Raised Ca125 and ascites: Is this ovarian cancer till proven otherwise?

Birkett, Russell; Smith, Warren J.; Todd, Richard W.

doi:10.3109/01443615.2015.1094040

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…In the present study, preoperative ascites regression was independently associated with both improved cytoreduction and OS/PFS, suggesting ascites regression could confer benefits through mechanisms other than optimal cytoreduction. Whether the patient could achieve ascites regression or not could be influenced by many factors, such as histological type, chemotherapy response, tumor volume and sites and even invasion depth . The subgroup patients with higher optimal resection rate and chemotherapy response rate were more likely to show the disappearance of ascites, which could explain the relationship between ascites regression and prognosis to some extent.…”

Section: Discussionmentioning

confidence: 99%

“…Whether the patient could achieve ascites regression or not could be influenced by many factors, such as histological type, chemotherapy response, tumor volume and sites and even invasion depth. [32][33][34][35][36][37] The subgroup patients with higher optimal resection rate and chemotherapy response rate were more likely to show the disappearance of ascites, which could explain the relationship between ascites regression and prognosis to some extent. Currently, the guideline recommends four or less number of cycles of NAC for women with a response to NAC or with stable disease.…”

Section: Discussionmentioning

confidence: 99%

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Potential risk factors associated with prognosis of neoadjuvant chemotherapy followed by interval debulking surgery in stage IIIc–IV high‐grade serous ovarian carcinoma patients

Zhang

Liu

Zhang

et al. 2018

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Potential risk factors associated with prognosis of neoadjuvant chemotherapy followed by interval debulking surgery in stage IIIc–IV high‐grade serous ovarian carcinoma patients

Zhang

Liu

Zhang

et al. 2018

J of Obstet and Gynaecol

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“…Therefore, ascites regression should be regarded as a timing indicator for IDS. Ascites regression may be associated with histotype, chemotherapy response, tumor volume and sites, and even invasion depth [37–42]. The higher optimal resection rate and chemotherapy response rate accompany by the disappearance of ascites may explain the association between ascites regression and prognosis.…”

Section: Discussionmentioning

confidence: 99%

Ascites regression following neoadjuvant chemotherapy in prediction of treatment outcome among stage IIIc to IV high-grade serous ovarian cancer

Deng

et al. 2016

J Ovarian Res

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BackgroundNo consensus exists on the outcome-related factors of interval debulking surgery (IDS) in patients with advanced high-grade serous ovarian cancer (HG-SOC) who underwent neoadjuvant chemotherapy (NAC). This study aimed to explore the optimal timing for IDS and the prognosis-associated factors of International Federation of Gynecology and Obstetrics stage IIIc to IV HG-SOC patients.MethodsA total of 160 IIIc to IV stage HG-SOC patients were retrospectively analyzed. Patients with large volume ascites underwent NAC and subsequent IDS from the Jiangsu Institute of Cancer Research between 1993 and 2013. The outcome of IDS-associated factors was explored by logistic regression. To predict IDS outcome, the potential values of serum CA-125 levels and CA-125 decreasing kinetics were determined by the receiver operating characteristic curve. The associations between survival durations and covariates were assessed by Cox proportional hazards model and log-rank test.ResultsOptimal IDS was achieved in 80.6% of HG-SOC patients who underwent NAC. Multivariate analyses revealed that ascites regression (p = 0.01), serum CA-125 level (p = 0.02), and CA-125 decreasing kinetics (p = 0.01) were independent optimal IDS predictors. CA-125 decreasing kinetics, IDS outcome, and ascites volume were independently associated with overall survival (OS) (p = 0.04, p < 0.01, p = 0.03, respectively) and progression-free survival (PFS) (p < 0.01, p < 0.01, p = 0.02, respectively). Patients who exhibited disappearance of ascites (<500 ml) had longer PFS (19.7 months vs.14.9 months) and OS (32.1 months vs. 26.0 months) than patients who exhibited residual ascites (≥500 ml). Subsets with higher CA-125 decreasing kinetics (≥2.2) had longer PFS (21.4 months vs.13.1 months) and OS (29.6 months vs.26.8 months) than counterparts (kinetics < 2.2).ConclusionsAscites regression and CA-125 decreasing kinetics were independently associated with surgical outcome and prognosis in advanced HG-SOC patients who underwent NAC.

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Raised Ca125 and ascites: Is this ovarian cancer till proven otherwise?

Cited by 2 publications

References 5 publications

Potential risk factors associated with prognosis of neoadjuvant chemotherapy followed by interval debulking surgery in stage IIIc–IV high‐grade serous ovarian carcinoma patients

Potential risk factors associated with prognosis of neoadjuvant chemotherapy followed by interval debulking surgery in stage IIIc–IV high‐grade serous ovarian carcinoma patients

Ascites regression following neoadjuvant chemotherapy in prediction of treatment outcome among stage IIIc to IV high-grade serous ovarian cancer

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