Abstract:Three new jatropholane-type diterpenoids, jatropholones C-E (1-3), along with seven other known compounds, including sikkimenoid B (4), jatrophaldehyde (5), epi-jatrophaldehyde (6), epi-jatrophol (7), jatrophol (8), jatropholone A (9), and jatropholone B (10), were isolated from the roots of a natural cultivar of Jatropha curcas (J. curcas cv. Multiflorum CY Yang). The structural elucidations of 1-3 were accomplished by extensive NMR analysis. Compounds 4, 6, and 8 demonstrated inhibition activity against the microorganisms with the MIC values from 0.10 to 0.18 mg/mL.
Keywords: Jatropha curcas cv. Multiflorum, Euphorbiaceae, diterpenes, antibacterial
IntroductionThe genus Jatropha belonging to the family Euphorbiaceae contains a number of traditionally important medicinal plants. Approximately 170 species are found in tropical Asia and Africa, while only three common cultivated and three wild species (J. curcas, J. podagrica, and J. multifida), together with two cultivated species (J. gossypifolia and J. integerrima) distributed in China. J. curcas and J. podagrica, have been used as Chinese traditional medicines for the treatment of injuries swelling, fracture, skin itching, eczema, and acute gastroenteritis embolism 1 . Recently, two natural cultivars of J. curcas (J. curcas cv. Multiflorum CY Yang and J. nigroviensrugosus CY Yang) were discovered in the Yuanjiang River, Yunnan province and had been registered as new cultivars