Raman Spectroscopy in the Diagnosis of Ulcerative Colitis

Veenstra, Michelle; Palyvoda, Olena; Alahwal, Hazem; Jovanovski, M; Reisner, Luke A.; King, Brady W.; Poulik, Janet; Klein, Michael D.

doi:10.1055/s-0034-1387951

Cited by 8 publications

(10 citation statements)

References 14 publications

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“…In one of the first studies published on the topic, using colorectal biopsy specimens from 8 patients who underwent surgery, Veenstra et al [8] managed to differentiate subjects with UC from healthy subjects with a sensitivity of 82% and a specificity of 89%, with significant differences in the spectral regions associated with nucleic acids (1,044 cm -1 ), lipids (1,102 and 1,656-1,658 cm -1 ) and proteins (755, 1,030-1,032, 1,102, 1,170-1,173, 1,246, 1,613 and 1,656-1,658 cm -1 ), explained by the development of inflammation and increased cell turnover.…”

Section: Discussionmentioning

confidence: 99%

Clinical Applications of Raman Spectroscopy in Inflammatory Bowel Diseases. A Review

Tefas

Tanţău

2018

JGLD

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Background & Aims: Inflammatory bowel diseases are still difficult to diagnose and differentiate in some cases despite the serological, imaging, endoscopic and histopathological armamentarium. Raman spectroscopy is a technique that could help with these shortcomings. The aim of this paper is to present the accuracy of Raman spectroscopy in the diagnosis and monitoring of patients with inflammatory bowel diseases.Methods: We identified the published manuscripts and abstracts up to the 31st of December 2017 by a systematic search of Medline, Embase, Cochrane and other trial registries.Results: Eight publications were found, showing sensitivities and specificities of Raman spectroscopy in diagnosing and differentiating inflammatory bowel diseases ranging from 82 to 99% and 57 to 99%, respectively, and accuracies of up to 95%.Conclusion: The technique has so far proven its potential in the positive and differential diagnosis of Crohn’s disease or ulcerative colitis, allowing for very rapid results with high sensitivity and specificity.

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Section: Discussionmentioning

confidence: 99%

Clinical Applications of Raman Spectroscopy in Inflammatory Bowel Diseases. A Review

Tefas

Tanţău

2018

JGLD

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“…The authors collected UC and HC tissue samples and examined the mucosal and serosal surfaces, achieving a classification sensitivity of 82% and a specificity of 89% from the mucosal surface and 87% sensitivity and 93% specificity from the serosal surface. 70 Their study indicated the possibility of real-time diagnosis with the ability to observe changes within UC colon tissue which are not apparent in histological examination. Spectral areas of interest revealed significant changes in peaks assigned as proteins, lipids and nucleic acids due to the increase in levels of inflammation.…”

Section: Ibd Diagnosis and Discriminationmentioning

confidence: 99%

“…demonstrating one of the first such applications. The authors collected UC and HC tissue samples and examined the mucosal and serosal surfaces, achieving a classification sensitivity of 82% and a specificity of 89% from the mucosal surface and 87% sensitivity and 93% specificity from the serosal surface 70 . Their study indicated the possibility of real‐time diagnosis with the ability to observe changes within UC colon tissue which are not apparent in histological examination.…”

Section: Applicationsmentioning

confidence: 99%

Review–Vibrational spectroscopy‐aided diagnosis, prognosis and treatment of inflammatory bowel disease

Buchan,

Oppenheimer

2023

Clinical and Translational Dis

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BackgroundInflammatory bowel disease (IBD) represents a group of chronic gastrointestinal disorders characterised by complex and multifaceted pathologies. The pursuit of non‐invasive, accurate and rapid diagnostic methods and therapeutic monitoring tools has led to the emergence of Raman spectroscopy (RS) as a promising analytical technique in the field of IBD. RS offers molecular specificity with the potential to uncover valuable insights of the pathophysiology of IBD, posing it as a rapidly growing field of interest in both research and clinical settings.MainThis comprehensive review aims to provide an overview of the current state of research in the field of IBD‐RS, with an emphasis on its potential diagnostic, prognostic, and therapeutic monitoring capabilities. We explore the molecular characterisation of bodily fluids including blood, urine and saliva and the ability of RS to rapidly determine the underpinning biochemical changes in their composition. The review also highlights recent studies and advances, that have employed RS to differentiate between healthy and diseased states, classify the IBD subtypes, identify candidate biomarkers and to monitor the therapeutic response to treatment in the form of mucosal healing. Additionally, we comment on the challenges and limitations associated with current research as well as with the clinical translation of RS for IBD diagnosis.ConclusionsAs the field of vibrational spectroscopies continues to evolve particularly in the broader IBD context, to aid the diagnosis, prognosis and treatment, this review serves as a valuable resource for clinicians and researchers alike, examining the potential of Raman‐based spectroscopy and the emerging technologies to advance the understanding and triaging of IBD. Ultimately, the integration of RS into everyday clinical practice holds promise for more effective management of IBDs, addressing the major unmet need in the fields of gastroenterology and of clinical medicine as a whole.

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“…Pre-malignant stages of colorectal cancer can also benefit from the use of RS. Veenstra et al [ 15 ] evaluated the spectra of patients with ulcerative colitis, focusing on the mucosal and serosal regions. Regarding the mucosa, RS had a sensitivity of 82% and specificity of 89%.…”

Section: Colonmentioning

confidence: 99%

“…Regarding the mucosa, RS had a sensitivity of 82% and specificity of 89%. For the serosal regions, RS had a sensitivity of 87% and a specificity of 93% [ 15 ].…”

Section: Colonmentioning

confidence: 99%

Raman Spectroscopy for the Endoscopic Diagnosis of Esophageal, Gastric, and Colonic Diseases

Sharma

Takeshita

2016

Clin Endosc

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Globally white-light endoscopy with biopsy sampling is the gold standard diagnostic modality for esophageal, gastric, and colonic pathologies. However, there is overwhelming evidence to highlight the deficiencies of an approach based predominantly on eyeball visualization. Biopsy sampling is also problematic due in part to excessive sampling and hence attendant cost. Various innovations are currently taking place in the endoscopic domain to aid operators in diagnosis forming. These include narrow band imaging which aims to enhance the surface anatomy and vasculature, and confocal laser endomicroscopy which provides real time histological information. However, both of these tools are limited by the skill of the operator and the extensive learning curve associated with their use. There is a gap therefore for a new form of technology that relies solely on an objective measure of disease and reduces the need for biopsy sampling. Raman spectroscopy (RS) is a potential platform that aims to satisfy these criteria. It enables a fingerprint capture of tissue in relation to the protein, DNA, and lipid content. This focused review highlights the strong potential for the use of RS during endoscopic gastroenterological examination.

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Raman Spectroscopy in the Diagnosis of Ulcerative Colitis

Abstract: Raman spectroscopy can distinguish UC from normal colon tissue rapidly and accurately. This technology offers the possibility of real-time diagnosis as well as the ability to study changes in UC-afflicted colon tissue that do not appear histologically.

Cited by 8 publications

References 14 publications

Clinical Applications of Raman Spectroscopy in Inflammatory Bowel Diseases. A Review

Clinical Applications of Raman Spectroscopy in Inflammatory Bowel Diseases. A Review

Review–Vibrational spectroscopy‐aided diagnosis, prognosis and treatment of inflammatory bowel disease

Raman Spectroscopy for the Endoscopic Diagnosis of Esophageal, Gastric, and Colonic Diseases

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