Raman spectroscopy analysis of human amniotic fluid cells from fetuses with myelomeningocele

Pontiggia, Luca; Michalak-Micka, Katarzyna; Hürlimann, Nadine; Yosef, Hesham K.; Böni, Roland; Klar, Agnes S.; Ehrbar, Martin; Ochsenbein-Kölble, Nicole; Biedermann, Thomas; Moehrlen, Ueli

doi:10.1016/j.yexcr.2024.114048

Experimental Cell Research

2024

DOI: 10.1016/j.yexcr.2024.114048

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Raman spectroscopy analysis of human amniotic fluid cells from fetuses with myelomeningocele

Luca Pontiggia,

Katarzyna Michalak-Micka,

Nadine Hürlimann

et al.

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Advanced Tissue-Engineering Approaches for Prenatal Neurosurgical Management of Spinal Dysraphism

Soltani Khaboushan,

Mohammadi,

Soltani Khaboushan

2024

Advances in Regenerative Medicine and Tissue Engineering [Working Title]

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Spinal dysraphism arises from neural tube closure defects occurring between 2 and 6 weeks of gestation, leading to severe complications after birth. It is typically classified as either open or closed, depending on whether the defect is covered by skin. Despite advances in diagnosis, current methods for detecting spinal dysraphism still lack the necessary sensitivity and specificity, driving the pursuit of more effective treatments. The complications, often arising from incomplete spine and brain formation or the exposure of the spinal cord to neurotoxic amniotic fluid, underscore the critical need for prenatal intervention. Current therapeutic approaches remain inadequate, underscoring the urgent need for novel strategies. Tissue engineering, a promising field of medical innovation, holds significant potential for enhancing neural regeneration and repair. Integrating advanced tissue engineering techniques with existing prenatal neurosurgical treatments offers a transformative opportunity to improve outcomes for patients affected by spinal dysraphism.

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Advanced Tissue-Engineering Approaches for Prenatal Neurosurgical Management of Spinal Dysraphism

Soltani Khaboushan,

Mohammadi,

Soltani Khaboushan

2024

Advances in Regenerative Medicine and Tissue Engineering [Working Title]

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Raman spectroscopy analysis of human amniotic fluid cells from fetuses with myelomeningocele

Cited by 1 publication

References 59 publications

Advanced Tissue-Engineering Approaches for Prenatal Neurosurgical Management of Spinal Dysraphism

Advanced Tissue-Engineering Approaches for Prenatal Neurosurgical Management of Spinal Dysraphism

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