Raised concentrations of plasma atrial natriuretic peptides in cardiac transplant recipients.

Singer, Donald R. J.; Buckley, M. G.; MacGregor, G. A.; Khaghani, Asghar; Banner, N.R.; Yacoub, Magdi H.

doi:10.1136/bmj.293.6559.1391

Cited by 50 publications

(9 citation statements)

References 3 publications

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“…Firstly, as found by previous workers [1,2], resting plasma ANF levels were elevated in cardiac allograft recipients despite normal graft function. Secondly, we have shown that cardiac allograft recipients have decreased renal function (lower ERPF and GFR) and that there was a significant inverse relationship between plasma ANF and these renal hemodynamic parameters.…”

Section: Discussionsupporting

confidence: 63%

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Raised plasma levels of atrial natriuretic factor in cardiac allograft recipients: evidence of increased cardiac secretion and decreased renal clearance

Lang

Moreland

Choy

et al. 1995

Eur J Clin Pharmacol

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The mechanism(s) causing high levels of plasma atrial natriuretic factor (ANF) in cardiac allograft recipients is(are) unclear. The kidney is important for the clearance of ANF and renal function may decline with cyclosporin A therapy in these patients. The relationship between plasma ANF level and renal function and also the pharmacokinetics of a continuous infusion of ANF (15.5 ng.kg-1.min-1 for 60 min) was examined in 6 cardiac allograft recipients on cyclosporin A therapy. Resting plasma ANF levels were significantly higher in these patients than in 8 healthy subjects (71 vs. 21 ng.l-1). Both effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) were significantly lower in these patients than in healthy subjects (215 vs. 617 ml.min-1 and 55 vs. 102 ml.min-1 respectively). There was a significant inverse correlation between plasma ANF and ERPF (r = -0.86) and between plasma ANF and GFR (r = -0.81). During the period of ANF infusion, steady state plasma ANF levels were significantly higher in cardiac allograft recipients. Total body clearance of ANF was marginally lower in these patients than in healthy subjects (60 vs. 10.0 l.min-1) although this difference did not reach statistical significance. Derived endogenous secretion rate of ANF was threefold higher in patients when compared to healthy subjects (633 vs. 208 ng.min-1). We have therefore shown that cardiac allograft recipients on cyclosporin A have elevated plasma ANF levels and also decreased renal function. Pharmacokinetic analysis have shown that this increase in plasma ANF levels is due more to increased ANF secretion than to decreased ANF clearance in these patients.

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Section: Discussionsupporting

confidence: 63%

“…High plasma levels of atrial natriuretic factor (ANF) have been reported in cardiac allograft recipients [1,2]. The mechanism(s) causing high levels of plasma ANF in these patients is (are) unclear and are probably multiple.…”

mentioning

confidence: 99%

Raised plasma levels of atrial natriuretic factor in cardiac allograft recipients: evidence of increased cardiac secretion and decreased renal clearance

Lang

Moreland

Choy

et al. 1995

Eur J Clin Pharmacol

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“…Levels of plasma ANP are markedly increased in heart transplant patients. [46][47][48] There are several factors underlying these higher levels of ANP, however, one explanation is that the increase is in part a marker of central volume expansion, confirmed by Braith's study showing that plasma volume is increased. 49 In one study, 50 mean 24-h plasma ANP was elevated by a mean of 44% in normotensive and 190% in hypertensive heart transplant recipients compared to healthy controls.…”

Section: Sodium Balance and Extracellular Fluid Volumementioning

confidence: 52%

Hypertension in thoracic transplant recipients

Jenkins

Singer

1998

J Hum Hypertens

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There are many mechanisms underlying the hypertension which occurs after thoracic transplantation. Previous disease, effects of cyclosporin, tacrolimus and steroid immunosuppression and cardiac denervation are major contributory factors. Abnormal sodium and water balance is an important common mediating factor. A new approach is clearly needed for classifying the severity of hypertension in these patients taking into account day-night variation and total blood pressure

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“…High plasma concentrations of ANP have been found in congestive heart failure, in certain congenital heart and pulmonary diseaes, during paroxysmal supraventricular tachycardia, and atrial pacing (6-10). Recently, higher plasma ANP concentrations were reported in eight patients following cardiac transplantation than in control patients (11). The effect of heart transplantation for end-stage cardiac failure on plasma ANP, which has not been reported earlier, was prospectively studied in this work.…”

mentioning

confidence: 86%

Plasma Atrial Natriuretic Peptide in Cardiac Transplant Recipients

Forslund

Fyhrquist

Tikkanen

et al. 1988

Journal of Internal Medicine

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Cardiac transplantation in 10 patients with congestive heart failure resulted in reduction of high plasma concentrations of atrial natriuretic peptide (ANP), preoperatively five‐fold above normal, to a level two‐fold above normal, which was maintained throughout a 12‐week follow‐up period. Cardiac function was normalized in all patients. Transient increases in plasma ANP, in four cardiac recipients 3–10‐fold their basal levels, could neither be related to rejection episodes nor to cardiac dysfunction, but rather to signs of fluid and sodium retention. High plasma ANP levels in cardiac transplant recipients suggest that the capacity to secrete ANP is preserved in the transplanted heart.

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Raised concentrations of plasma atrial natriuretic peptides in cardiac transplant recipients.

Cited by 50 publications

References 3 publications

Raised plasma levels of atrial natriuretic factor in cardiac allograft recipients: evidence of increased cardiac secretion and decreased renal clearance

Raised plasma levels of atrial natriuretic factor in cardiac allograft recipients: evidence of increased cardiac secretion and decreased renal clearance

Hypertension in thoracic transplant recipients

Plasma Atrial Natriuretic Peptide in Cardiac Transplant Recipients

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