Combined impacts of sea-level rise, river flooding, increased frequency and magnitude of extreme rainfall, heatwaves, water scarcity, water pollution, ageing or lacking infrastructures for water, wastewater and solid waste in rapidly urbanising regions in the world call for improved water management and governance capacity in cities to accelerate the transition to water-wise cities. The sixteen contributions to this Special Issue create further awareness and present solutions on integrated approaches, advanced water management practices and water governance strategies. It is concluded that cities require a long-term strategy and a multilevel water governance approach. Research has shown how important it is to involve the civil society and private parties early on in this process to create success. Collaboration among cities and regions by sharing best practices for rapid implementation are crucial to cope with nearly all Sustainable Development Goals.