Rainbow trout Sox24, a novel member of the Sox family, is a transcriptional regulator during oogenesis

Kanda, Hiromi; Kojima, Miho; Miyamoto, Natsuki; Ito, Michihiko; Takamatsu, Nobuhiko; Yamashita, Shinya; Shiba, Tadayoshi

doi:10.1016/s0378-1119(98)00100-0

Cited by 28 publications

(11 citation statements)

References 31 publications

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“…In rainbow trout ovary, on the basis of the HMG box amino acid sequence, SOX24 can be categorized into the same subgroup of SOX proteins as SOX4, SOX11 and SOX22. These results suggest that SOX24 plays a role as a transcriptional regulator during oogenesis [35]. Our results regarding the change of mRNA in PV compared to VT and FOM as was found in blue gourami are in agreement with the result for SOX9 transcription in oogensis in catfish [34].…”

Section: Discussionsupporting

confidence: 91%

Expression of SOX3 and SOX9 Genes in Gonads of Blue Gourami

Degani¹

2014

ABC

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In vertebrates, SOX (SRY-related HMG box) genes are thought to be due to major gene duplication events, initially occurring during early stages of metazoan evolution and later during the transition between non-vertebrate chordates and vertebrates. The aim of this study is to examine SOX3 and SOX9 transcription in oogensis and spermatogenesis in a fish model, the blue gourami (Trichogaster trichopterus). In females during oogenesis, SOX9 mRNA levels were lower compared to SOX3 mRNA levels. In males, SOX9 mRNA levels were higher in testes compared to SOX3 mRNA levels, however no significant differences between SOX3 and SOX9 mRNA levels were observed in the gonads of males that were kept under non-reproductive conditions compared to males kept with females under reproductive conditions and that were nest-builders. Keywords SOX3, SOX9, mRNA and Blue Gourami

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Section: Discussionsupporting

confidence: 91%

Expression of SOX3 and SOX9 Genes in Gonads of Blue Gourami

Degani¹

2014

ABC

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“…1B). The zebrafish sox11a and sox11b sequences also group with Xenopus Sox13A and Sox13B (Hiraoka et al, 1997) and with rainbow trout sox24 (Kanda et al, 1998), suggesting that Xenopus Sox13A and Sox13B and rainbow trout sox24 represent sox11 orthologues. Indeed, Xenopus Sox13A (D83650) and Xenopus Sox11 (D86076) are 99% similar, suggesting that they are alleles of the same gene.…”

Section: Phylogenetic Analysis Of Zebrafish Sox11mentioning

confidence: 97%

Expression ofsox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development

et al. 2000

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“…Furthermore, the existence of acidic autoinhibitory regions has been reported in a wide range of transcription factors including RXR, Rfx1, E12, and Nkx6.1, although never before in a Sox protein (30 -33). The importance of the acidic region within Sox-11 is highlighted by the fact that long acidic stretches are also present within other Sox family members, such as Sox-22 and Sox-24 (39,40). Therefore, other Sox proteins may also contain binding autoinhibitory regions.…”

Section: Function Of Sox Proteins Is Highly Dependent On Theirmentioning

confidence: 99%

Identification of Novel Domains within Sox-2 and Sox-11 Involved in Autoinhibition of DNA Binding and Partnership Specificity

Wiebe

Nowling

Rizzino

2003

Journal of Biological Chemistry

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Sox transcription factors play key regulatory roles throughout development, binding DNA through a consensus (A/T)(A/T)CAA(A/T)G sequence. Although many different Sox proteins bind to this sequence, it has been observed that gene regulatory elements are commonly responsive to only a small subset of the entire family, implying that regulatory mechanisms exist to permit selective DNA binding and/or transactivation by Sox family members. To identify and explore the mechanisms modulating gene activation by Sox proteins further, we compared the function of Sox-2 and Sox-11. This led to the discovery that Sox proteins are regulated differentially at multiple levels, including transactivation, protein partnerships with Pit-Oct-Unc (POU) transcription factors, and DNA binding autoregulation. Specifically, we determined that Sox-11 activates transcription more strongly than Sox-2 and that the transactivation domain of Sox-11 is primarily responsible for this capability. Additionally, we demonstrate that the Sox-11 DNA binding domain is responsible for selective cooperation with the POU factor Brn-2. This requirement cannot be replaced by the DNA binding domain of Sox-2, indicating that the DNA binding domain of Sox proteins is critical for Sox-POU partnerships. Interestingly, we have also determined that a conserved domain of Sox-11 has the novel capability of autoinhibiting its ability to bind DNA in vitro and to activate gene expression in vivo. Our findings suggest that the autoinhibitory domain can repress promiscuous binding of Sox-11 to DNA and plays an important role in regulating the recruitment of Sox-11 to specific genes.

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Rainbow trout Sox24, a novel member of the Sox family, is a transcriptional regulator during oogenesis

Cited by 28 publications

References 31 publications

Expression of SOX3 and SOX9 Genes in Gonads of Blue Gourami

Expression of SOX3 and SOX9 Genes in Gonads of Blue Gourami

Expression ofsox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development

Identification of Novel Domains within Sox-2 and Sox-11 Involved in Autoinhibition of DNA Binding and Partnership Specificity

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