Ramadan Fasting Effects on Metabolic Parameters in Elderly Persons With Cardiovascular Risk Factors

Baccouche, Houda; Hellara, Ilhem; Khochtali, I.; Grissa, Mohamed Habib; Boubaker, Hamdi; Beltaïef, Kaouthar; Bouida, Wahid; Najjar, F.; Boukef, Riadh; Hassine, Mohsen; Nouira, S

doi:10.14283/jarcp.2014.35

Cited by 4 publications

(8 citation statements)

References 31 publications

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“…It is worth noting that in this study only 50% of the people had T2D. 16 The studies reporting the effect of Ramadan fasting/intermittent fasting on lipid parameters yielded conflicting results which might be attributed to inclusion of populations with mixed risk factors in some of these studies, small sample size in others, and to differences in dietary habits and physical activities across studies. 4 The significant rise of lipid parameters in our study could be attributed to the nature of dietary habits among Egyptians during Ramadan.…”

Section: Discussionmentioning

confidence: 65%

Ramadan in Egyptian people with type 2 diabetes: effect on cardiometabolic parameters

et al. 2022

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Background: Most Muslims with diabetes have a strong desire to fast during the month of Ramadan but some cannot perform it because of the risk of complications such as hypoglycemia, hyperglycemia, diabetic ketoacidosis, dehydration and thrombosis. During Ramadan, the meal pattern and fluid intake are markedly altered and there are delayed and shortened periods of sleep. These changes in meal and sleep rhythm could lead to undesirable changes in metabolism and increased risk of complications. Aims: To study the effect of Ramadan fasting on metabolic parameters and cardiovascular disease risk in patients with type 2 diabetes mellitus (T2D). Methods: This cohort study was conducted on 80 people with T2D who were intending to fast during Ramadan in the year 2014; the average number of fasting hours was 15 hours. They were subjected to clinical, anthropometric and laboratory evaluation before and after Ramadan. Results: There were significant increases between pre- and post-Ramadan total cholesterol levels (3.77±1.19 mmol/l vs 5.24±1.03 mmol/l, p< 0.001), triglycerides (1.7±0.95 mmol/l vs 2.22±1.51 mmol/l, p< 0.004), LDL-C (2.03±1.08 mmol/l vs 3.04±1.19 mmol/l, p< 0.001), fasting insulin (6.1±3.7 mu/l vs 12.6±8.2 mu/l, p<0.001), HOMA IR (2.42±1.6 IU vs 7.02±8.9 IU, p< 0.001), creatinine (71.62±17.68 umol/l vs 83.11±26.53 umol/l , p< 0.001 ), systolic blood pressure (SBP) (134.9±10.8 mmHg vs 141.2±11.9 mmHg , p< 0.001 ) and diastolic blood pressure (DBP) ( 94.7±10.7 mmHg vs 101.8±11.3 mmHg, p < 0.001). The 10-year cardiovascular disease risk increased from 5.18±7.8 to 7.6±9.9 (p< 0.001). There was no significant change in body mass index. Conclusion: Ramadan fasting in Egyptian people with T2D appears to have a significant effect on lipid profiles and blood pressure that could adversely impact cardiovascular risk. Current guidance is more focused on glycemic control, with adjustments to oral hypoglycemic agents and insulin dose. Cardiovascular disease risk assessment and guidance prior to Ramadan fasting should not be overlooked.

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Section: Discussionmentioning

confidence: 65%

Ramadan in Egyptian people with type 2 diabetes: effect on cardiometabolic parameters

et al. 2022

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“…Baccouche et al demonstrated that a beneficial effect of Ramadhan fasting in elderly patients with cardiovascular risk factors was observed in the early post-fasting period, including increased HDL-C levels and better glycaemic control. 35 In contrast, the study demonstrated a risk of renal function decrease with a simultaneous increase of glycaemia during the fasting period, which could be risky for diabetic patients. 35 Hypertension and diabetes were found to be the commonest co-morbidities in fasting persons older than 60 years, across numerous studies.…”

Section: The Elderlymentioning

confidence: 77%

“… 35 In contrast, the study demonstrated a risk of renal function decrease with a simultaneous increase of glycaemia during the fasting period, which could be risky for diabetic patients. 35 Hypertension and diabetes were found to be the commonest co-morbidities in fasting persons older than 60 years, across numerous studies. 37 A longitudinal study on 182 fasting subjects aged 60 years and above, found a mild improvement in functional status and somatic complaints (though not statistically significant) with statistically significant improvements in depression, anxiety, insomnia, and social interaction before and after Ramadhan fasting ( p = 0.001, p = 0.001, p = 0.006 and p = 0.002, respectively).…”

Section: The Elderlymentioning

confidence: 77%

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Ramadhan fasting for people living with chronic illness: A narrative literature review

Ras,

Holdman,

Matthews

2024

South African Family Practice

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Muslims constitute approximately 20% of the world’s population. In South Africa, Muslims constitute just under 2% of the total population. Fasting is one of the mandatory activities of adherents of the Islamic faith, where all healthy adult Muslims abstain from food, drink, and sexual activities between dawn and dusk during the month of Ramadhan. Medical doctors are frequently required to provide advice to their Muslim patients about the safety or other health impacts of this type of fasting. This narrative review provides an overview of research conducted on Muslim populations during the fasting period, with special reference to non-communicable diseases (NCDs) that are prevalent in the Muslim community. In the absence of evidence-based clinical guidelines, this article summarises the latest published research on this topic, providing a resource for clinicians and researchers. This paper provides an evidence summary to clinicians when engaging with their patients who may be engaging in Ramadhan fasting, while also identifying gaps in the body of evidence that could inform future research.

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“…2 However, other studies have shown a decrease in kidney function in the elderly during the fasting period. 3 Adequate fluid and protein intakes in elderly patients have a protective effect on kidney function. A study showed that dehydration during Ramadan fasting resulted in reduced creatinine clearance in the elderly.…”

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confidence: 99%

Kidney function profile before, during, and after Ramadan fasting in healthy elderly: a prospective cohort study

et al. 2022

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BACKGROUND Kidney function profile is one of the important parameters in determining the health of the elderly. In Indonesia, no study has been conducted on kidney function profile during Ramadan fasting to determine the safety of Ramadan fasting in the elderly. This study aimed to determine the kidney function profile in the elderly who fasted during Ramadan. METHODS This study used a prospective cohort design. The inclusion criteria were elderly aged >60 years undergoing Ramadan fasting in Jatinegara, Jakarta from April to July 2019. Patients with end-stage renal failure who had an acute infection, hypertension crisis, or refused to participate in the study were excluded. Patients who did not fast for 3 consecutive days were dropped out. The kidney function profile was calculated by the estimated glomerular filtration rate (eGFR) using the CKD-EPI formula 1 week before the first day of Ramadan, 3 weeks after the first day of fasting, and 2 weeks after the last day of fasting. Decreased eGFR was defined as having a minimum of 20% eGFR decline during or after the fasting period. Bivariate analysis was performed using McNemar or Cochran tests. RESULTS 2 patients had eGFR decline during fasting, and 7 patients had eGFR decline after fasting. The median eGFR before, during, and after fasting were 81.5, 88.7, and 76.8 ml/min/1.73 m², respectively. A total of 1.4% of subjects had decreased eGFR during Ramadan, while 9.1% had decreased eGFR after Ramadan. However, the changes were not statistically significant. CONCLUSIONS Although most elderly had lower eGFR following Ramadan fasting compared to before and during Ramadan, only individuals with several comorbidities had significant changes of kidney function.

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Ramadan Fasting Effects on Metabolic Parameters in Elderly Persons With Cardiovascular Risk Factors

Cited by 4 publications

References 31 publications

Ramadan in Egyptian people with type 2 diabetes: effect on cardiometabolic parameters

Ramadan in Egyptian people with type 2 diabetes: effect on cardiometabolic parameters

Ramadhan fasting for people living with chronic illness: A narrative literature review

Kidney function profile before, during, and after Ramadan fasting in healthy elderly: a prospective cohort study

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