Raising intestinal contents viscosity leads to greater excretion of neutral steroids but not bile acids in hamsters and rats

Carr, Timothy P.; Wood, Kimberly J.; Hassel, Craig A; Bahl, Rajan; Gallaher, Daniel D.

doi:10.1016/s0271-5317(02)00476-1

Cited by 27 publications

(20 citation statements)

References 35 publications

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“…Moreover, with a larger particle size of SDF powder, networks were easier to be formed which resulted in more particle interactions and thus higher apparent viscosity and yield stress (Mueller et al, 2009). According to the findings that the increase of viscosity of intestinal digested material could decrease cholesterol level (Carr et al, 2003), the grapefruit SDF would be more efficient on attenuating cholesterol concentration than others. Fig.…”

Section: Rheological Propertymentioning

confidence: 99%

Physicochemical characterization of five types of citrus dietary fibers

Wang

Yuan

et al. 2015

Biocatalysis and Agricultural Biotechnology

106

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Section: Rheological Propertymentioning

confidence: 99%

Physicochemical characterization of five types of citrus dietary fibers

Wang

Yuan

et al. 2015

Biocatalysis and Agricultural Biotechnology

106

View full text Add to dashboard Cite

“…The lower plasma cholesterol levels have been attributed to reduced cholesterol absorption based on the observation of increased bile acids or neutral sterol excretion in animals models, such as the hamster and rat. 41,42 However, the detailed mechanisms underlying the regulation of lipid metabolism and other related physiological responses remain unclear. In order to better understand the hypocholesterolemic and antidiabetic effect of HPMC, the adipocytokines involved in the regulation of lipid and glucose metabolism and their correlation with both circulating and hepatic lipid levels, as well as parameters of insulin sensitivity, were investigated in the present study.…”

Section: Effect Of Hpmc On Lipid and Glucose Metabolismmentioning

confidence: 99%

Dietary fiber improves lipid homeostasis and modulates adipocytokines in hamsters

Hung

Bartley

Young

et al. 2009

Journal of Diabetes

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IntroductionExcess energy storage in the form of triglycerides and the release of fatty acids have long been viewed as major functions of adipose tissue in total lipid and energy homeostasis. However, adipose tissue is also the site of the modulation of active metabolism and energy regulation. Fat accumulation in visceral adipose tissue is correlated with the occurrence of diabetes mellitus, hyperlipidemia, hypertension, and atherosclerotic diseases, and is associated with changes in the endocrine and metabolic functions of adipose tissue. Abstract Background: The hypocholesterolemic and hypoglycemic effects of various natural and semisynthetic dietary fibers have been studied for their potential use in the prevention and improvement of metabolic syndrome. Of these dietary fibers, hydroxypropyl methylcellulose (HPMC) has been shown to lower plasma cholesterol and reduce weight gain. However, the underlying mechanisms are not known. In the present study, we examined associations between plasma adipocytokine levels and both lipid metabolism and insulin sensitivity after HPMC intake in golden Syrian hamsters. In addition, endogenous adiponectin from hamster plasma was purified and characterized. Methods: Hamsters were treated with HPMC (2% and 4% in a high-fat diet) or 2% or 4% microcrystalline cellulose (MCC; control diet) for 8 weeks. Plasma glucose, insulin, lipids, adiponectin, leptin, and hepatic lipid levels were assessed using standard techniques. Results: After 8 weeks of feeding, plasma total cholesterol and triglyceride levels in hamsters fed the 4% HPMC-supplemented diet were significantly lower than in hamsters fed the control diet. Moreover, a significant increase in adiponectin levels and a decrease in leptin levels were observed in hamsters fed the 4% HPMC-supplemented diet. Hamster adiponectin was found to be comprised of 244 amino acid residues with an apparent molecular weight of 30 kDa, consistent with the adiponectin reported in other species. Conclusions: Reductions in plasma cholesterol and triglyceride levels were correlated with a decrease in plasma leptin and an increase in adiponectin. These results suggest that adipocytokines are regulated by HPMC and may play a pivotal role in the hypocholesterolemic effect.

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“…Scientific evidence for lipid lowering effect of dietary fibers has been accumulating in humans as well as animals (26,27). It has been well known that the possible mechanism is inhibition of lipid absorption by an enhanced neutral steroid excretion and increase of bile acid excretion (28). Dietary fibers also are believed to reduce appetite, energy intake and body weight (29).…”

Section: Resultsmentioning

confidence: 99%

Anti-obesity and hypolipidemic effects of chufa (Cyperus esculentus L.) in mice fed a high-fat diet

Moon

Ahn

Lee

et al. 2012

Food Sci Biotechnol

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This study was aimed to clarify the effect of defatted chufa (Cyperus esculentus L., DC) on dietinduced obesity and lipid metabolism in mice. C57BL/6J mice were fed 1 of 4 experimental diets for 7 weeks: a normal diet (N), a high-fat diet (HF), a high-fat diet with 5% DC (LDC), and a high-fat diet with 10% DC (HDC). DC supplementation (10%) significantly reduced body weight gain, adipose tissue weight, and adipocyte size increased by high-fat diet although there was no significant difference between HF group and LDC group. Serum total cholesterol and triglyceride levels of the HDC group were significantly decreased compared to those of the HF group. The hepatic triglyceride levels also decreased significantly with 10% DC supplementation, but not changed with 5% DC supplementation. Serum insulin and leptin levels in the LDC and HDC groups were significantly decreased compared to those of the HF group. These results suggest that defatted chufa may be useful for the prevention of dietinduced obesity and hyperlipidemia.

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Raising intestinal contents viscosity leads to greater excretion of neutral steroids but not bile acids in hamsters and rats

Cited by 27 publications

References 35 publications

Physicochemical characterization of five types of citrus dietary fibers

Physicochemical characterization of five types of citrus dietary fibers

Dietary fiber improves lipid homeostasis and modulates adipocytokines in hamsters

Anti-obesity and hypolipidemic effects of chufa (Cyperus esculentus L.) in mice fed a high-fat diet

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