Ragweed (Ambrosia) progression and its health risks: will Switzerland resist this invasion?

Taramarcaz, Philip; Lambelet, B; Clot, Bernard; Keimer, C.; Hauser, Claire T.

doi:10.4414/smw.2005.11201

Cited by 42 publications

(6 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite low genetic structure and high gene flow across much of its range (McGoey & Stinchcombe, 2021; van Boheemen et al, 2017), the species has locally adapted and evolved parallel latitudinal clines in size and phenology where high‐latitudinal populations flower early when small and low‐latitudinal populations flower later when tall (Chun et al, 2011; Hodgins & Rieseberg, 2011; Li et al, 2015; van Boheemen et al, 2019). Its wind‐spread pollen can travel several thousands of kilometers and can induce allergic rhinitis in human populations, costing millions of dollars in medical treatment each year (Taramarcaz et al, 2005).…”

Section: Methodsmentioning

confidence: 99%

Quantitative trait loci mapping reveals an oligogenic architecture of a rapidly adapting trait during the European invasion of common ragweed

Prapas

Scalone

Lee

et al. 2022

Evolutionary Applications

View full text Add to dashboard Cite

Biological invasions offer a unique opportunity to investigate evolution over contemporary timescales. Rapid adaptation to local climates during range expansion can be a major determinant of invasion success, yet fundamental questions remain about its genetic basis. This study sought to investigate the genetic basis of climate adaptation in invasive common ragweed ( Ambrosia artemisiifolia ). Flowering time adaptation is key to this annual species' invasion success, so much so that it has evolved repeated latitudinal clines in size and phenology across its native and introduced ranges despite high gene flow among populations. Here, we produced a high‐density linkage map (4493 SNPs) and paired this with phenotypic data from an F2 mapping population ( n = 336) to identify one major and two minor quantitative trait loci (QTL) underlying flowering time and height differentiation in this species. Within each QTL interval, several candidate flowering time genes were also identified. Notably, the major flowering time QTL detected in this study was found to overlap with a previously identified haploblock (putative inversion). Multiple genetic maps of this region identified evidence of suppressed recombination in specific genotypes, consistent with inversions. These discoveries support the expectation that a concentrated genetic architecture with fewer, larger, and more tightly linked alleles should underlie rapid local adaptation during invasion, particularly when divergently adapting populations experience high levels of gene flow.

show abstract

Section: Methodsmentioning

confidence: 99%

Quantitative trait loci mapping reveals an oligogenic architecture of a rapidly adapting trait during the European invasion of common ragweed

Prapas

Scalone

Lee

et al. 2022

Evolutionary Applications

View full text Add to dashboard Cite

show abstract

“…In 2005, 14% of the population near Milan already suffered from Ambrosia allergy [16]. Due to the wide spreading of Ambrosia in Italy [17,18], the sensitisation to this pollen has also attracted considerable attention in the southern part of Switzerland (Ticino), close to northern Italy (Lombardia) [19][20][21][22]. In fact, a large proportion of the Ambrosia pollen registered in the south of Switzerland in Ticino is considered to originate from Italy [23,24].…”

Section: Introductionmentioning

confidence: 99%

“…In fact, a large proportion of the Ambrosia pollen registered in the south of Switzerland in Ticino is considered to originate from Italy [23,24]. Whereas Geneva showed a significant increase in pollen load from 1979-2001, correlated to the increased pollen concentration in the Lyon region in France [21,25], for Ticino such an increase was not observed [23,24].…”

Section: Introductionmentioning

confidence: 99%

Time lag between Ambrosia sensitisation and Ambrosia allergy: A 20-year study (1989–2008) in Legnano, northern Italy

Tosi¹,

Wüthrich²,

Bonini³

et al. 2011

Swiss Med Wkly

View full text Add to dashboard Cite

show abstract

“…Ambrosia artemisiifolia is the most important from the allergic point of view, as its pollen is extremely allergenic and very low concentrations can trigger allergic reactions (allergic rhinitis, asthma or contact dermatitis) in sensitive patients. Allergy to pollen from Ambrosia artemisiifolia is a serious health issue exerting a strong negative impact on the quality of life of allergic patients [2,3].…”

Section: Introductionmentioning

confidence: 99%

Design of an Epitope-Based Peptide Vaccine Against the Major Allergen Amb a 11 Using Immunoinformatic Approaches

et al. 2022

View full text Add to dashboard Cite

Allergic diseases are a socially significant problem of global importance. The number of people suffering from pollen allergies has increased dramatically in recent decades. Pollen allergies affect up to 30% of the world population. Pollen of the common ragweed (Ambrosia artemisiifolia L.) is one of the most aggressive allergens in the world. We have used a series of immunoinformatics approaches to design an effective epitope-based vaccine, which might induce a competent immunity against a major allergen Amb a 11. CD8+ and CD4+ T-cell epitopes and their corresponding MHC restricted alleles were identified by prediction tools provided by immune epitope database (IEDB). Among T-cell epitopes, MHC class I peptide (GLMEPAFTYV) and MHC class II peptide (LVCFSFSLVLILGLV) were identified as most suitable. From all predicted B-cell epitopes, only one epitope (GKLVKFSEQQLVDC) containing sequence from the conserved region was chosen for next processing. Selected epitopes have been validated by molecular docking analysis. These epitopes showed a very strong binding affinity to MHC I molecule and MHC II molecule with binding energy scores − 729.3 and − 725.0 kcal/ mole respectively. Performed experimental validation showed that only the MHC class II peptide (LVCFSFSLVLILGLV) can stimulate T cells from ragweed allergic patients and IgE antibodies specific to the ragweed pollen do not recognize this epitope. Therefore, this peptide could be potentially used as a vaccine against the major allergen Amb a 11. The B-cell epitope GKLVKFSEQQLVDC forms a stable complex with the IgE molecule (energy weighted score − 695,0 kcal/mole). Tested sera from patients with ragweed allergy showed that the ragweed specific IgE antibodies can bind to the identified B-cell epitope. Population coverage analysis was performed for CD8+ and CD4+ T-cell epitopes. It was predicted that CD4+ T-cell epitope (LVCFSFSLVLILGLV) covers 90.56% of the population of Europe and 99.36% of the world population. CD8+ T-cell epitope (GLMEPAFTYV) has a population coverage of 77.37% for Europe and 71.35% for all the world.

show abstract

Ragweed (Ambrosia) progression and its health risks: will Switzerland resist this invasion?

Cited by 42 publications

References 51 publications

Quantitative trait loci mapping reveals an oligogenic architecture of a rapidly adapting trait during the European invasion of common ragweed

Quantitative trait loci mapping reveals an oligogenic architecture of a rapidly adapting trait during the European invasion of common ragweed

Time lag between Ambrosia sensitisation and Ambrosia allergy: A 20-year study (1989–2008) in Legnano, northern Italy

Design of an Epitope-Based Peptide Vaccine Against the Major Allergen Amb a 11 Using Immunoinformatic Approaches

Contact Info

Product

Resources

About