The movement of the liquid cargo within a partly filled tank car is known to impose additional slosh forces and moments that may adversely affect the dynamic responses of the vehicle. This study is aimed at analyzing the liquid cargo slosh in a partly filled tank car and its effects on vehicle responses during a switch-passing maneuver. A two-dimensional analytical liquid slosh model is formulated for the analyses of the liquid load shift in the roll plane, lateral slosh force, and roll moment through summation of first four antisymmetric modes of the liquid. The analytical slosh model is integrated to a 114 degrees-of-freedom multibody dynamic model of the railway tank car comprising nonlinear wheel–rail contact and contact pairs of the suspension system. The validity of the slosh model is illustrated by comparing the responses with those reported in other studies and those obtained from a nonlinear computational fluid dynamic model. The coupled fluid–vehicle model is subsequently used to study the effects of fluid slosh during switch-passing maneuvers on different response measures, namely roll motion of the tank car, lateral and vertical wheel–rail contact forces, and derailment ratio. The significance of the liquid cargo slosh in the partially filled state is demonstrated by comparing the responses with those of the car with equivalent rigid cargo. The results show that liquid sloshing within the partly filled car can lead to higher magnitudes of car body roll angle and thereby the unloading ratio compared to the conventional rigid cargo car. Switch-passing critical speeds are further identified for different fill ratios and switch geometries. For fill ratios below 80%, the switch-passing critical speeds of the partly filled car are substantially lower compared to those of the equivalent rigid cargo car. Neglecting the contributions due to dynamic slosh force and roll moment arising from a partially filled railway tank car may thus lead to underestimation of the critical speed in switch-passing maneuvers.