Ralstonia pickettii Bloodstream Infections at a Brazilian Cancer Institution

Pellegrino, Flávia Lúcia Piffano Costa; Schirmer, M.; Velasco, Eduardo; Faria, Lúcia M. de; Santos, Kátia Regina Netto dos; Moreira, Beatriz Meurer

doi:10.1007/s00284-007-9060-1

Cited by 21 publications

(15 citation statements)

References 14 publications

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“…Even ''sterile'' medical products including ranitidine and saline solution had been reported to be contaminated with R. pickettii [31,32]. Several nosocomial catheter-related outbreaks have been described [30,33,34].…”

Section: Biofilm Essaymentioning

confidence: 99%

Molecular investigation of bacterial communities on intravascular catheters: no longer just Staphylococcus

Zhang

Gowardman

Morrison

et al. 2014

Eur J Clin Microbiol Infect Dis

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Intravascular catheter-related bloodstream infections (IVC-BSIs) are associated with significant morbidity and mortality. Culture-independent molecular approaches can reveal and capture the composition of complex microbial communities, and are now being used to reveal "new" pathogens as well as the polymicrobial nature of some infections. Patients with concurrently sited arterial and central venous catheters who had clinically suspected IVC-BSIs, were examined by the high-throughput sequencing of microbial 16S rRNA. An average of 100 operational taxonomic units (OTUs, phylotypes) was observed on each IVC, indicating that IVCs were colonised by complex and diverse bacterial communities. Ralstonia (53 % of 16S rRNA sequences), Escherichia group (16 %), Propionibacterium (5 %), Staphylococcus (5 %), and Streptococcus (2 %) were the most abundant genera. There was no statistically significant difference in the bacterial communities examined from arterial and central venous catheters; from those with and without systemic antibiotic treatment; or from conventionally colonised and uncolonised IVCs. The genome of the predominant bacteria, R. pickettii AU12-08, was found to encode resistance to antimicrobial drugs of different classes. In addition, many encoded gene products are involved in quorum sensing and biofilm formation that would further contribute to increased antimicrobial drug resistance. Our results highlight the complex diversity of microbial ecosystems on vascular devices. High-throughput sequencing of 16S rRNA offers an insight into the pathogenesis of IVC-related infections, and opens up the scope for improving diagnosis and patient management.

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Section: Biofilm Essaymentioning

confidence: 99%

Molecular investigation of bacterial communities on intravascular catheters: no longer just Staphylococcus

Zhang

Gowardman

Morrison

et al. 2014

Eur J Clin Microbiol Infect Dis

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show abstract

“…Ralstonia spp. cannot be considered as innocent bystanders or contaminants, rather they are emerging pathogens associated with the delivery of high-tech medicine in the immunocompromised host and neonates [11,12,14,18]. However, early detection of Ralstonia pickettii allows prompt and directed antibacterial treatment according to sensitivity testing and, in combination with appropriate surgical management, is associated with a favourable outcome.…”

Section: Discussionmentioning

confidence: 99%

Ralstonia Pickettii Meningitis in a Child with Hydrocephalus

Bonatti¹,

Stelzmueller²,

Laimer³

et al. 2009

Eur J Pediatr Surg

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“…25 In a review of 11 cases by Mikulska et al, Ralstonia was susceptible to aminoglycosides, fluoroquinolones, thirdand fourth-generation cephalosporins, piperacillin-tazobactam, and carbapenems, while also resistant to aztreonam. 26…”

Section: Treatmentmentioning

confidence: 99%

Uncommon Pathogens Causing Hospital-Acquired Infections in Postoperative Cardiac Surgical Patients

et al. 2019

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Bacterial infections are common causes of sepsis in the intensive care units. However, usually a finite number of Gram-negative bacteria cause sepsis (mostly according to the hospital flora). Some organisms such as Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus are relatively common. Others such as Stenotrophomonas maltophilia, Chryseobacterium indologenes, Shewanella putrefaciens, Ralstonia pickettii, Providencia, Morganella species, Nocardia, Elizabethkingia, Proteus, and Burkholderia are rare but of immense importance to public health, in view of the high mortality rates these are associated with. Being aware of these organisms, as the cause of hospital-acquired infections, helps in the prevention, treatment, and control of sepsis in the high-risk cardiac surgical patients including in heart transplants. Therefore, a basic understanding of when to suspect these organisms is important for clinical diagnosis and initiating therapeutic options. This review discusses some rarely appearing pathogens in our intensive care unit with respect to the spectrum of infections, and various antibiotics that were effective in managing these bacteria.

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Ralstonia pickettii Bloodstream Infections at a Brazilian Cancer Institution

Cited by 21 publications

References 14 publications

Molecular investigation of bacterial communities on intravascular catheters: no longer just Staphylococcus

Molecular investigation of bacterial communities on intravascular catheters: no longer just Staphylococcus

Ralstonia Pickettii Meningitis in a Child with Hydrocephalus

Uncommon Pathogens Causing Hospital-Acquired Infections in Postoperative Cardiac Surgical Patients

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