Raman hypermapping of human teeth: Analysis and statistical approaches

Pankrushina, Elizaveta A.; Киселева, Д. В.; Mandra, Yuliya; Ожгихина, Н.

doi:10.1063/5.0032410

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…Pankrushina et al [13] applied Raman spectroscopy to better understand the impact of the structure and composition of enamel and dentine layers on their chemical resistance, mechanical properties, protein alteration and the effects of de-/remineralization processes. Different types of tooth diseases were also investigated: teeth affected by hypoplasia lesions with different severity degrees, and then the authors compared these results with those obtained from eroded and intact sound teeth.…”

Section: Raman Spectroscopy Applied To Dentistrymentioning

confidence: 99%

Application of Unsupervised Multivariate Analysis Methods to Raman Spectroscopic Assessment of Human Dental Enamel

et al. 2021

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This work explores the suitability of data treatment methodologies for Raman spectra of teeth using multivariate analysis methods. Raman spectra were measured in our laboratory and obtained from control enamel samples and samples with a protective treatment before and after an erosive attack. Three different approaches for data treatment were undertaken in order to evaluate the aptitude of distinguishing between groups: A—Principal Component Analysis of the numerical parameters derived from deconvoluted spectra; B—PCA of average Raman spectra after baseline correction; and C—PCA of average raw Raman spectra. Additionally, Hierarchical Cluster Analysis were applied to Raman spectra of enamel measured with different laser wavelengths (638 nm or 785 nm) to evaluate the most suitable choice of illumination. According to the different approaches, PC1 scores obtained between control and treatment group were A—50.5%, B—97.1% and C—83.0% before the erosive attack and A—55.2%, B—93.2% and C—87.8% after an erosive attack. The obtained results showed that performing PCA analysis of raw or baseline corrected Raman spectra of enamel was not as efficient in the evaluation of samples with different treatments. Moreover, acquiring Raman spectra with a 785 nm laser increases precision in the data treatment methodologies.

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Section: Raman Spectroscopy Applied To Dentistrymentioning

confidence: 99%