Raised serum protein-bound iodine after topical clioquinol

Upjohn, A. C.; Galbraith, H.; Solomons, B

doi:10.1136/pgmj.47.549.515

Postgraduate Medical Journal

1971

DOI: 10.1136/pgmj.47.549.515

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Raised serum protein-bound iodine after topical clioquinol

A. C. Upjohn¹,

H. Galbraith

B Solomons³

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1978

1984

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Cited by 2 publications

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“…No studies have been made on the skin absorp tion of these substances. However, some absorp tion has been shown indirectly as a rise in serum protein-bound iodine following to pical application of clioquinol ( 18) or as a positive urine ferri chloride test falsely indicating phenylketonuria. (14).…”

mentioning

confidence: 99%

Absorption of 8-hydroxyquinolines through the human skin

Fischer¹,

Fagerlund²,

Hartvig³

1978

Acta Derm Venereol

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The skin absorption of clioquinol and chloroquinaldol in ointment or cream base was studied in fourteen patients with widespread dermatoses. A serum concentration in the range of 0.3--1.3 microgram/ml using clioquinol and 0.05--0.1 microgram/ml with chloroquinaldol was reached by the second day and persisted throughout the topical treatment. The mean serum half-life of clioquinol and of chloroquinaldol was estimated to 25 and 6 hours, respectively. Local application of zinc oxide ointment after the end of the treatment chelate-bound the skin deposits of clioquinol and lowered the serum half-life to 11 hours. The mean daily urinary excretion of the applied amount of clioquinol and chloroquinaldol was 4.5 and 6%, respectively.

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mentioning

confidence: 99%

Absorption of 8-hydroxyquinolines through the human skin

Fischer¹,

Fagerlund²,

Hartvig³

1978

Acta Derm Venereol

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Percutaneous Absorption of Iodochlorhydroxyquin in Humans

Stohs

Ezzedeen

Anderson

et al. 1984

Journal of Investigative Dermatology

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Iodochlorhydroxyquin (I) is used in the treatment of diaper rash and other skin disorders, and is presumed to undergo little or no percutaneous absorption. The absorption of (I) from a 3% cream was studied in 5 normal male subjects after a single application of the cream for 12 h. Plasma levels of the drug were followed for 24 h after initial application while urinary excretion was measured for 54 h. (I) was extracted from plasma and urine and assayed by high-performance liquid chromatography. The drug in the range of 0.37-0.56 micrograms/ml was detected in plasma 2 h after application and persisted throughout the treatment period. The mean excretion rate after 12 h of application was 58.4 micrograms/h and the excretion rate was 8.8 micrograms/h at 42 h posttreatment. The elimination rate constant was calculated to be 0.15 h-1. Approximately 40% of the drug was absorbed over the 12-h application period. From the above results it is apparent that significant percutaneous absorption of (I) occurs.

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Raised serum protein-bound iodine after topical clioquinol

Cited by 2 publications

References 10 publications

Absorption of 8-hydroxyquinolines through the human skin

Absorption of 8-hydroxyquinolines through the human skin

Percutaneous Absorption of Iodochlorhydroxyquin in Humans

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