Raised serum homocysteine levels in patients of coronary artery disease and the effect of vitamin B12 and folate on its concentration

Abstract

Homocysteine(Hcy) has been implicated as a novel risk factor of Coronary Artery Disease (CAD) among Asian Indians, but many studies done in India failed to reveal any direct correlation. It has also been reported that Folic acid and Vitamin B12 levels inversely affect serum levels of homocysteine. In this study, we looked at the levels of homocysteine among patients with CAD. The effect of Vitamin B12, Folate and other risk factors on homocysteine levels were also evaluated. Mean homocysteine levels in cases (22.81±13.9, n=70) were significantly higher (p=<0.001) than the controls (7.77±7.3, n=70). However no statistically significant correlation could be deduced between homocysteine Vitamin B12, and Folate. Cumulative analysis have indicated an increase in homocysteine levels among patients with CAD with every additional risk factor.

Clinical Correlation between Plasma Homocysteine Level and Coronary Artery Disease in Indian Patients

“…Homocysteine has been projected as a novel risk factor for CAD [13]. Some researchers embarked upon the mission to show plasma homocysteine as an independent risk factor for CAD.…”

Correlation of Serum Homocysteine Levels with the Severity of Coronary Artery Disease

“…However, despite aggressive control of risk factors in the general population, it is not possible to prevent progression of CAD in all patients. Homocysteine has been recognized as early in 1990s as a risk factor for the presence of atherosclerotic vascular disease and hypercoagulability states [7,8].…”

Screening the Effect of Metformin on Serum Vitamin B12 and Blood Homocysteine Levels in Patients with Type 2 Diabetes Mellitus

“…With regard to HC, as an important risk factor in vascular diseases in patients with diabetes, its levels were significantly higher in diabetic patients with cardiovascular diseases (CVD) than in normal subjects [29,30]. We found significant correlation between homocysteine levels and macrovascular complications (e.g.…”