Raman spectroscopy for assessment of bone resection margins in mandibulectomy for oral cavity squamous cell carcinoma

Barroso, Elisa M.; Hove, Ivo ten; Schut, Tom C. Bakker; Mast, Hetty; Lanschot, Cornelia G.F. van; Smits, Roeland W.H.; Verdijk, Robert M.; Hegt, Vincent Noordhoek; Jong, Robert J. Baatenburg de; Wolvius, Eppo B.; Puppels, Gerwin J.; Koljenović, Senada

doi:10.1016/j.ejca.2018.01.068

Cited by 46 publications

(44 citation statements)

References 40 publications

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“…From this, they theorized that the technique could be applied to intraoperative margin assessment . Likewise, they have shown that the technique can be used to assess bony involvement with OSCC, with an accuracy of 95%, sensitivity of 95%, and specificity of 87% . These studies show promise for future clinical application of Raman spectroscopy to intraoperative margin assessment.…”

Section: Resultsmentioning

confidence: 98%

Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions

et al. 2019

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Objective: To discuss the current available techniques for intraoperative margin assessment in the surgical treatment of oral squamous cell carcinoma (OSCC) through a review of the available literature.Methods: A systematic review was undertaken of the available English literature between 2008 through 2018 regarding surgical margins in OCSS. A total of 893 relevant articles were returned; 144 met criteria for review; and 64 articles were included.Results: In this review, we discuss the data surrounding the use of frozen section in OCSS. Additionally, alternative techniques for margin assessment are discussed, including Mohs, molecular analysis, nonfluorescent dyes, fluorescent dyes, autofluorescent imaging, narrow-band imaging, optical coherence tomography, confocal microscopy, high-resolution microendoscopy, and spectroscopy. For each technique, particular emphasis is placed on the local recurrence, disease-free survival, and overall survival rates when available.Conclusion: This review provides support for the practice of specimen-driven margin assessment when using frozen section analysis to improve the utility of the results. Finally, several alternatives for intraoperative margin assessment currently under investigation, including pathologic, wide-field imaging and narrow-field imaging techniques, are presented. We aim to fuel further investigation into methods for margin assessment that will improve survival for patients with OSCC through a critical analysis of the available techniques.

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Section: Resultsmentioning

confidence: 98%

Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions

et al. 2019

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“…Barroso et al investigated the use of Raman spectroscopy for the detection of tumor cells in resection surfaces in 2018. 5 Raman mapping relies on the scattering of light, emitted from a laser, from a material. This scattering is picked up, and molecular mapping can be determined.…”

Section: Discussionmentioning

confidence: 99%

“…3 Rates of bone margin positivity vary significantly in the literature, ranging from as low as 2% to as high as 21%. 3,5 Unlike soft tissue, bone resection margins are not obtainable through frozen sections, due to high mineral content. 6 Therefore, histopathological confirmation of the presence of tumor cells is only available days after surgery.…”

Section: Introductionmentioning

confidence: 99%

“…6 Therefore, histopathological confirmation of the presence of tumor cells is only available days after surgery. 5,6 Despite the importance of margins, and the long latency of traditional histopathological methods, there remain few alternatives for intraoperative assessment of resection margins during mandibulectomy other than conventional visual inspection and palpation, which may be inadequate in many cases. Intraoperative cytological assessment has been described as a promising technique, though may be limited by specimen desiccation or insufficient material.…”

Section: Introductionmentioning

confidence: 99%

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Intraoperative Radiographic Assessment of Bone Resection Margins During Mandibulectomy: A Case Series

et al. 2019

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Background and Purpose: Mandibulectomy remains the treatment of choice for oral cavity squamous cell carcinoma with infiltration of bone and for benign tumors with full mandibular thickness involvement. Although bone resection margins are critical for patient outcomes, intraoperative immediate bone margins assessment is inadequate, and few alternative options have been described. The purpose of this study was to describe the use of an existing intraoperative radiographic system for objective determination of bone resection margins during mandibulectomy. Methods: We conducted a retrospective case series of all patients at the Greater Baltimore Medical Center who underwent mandibulectomy and received intraoperative Faxitron radiography from January 1, 2016, to March 1, 2019. Patient characteristics including age, sex, diagnosis, tumor location, clinical and pathologic stage, procedure performed, and bone resection margins were reviewed. Results: A total of 10 patients underwent mandibulectomy with intraoperative radiography. Nine (90%) received surgery for squamous cell carcinoma, with 1 (10%) for ameloblastoma. Out of those with squamous cell carcinoma, tumor location varied, and all were clinically stage T4. Final pathologic margins were negative in all cases (10/10), though in 2 cases, close margins were assessed intraoperatively, leading to further resection or change in operative plan. Conclusion: Intraoperative radiographic assessment of bone resection margins is a promising technique, though further validation is required.

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“… Positron emission tomography Imaging using radioactive agents Head and neck region (in situ) NA NA Measure cellular-level metabolic changes Early detection Non-invasive Less accurate sometimes Short decay-duration of a radioactive substance Expensive 2000-27000 [ 48 ] 27. Raman spectroscopy Optical spectroscopic technique for chemical analysis Oral tissue Keratin 95 % Minimal sample preparation Highly informative Non-destructive Non-invasive Signal inadequacy Bands overlap, difficulty in identifying individual component 1000 [ 49 , 50 ] 28. Spectral cytopathology Micro-spectral measurement and multivariate data analysis Oral cells Proteins NA Accurate and reproducible Less human error Expensive - [ 51 ] 29.…”

Section: Techniques Used For Diagnosis Of Oral Cancermentioning

confidence: 99%

Oral cancer diagnosis and perspectives in India

Borse

Konwar

Buragohain

2020

Sensors International

258

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Globally, oral cancer is the sixth most common type of cancer with India contributing to almost one-third of the total burden and the second country having the highest number of oral cancer cases. Oral squamous cell carcinoma (OSCC) dominates all the oral cancer cases with potentially malignant disorders, which is also recognized as a detectable pre-clinical phase of oral cancer. Tobacco consumption including smokeless tobacco, betel-quid chewing, excessive alcohol consumption, unhygienic oral condition, and sustained viral infections that include the human papillomavirus are some of the risk aspects for the incidence of oral cancer. Lack of knowledge, variations in exposure to the environment, and behavioral risk factors indicate a wide variation in the global incidence and increases the mortality rate. This review describes various risk factors related to the occurrence of oral cancer, the statistics of the distribution of oral cancer in India by various virtues, and the socio-economic positions. The various conventional diagnostic techniques used routinely for detection of the oral cancer are discussed along with advanced techniques. This review also focusses on the novel techniques developed by Indian researchers that have huge potential for application in oral cancer diagnosis.

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Raman spectroscopy for assessment of bone resection margins in mandibulectomy for oral cavity squamous cell carcinoma

Cited by 46 publications

References 40 publications

Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions

Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions

Intraoperative Radiographic Assessment of Bone Resection Margins During Mandibulectomy: A Case Series

Oral cancer diagnosis and perspectives in India

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