning

confidence: 99%

Association of Serum Soluble Receptor for Advanced Glycation End Products (sRAGE), S100A12, and VCAM-1 Levels with Further Post-Coronary Angiogram Endothelial Injury in Elderly and Younger Patients

Mungun¹,

Zakaria²,

Wang³

et al. 2018

WJCD

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Objective: Coronary Angiography (CAG) refers to an aggressive process that is likely to lead to endothelial injury and possibly drive further interpretation of the cause for patients within current atherosclerotic illnesses. Therefore, this study aims to test certain correlations among concentration of sRAGE, VCAM-1, as well as S100A12 pre-and post-coronary angiography alongside likelihood of endothelial injury among various patients in different ages including the younger and the geriatric groups, thereby offering a full connection upon CAG impacts of patients having atherosclerosis. Method: In this study, the whole patients chosen had been grouped into two major groups on the basis of ages: the younger patient aged less than 65 years old (Group 1), and the elderly patient aged over 65 years old (Group 2). Soluble RAGE (sRAGE), VCAM-1 and S100A12 degrees in blood sampling gathered followed by measurements of CAG session for evaluating the inflammatory responses and likelihood of endothelial injury caused via CAG. All data was analyzed using SPSS version 21.0. Findings: Significant enhancement among concentration of serum VCAM-1 (P = 0.007) in younger patients and sRAGE (P = 0.019) in elderly patients had been observed, but that of serum S100A12 was still unaltered. Conclusions: Enhanced concentration of sRAGE and VCAM-1 post-CAG of patients having CAD are able to be related to follow-up endothelial injury, thus contributing to different pathway in exacerbating endothelial injury among younger and elderly patients.

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RAGE regulation and signaling in inflammation and beyond

Cited by 361 publications

References 174 publications

Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8

Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8

Perspectives on RAGE signaling and its role in cardiovascular disease

Association of Serum Soluble Receptor for Advanced Glycation End Products (sRAGE), S100A12, and VCAM-1 Levels with Further Post-Coronary Angiogram Endothelial Injury in Elderly and Younger Patients

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