Raloxifene but not alendronate can compensate the impaired osseointegration in osteoporotic rats

Faverani, Leonardo Pérez; Polo, Tárik Ocon Braga; Ramalho-Ferreira, Gabriel; Momesso, Gustavo Antônio Corrêa; Hassumi, Jaqueline Suemi; Rossi, Ana Cláudia; Freire, Alexandre Rodrigues; Prado, Felippe Bevilacqua; Luvizuto, Eloá Rodrigues; Gruber, Reinhard; Okamoto, Roberta

doi:10.1007/s00784-017-2106-2

Cited by 34 publications

(39 citation statements)

References 27 publications

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“…In a few studies, implants were placed 56 days, 60 days, 84 days and 168 days before osteoporosis induction, while in 2 studies, they were placed at the time of osteoporosis induction. Only in 1 study, the time of implant placement was not clearly defined . The implants were inserted mainly into the rat tibia (65.85%) or in the femur (19.5%).…”

Section: Resultsmentioning

confidence: 99%

“…Only in 1 study, the time of implant placement was not clearly defined. 32 The implants were inserted mainly into the rat tibia (65.85%) or in the femur (19.5%). In 1 study, implants were placed into the medullary canal of the femur, 33 in 3 studies, they were placed into healed post-extraction sockets 29,34,35 and in 1 into the maxillary arch.…”

Section: Animal Modelsmentioning

confidence: 99%

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Osseointegration in osteoporotic‐like condition: A systematic review of preclinical studies

Dereka

Calciolari

Donos

et al. 2018

J of Periodontal Research

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Osteoporosis is one of the most common skeletal disorders affecting a significant percentage of people worldwide. Research data suggested that systemic diseases such as osteoporosis could act as risk factors for osseointegration, jeopardizing the healing process and thus the predictability of dental implant success on compromised patients. It is well accepted that preclinical studies in animal models reproducing the osteoporotic condition are one of the most important stages in the research of new biomaterials and therapeutic modalities. The aim of this systematic review was to investigate whether osteoporosis compromises dental implant osseointegration in experimental osteoporotic-like conditions. A 3-stage systematic literature research was conducted in MEDLINE via OVID and EMBASE up to and including March 2017. Experimental studies reporting on dental implant osseointegration on different osteoporotic animal models were assessed. The studies had to report on the percentage of bone-to-implant contact (%BIC) as the primary outcome. ARRIVE guidelines for reporting on animal research were applied to evaluate the methodological quality and risk of bias of the studies. Fifty-seven studies met the inclusion criteria and were assessed qualitatively. The most adopted animal model was the rat. A variability of %BIC values was observed, ranging from 30% to 99% and from 26% to 94% for the healthy and osteoporotic group, respectively. The great majority (47) of the included studies concluded that estrogen deficiency significantly affects BIC values, 9 studies stated that it was not possible to observe statistical differences in BIC between ovariectomized and healthy groups and 1 study did not provide a comparison between the healthy and osteoporotic group. Owing to the great heterogeneity in implant surface, study design, observation time-points, site of implant placement and reported outcomes, a meta-analysis could not be performed. An overall high risk of bias was observed, owing to the limited information on animal housing and husbandry, baseline characteristics and health status, ethical statement and allocation to the experimental groups provided. Although the available studies seem to suggest a lower osseointegration in osteoporotic-like conditions, no robust conclusions can be drawn due to the great heterogeneity and overall low quality of the available studies. Future studies with emphasis on minimizing the possible sources of bias and evaluating osseointegration of dental implants placed into jawbones instead of long bones are warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Animal Modelsmentioning

confidence: 99%

Osseointegration in osteoporotic‐like condition: A systematic review of preclinical studies

Dereka

Calciolari

Donos

et al. 2018

J of Periodontal Research

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“…The study of implant bioactivity in low-quality bone tissue, as performed in this research, is not related to the treatment of osteoporosis through medications that reverse this condition, such as anti-resorptive and selective estrogen receptor modulators (SERMs). Previous studies have shown that systemic treatment assisted in the molecular responses of bone tissue biology [36,44]. Thus, even in very critical bone metabolism situations, such as the OVX group, the PEO coating demonstrated reparative characteristics favorable to osseointegration.…”

Section: Discussionmentioning

confidence: 96%

“…The remaining 8 animals from each group were euthanized by anesthetic overdose (150 mg/kg sodium thiopental with 2% lidocaine, administered intraperitoneally) at 60 days after implantation for bone architecture characterization (computed microtomography, confocal microscopy, and histometry) [36,37].…”

Section: Analysis Of Peri-implant Bone Repairmentioning

confidence: 99%

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Comparison between Plasma Electrolytic Oxidation Coating and Sandblasted Acid-Etched Surface Treatment: Histometric, Tomographic, and Expression Levels of Osteoclastogenic Factors in Osteoporotic Rats

Momesso

Santos

et al. 2020

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Plasma electrolytic oxidation (PEO) has been a promising surface coating with better mechanical and antimicrobial parameters comparing to conventional treatment surfaces. This study evaluated the peri-implant bone repair using (PEO) surface coatings compared with sandblasted acid (SLA) treatment. For this purpose, 44 Wistar rats were ovariectomized (OVX-22 animals) or underwent simulated surgery (SS-22 animals) and received implants in the tibia with each of the surface coatings. The peri-implant bone subsequently underwent molecular, microstructural, bone turnover, and histometric analysis. Real-time PCR showed a higher expression of osteoprotegerin (OPG), receptor activator of nuclear kappa-B ligand (RANKL), and osteocalcin (OC) proteins in the SLA/OVX and PEO/SS groups (p < 0.05). Computed microtomography, confocal microscopy, and histometry showed similarity between the PEO and SLA surfaces, with a trend toward the superiority of PEO in OVX animals. Thus, PEO surfaces were shown to be promising for enhancing peri-implant bone repair in ovariectomized rats.

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Targeted Drug Delivery from Titanium Implants: A Review of Challenges and Approaches

Barik¹,

Chakravorty²

2019

Advances in Experimental Medicine and Biology

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Raloxifene but not alendronate can compensate the impaired osseointegration in osteoporotic rats

Abstract: Regarding the superiority of raloxifene observed in the improvement of bone dynamics response, this statement suggests that raloxifene could be a good option for osteoporosis patients in oral rehabilitation procedures.

Cited by 34 publications

References 27 publications

Osseointegration in osteoporotic‐like condition: A systematic review of preclinical studies

Osseointegration in osteoporotic‐like condition: A systematic review of preclinical studies

Comparison between Plasma Electrolytic Oxidation Coating and Sandblasted Acid-Etched Surface Treatment: Histometric, Tomographic, and Expression Levels of Osteoclastogenic Factors in Osteoporotic Rats

Targeted Drug Delivery from Titanium Implants: A Review of Challenges and Approaches

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