Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

Abstract

Cocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-aminobenzoic acid was prepared with solid-state (solvent-free or green-chemistry) grinding approach, and the above cocrystal has been characterized by Raman and terahertz vibrational spectroscopic techniques. Spectral results show that the vibrational modes of the cocrystal within the whole spectral region are different from those of the corresponding parent materials. The dynamic process of such pharmaceutical cocrystal formation has also been monitored directly with Raman spectra. These results offer us unique means for characterizing the cocrystal conformation from the molecule-level, and provides us with rich information about the reaction dynamic of cocrystal formation within pharmaceutical fields.

Cocrystal Formation of Betulinic Acid and Ascorbic Acid: Synthesis, Physico-Chemical Assessment, Antioxidant, and Antiproliferative Activity

“…In addition, multidrug cocrystals may exhibit synergistic or additive pharmacological effects. The design of possible cocrystals involves the evaluation of potential non-covalent and non-ionic intermolecular interactions between two or several active ingredients; in general, cocrystal formers bear functional groups that have the ability to form hydrogen bonds (Du et al, 2016).…”

Solubility enhancement of carvedilol using drug–drug cocrystallization with hydrochlorothiazide

“…In addition, multidrug cocrystals may also offer beneficial synergistic or additive pharmacological outcomes. The design of possible cocrystals involves the evaluation of potential non-covalent and non-ionic intermolecular interactions between two or more active ingredients; in general, cocrystal formers bear functional groups that can form hydrogen bonds [54].…”

Synthesis and Characterization of New Sr3(BO3)2 Crystal for Stimulated Raman Scattering Applications

“…Besides the liquids and gases SRS mediums, solid materials, especially crystals, were applied in SRS. Since the 1980s, several new artificial crystals-Such as Ba(NO 3 ) 2 , BaWO 4 and YVO 4 crystals-Have been studied for SRS applications [10][11][12][13][14][15]. These crystals were revealed to possess many merits for SRS process, including larger Raman gain coefficient, stable thermal and mechanical properties, good chemical stability, non-deliquescence, and small volume etc.…”

“…Different from the optical frequency doubling, SRS is a third-order nonlinear optical process with many advantages such as larger angular acceptance, and no walk-off angle and phase-matching (PM) direction [8]. In the early years, SRS experiments were mostly based on liquids and gases including CH 4 , N 2 , and benzene etc. [9].…”

“…As one of the earliest nonlinear optical processes, in recent years, stimulated Raman scattering (SRS) has become an important and efficient method for frequency conversion to fulfill various applications including optical molecular imaging, structure analysis, biology monitoring, and medical treatment [1][2][3][4][5][6][7]. Different from the optical frequency doubling, SRS is a third-order nonlinear optical process with many advantages such as larger angular acceptance, and no walk-off angle and phase-matching (PM) direction [8].…”