Suburbanization, as a set of several factors, influences and changes the landscape structure of smaller municipalities in the hinterland of larger cities. The purpose of this paper is to evaluate the built-up areas related to suburbanization within three time horizons—in 2002, 2005, and 2020—in 62 municipalities of the district (including two cities, Nitra and Vráble). This study examines the process of spatial changes in landscape features (residential, industrial, agricultural, transport) related to suburbanization between 2002 and 2005 and between 2002 and 2020. The input analytical data were digital orthophotomaps from 2002 and 2005 and the current orthophotomosaics of the Slovak Republic from 2017 (GKÚ, Bratislava), updated for the year 2020 using Sentinel 2 satellite image data (European Space Agency). The impact of suburbanization processes between 2002 and 2005 did not reach the dimensions of the changes that occurred due to suburbanization processes between 2002 and 2020 or 2005 and 2020. The main research objective of the article is the identification and assessment of these changes. We determined which landscape features related to suburbanization affected spatial changes in municipalities of the district Nitra. The total area affected by one of the suburbanization processes monitored by us reached 92.52 ha in the period between 2002 and 2005. Between the years 2002 and 2020, the area reached a total of 2272.82 ha, which is an increase of 2180.30 ha in 2020 compared to 2002. This included mainly the expansion of settlements or housing (60.15%), industrial areas (29.31%), transport facilities (4.35%), agricultural areas (0.73%), and other areas (5.46%). These results show expanding suburbanization for the period from 2002 to 2020 and that this process has been gaining momentum in the municipalities of the Nitra district, especially in recent years, which changes the look of rural municipalities and the character of a typical rural landscape.