Raised Plasma-Myoinositol Levels in Uræmia and Experimental Neuropathy

Clements, RexS.; DeJesus, Pacifico V.; Winegrad, AlbertI.

doi:10.1016/s0140-6736(73)91143-4

Cited by 98 publications

(40 citation statements)

References 16 publications

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“…sociated with that syndrome (21,32). In those studies we observed that the plasma free MI in normal rats can be chronically elevated to levels similar to those observed in chronic human uremics (approximately 0.50 mM) by feeding diets containing 35% free MI or by the repeated i.p.…”

Section: Introductionmentioning

confidence: 57%

Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes.

Greene¹,

Jesus²,

Winegrad³

1975

J. Clin. Invest.

485

259

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A B S T R A C T The factors influencing the development of impaired sciatic motor nerve conduction velocity (MNCV) in acute experimental diabetes were examined. Decreased MNCV developed by the 14th day after streptozotocin administration but only in rats which became hyperglycemic. Insulin treatment, begun on day 3, failed to prevent impaired MNCV in diabetic rats in which improved or normal weight gain and a decreased degree of hyperglycemia was induced. However, insulin treatment prevented the development of impaired MNCV in a group of diabetic rats in which the tail vein plasma glucose concentration was never found to exceed 160 mg/dl during days 6 through 14, and in which the mean+SEM of the average plasma glucose concentration for each animal during the same period was 754+18 mg/dl. In normal rats fed diets containing 0.011% or 0.069% free myoinositol (a presumably normal range), sciatic nerve free myoinositol concentrations were 90-and 60-fold higher than those in plasma. On

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Section: Introductionmentioning

confidence: 57%

Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes.

Greene¹,

Jesus²,

Winegrad³

1975

J. Clin. Invest.

485

259

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“…In humans, uremic polyneuropathy is associated with elevated plasma myo-inositol. When this condition was mimicked in rats, a reduction in sciatic motor-nerve conduction velocity was observed (4).…”

Section: Discussionmentioning

confidence: 99%

Polyol profiles in Down syndrome. myo-Inositol, specifically, is elevated in the cerebrospinal fluid.

Shetty¹,

Schapiro²,

Holloway³

et al. 1995

J. Clin. Invest.

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Polyols are reduction products of aldoses and ketoses; their concentrations in tissues can reflect carbohydrate metabolism. Several polyol species were quantitated in cerebrospinal fluid (CSF) and plasma from 10 Down Syndrome (trisomy 21) subjects between the ages of 22 and 63 years (3 of whom were demented) and from 10 healthy age-matched controls, using a gas chromatographic/mass spectrometric technique. The mean CSF concentration and the mean CSF/ plasma concentration ratio of myo-inositol were significantly elevated in Down syndrome compared with controls, but were not correlated with the presence of dementia in the Down subjects. Plasma myo-inositol was not significantly altered in these subjects. No significant difference between Down syndrome and controls was found for CSF concentrations of mannitol, sorbitol, galactitol, ribitol, arabitol, or 1,5-anhydrosorbitol, but plasma mannitol, ribitol and arabitol were elevated in Down syndrome. The present observation provides new impetus for studying synthesis and transport of myo-inositol as well as phosphatidylinositol cycle in trisomy 21 disorder. (J. Clin. Invest. 1995. 95:542-546.)

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“…[3], that myoinositol is retained in the plasma of patients with renal failure. Our myoinositol concentrations in normals are moderately higher than theirs (0.75 versus 0.43 mg/100 ml): but even with this difference in mind it can be said that the plasma con centrations in patients with renal insufficiency are in the same range for the two studies.…”

Section: Discussionmentioning

confidence: 99%

“…One of the substances discusse in this respect is myoinositol, a water-solub cyclic hexitol which is a constituent of a cla of phospholipids, the phosphatidyl inositol present in neural tissue. Pitkânen [2] ar Clements et al [3] have shown that myoinosit accumulates in the plasma of patients wii chronic renal failure. Moreover, the latt authors were able to demonstrate in rats th acute induction of hypermyoinositolemia w followed by a striking decrease in sciatic mot…”

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confidence: 99%

Myoinositol – a Uremic Neurotoxin?

Blumberg¹,

Esslen²,

Bürgi³

1978

Nephron

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In 28 patients predialysis plasma myoinositol was significantly elevated to 10.8 ± 2.: versus 0.75 ± 0.15 mg/100 ml in normals (mean ± 1 SD), and was weakly correlated with plasm; creatinine concentrations (r = 0.42, p < 0.05). Dialysis decreased plasma myoinositol con centrations to 3.5 ± 1.1 mg/100 ml. In 16 patients studied more extensively plasma myoinosito was similarly elevated to 10.6 ± 3.4 mg/100 ml, and spinal fluid myoinositol was increased t < 9.4 ± 2.3 mg/100 ml (versus 2.7 ± 0.7 in normals, p < 0.001). Nerve conduction velocities wer reduced in 15 and EEG tracings were abnormal in 12 of the 16 patients. However, neither spins fluid nor plasma myoinositol showed any correlation with nerve conduction velocities or EEG changes (r = 0.05–0.20, NS) Myoinositol is one of the substances retained in renal insufficiency but no indication was found that it is a toxin causing uremic neurological disturbances.

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Raised Plasma-Myoinositol Levels in Uræmia and Experimental Neuropathy

Cited by 98 publications

References 16 publications

Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes.

Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes.

Polyol profiles in Down syndrome. myo-Inositol, specifically, is elevated in the cerebrospinal fluid.

Myoinositol – a Uremic Neurotoxin?

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