Raman spectroscopy of serum: A study on ‘pre’ and ‘post’ breast adenocarcinoma resection in rat models

Bhattacharjee, Tanmoy; Khan, Aysha; Kumar, Piyush; Ingle, Arvind; Maru, Girish B.; Krishna, C. Murali

doi:10.1002/jbio.201400040

Cited by 8 publications

(3 citation statements)

References 51 publications

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“…Interestingly, although NR serum exhibits differences in post‐surgery serum biochemical profile compared to R subjects, the AS serum of NR is not identical to H serum with respect to its biochemical composition. A previous study has also shown similar findings in mouse models for breast cancer 37 . In the present study, greater DNA and protein content were observed in the NR serum compared to H serum.…”

Section: Discussionsupporting

confidence: 91%

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Serum Raman spectroscopy: Prognostic applications in oral cancers

et al. 2023

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Background Loco‐regional recurrences attributable to field cancerization and minimal residual cancer, remain prime causes of mortality in oral cancer (OC) subjects. The current study evaluates potential of serum Raman spectroscopy (SRS) to identify recurrence‐prone OC subjects. Methods Raman spectra of serum from eight healthy subjects (H) and 57 OC subjects (with‐recurrence [R], without‐recurrence [NR], and with suspicious‐lesions [S]), before (BS) and after (AS) surgical excision of tumor were recorded. OC subjects were followed‐up for 7‐years. Results DNA and protein alterations were observed in AS sera of all groups. 4‐, 3‐, and 2‐model multivariate analyses were used to stratify BS and AS groups. H spectra were 100% distinguishable from all other groups. AS, R and NR were distinguished with high accuracy (84%) in all models. No stratification (~50%) was observed BS. Conclusion SRS shows potential to identify recurrence prone subjects, post‐surgery, using serum collected as early as 1 week after surgery.

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Section: Discussionsupporting

confidence: 91%

“…A previous study has also shown similar findings in mouse models for breast cancer. 37 In the present study, greater DNA and protein content were observed in the NR serum compared to H serum. Lower beta-carotene content was observed in NR serum compared to H serum, from the difference spectrum.…”

Section: Raman Spectral Analysessupporting

confidence: 51%

Serum Raman spectroscopy: Prognostic applications in oral cancers

et al. 2023

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“…Spectroscopy is a promising method for fast and reliable diagnostics in nonlaboratory settings . Raman spectroscopy has the major advantage of being rather unsusceptible to aqueous environments , because the Raman cross-section of water is relatively small . Furthermore, Raman measurements require less sample preparation and no complex laboratory infrastructure.…”

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confidence: 99%

LOC-SERS: A Promising Closed System for the Identification of Mycobacteria

et al. 2016

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A closed droplet based lab-on-a-chip (LOC) device has been developed for the differentiation of six species of mycobacteria, i.e., both Mycobacterium tuberculosis complex (MTC) and nontuberculous mycobacteria (NTM), using surface-enhanced Raman spectroscopy (SERS). The combination of a fast and simple bead-beating module for the disruption of the bacterial cell with the LOC-SERS device enables the application of an easy and reliable system for bacteria discrimination. Without extraction or further treatment of the sample, the obtained SERS spectra are dominated by the cell-wall component mycolic acid. For the differentiation, a robust data set was recorded using a droplet based LOC-SERS device. Thus, more than 2100 individual SERS spectra of the bacteria suspension were obtained in 1 h. The differentiation of bacteria using LOC-SERS provides helpful information for physicians to define the conditions for the treatment of individual patients.

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