Raised D-dimer among Admitted COVID-19 Patients in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Karki, None Dipesh; Gurung, Roshani; Nepali, Prasanna; Kaphle, Hari Prasad; Subedi, Bhabuk; Adhikari, Sundar

doi:10.31729/jnma.7579

Cited by 2 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The screening of effective biomarkers, patient classification, clinical management, and prevention of serious complications are essential in combating the progression of COVID-19, reducing severe and fatal outcomes, and improving treatment strategies [11]. Prominent biomarkers such as D-dimer, Serum ferritin, C-reactive protein (CRP), Interleukin-6, Lactate dehydrogenase (LDH), and HRCT have been identified for this purpose.…”

Section: Discussionmentioning

confidence: 99%

HRCT severity score as a predictive biomarker in severity assessment of COVID-19 patients

Karki,

Adhikari

2024

J Surg Med

Self Cite

View full text Add to dashboard Cite

Background/Aim: In 2020, the World Health Organization declared the Coronavirus disease of 2019 (COVID-19) a pandemic due to its widespread nature. The severity of COVID-19 infections leading to patient deaths is influenced by various factors. Therefore, it is crucial to identify and address these contributing causes for effective treatment of COVID-19. Methods: This study was conducted between 23 January 2021 and 19 June 2021 at a hospital with 100 beds in Western Nepal. Patient demographic data and High-resolution computed tomography severity scores were recorded. Microsoft Excel and Statistical Package for the Social Sciences were used for statistical data analysis. Binomial regression and Chi-square tests were applied, setting the significance level at P<0.05 with a confidence interval of 95%. Results: The study found a significant association between computed tomography (CT) severity, gender, and age with the treatment outcome among COVID-19-infected patients admitted to the hospital. Patients with a CT severity score between 16 and 25 had an eightfold higher mortality rate (OR: -8.802; 95% CI: 3.506–18.491). Conclusion: The severity and mortality of COVID-19 infections are influenced by factors such as age, gender, and biomarkers indicated by CT severity scores. Identifying additional factors that worsen COVID-19 patient’s conditions and increase the risk of mortality is essential.

show abstract

Section: Discussionmentioning

confidence: 99%

HRCT severity score as a predictive biomarker in severity assessment of COVID-19 patients

Karki,

Adhikari

2024

J Surg Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…From this study, we observed quantitative variation of phytoconstituents (ascorbic acid, total phenol, and flavonoid content) in citrus species grown in different regions of Western Nepal. Phytoconstituents, like ascorbic acid flavonoids, phenols, alkaloids, etc., are being used in allopathic and also found to be used traditionally as ethnomedicines for antiviral properties like in COVID-19 treatment [19][20][21]. The extraction of the juice of citrus fruit was done using ethanol as a solvent, and the extractive value was found to be higher in citrus species collected from Nawalparasi.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study on Ascorbic Acid Concentration, Total Phenol, and Flavonoid Content in Citrus Species Grown in a Different Region of Western Nepal

Gurung

Baral

Parajuli

et al. 2022

International Journal of Food Science

Self Cite

View full text Add to dashboard Cite

Different genetic and environmental factors like altitude, temperature, light radiation, etc. affect the production of phytoconstituents like ascorbic acid, phenol, flavonoid, tannin, etc. So, it is necessary to evaluate phytoconstituents quantitatively and qualitatively because of their different medicinal values. This study is aimed at evaluating and comparing ascorbic acid concentration, total phenol, and flavonoid content in citrus species grown in different places in Western Nepal. For this, fruit collected from Lamjung and Nawalparasi was peeled, and collected juice was extracted with ethanol. Ascorbic acid was estimated using titration with dichlorophenolindophenol dye, and total phenol was estimated using Folin reagent; whereas, flavonoid content was determined by aluminum chloride colorimetric assay. The result showed the maximum ascorbic acid concentration in the fruit juice of Citrus maxima collected from Lamjung, i.e., 2.98 ± 0.161 mg / 100 ml , and the least concentration was recorded on extract of Citrus limon collected from Nawalparasi, i.e., 1.005 ± 0.205 mg / 100 ml . The total phenol content was comparatively higher in Citrus maxima and Citrus aurantifolia collected from Lamjung, i.e., 12.48 ± 0.40 mg GAE/gm, respectively. Flavonoid content was comparatively higher in Citrus maxima collected from Nawalparasi, i.e., 484.466 ± 3.055 mg QE/gm. This study showed a variation in the concentration of chemical constituents between different places in Western Nepal. This might be due to differences in climatic conditions, environmental factors, altitude, temperature, etc. This study helps to reflect the best-suited altitude for commercial cultivation of the citrus species as these phytochemicals have different medicinal values. Also, this study can help the food industry to use an alternative source of synthetic antioxidant such as ascorbic acid, phenol, and flavonoid. And local people will economically benefit by the commercial cultivation of citrus fruits.

show abstract

Raised D-dimer among Admitted COVID-19 Patients in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Cited by 2 publications

References 12 publications

HRCT severity score as a predictive biomarker in severity assessment of COVID-19 patients

HRCT severity score as a predictive biomarker in severity assessment of COVID-19 patients

A Comparative Study on Ascorbic Acid Concentration, Total Phenol, and Flavonoid Content in Citrus Species Grown in a Different Region of Western Nepal

Contact Info

Product

Resources

About