A bacterial endosymbiont of the fungus Rhizopus microsporus drives phagocyte evasion and opportunistic virulence Highlights d Bacterial endosymbionts protect fungal spores from phagocytes d A secreted factor blocks growth and killing by environmental amoebas d Endosymbionts improve fungal stress resistance d Endosymbiosis also allows the evasion of vertebrate immune cells and virulence in vivo