Ramosetron as a Treatment for Cyclic Vomiting Syndrome: A Small-Scale Patient Trial

Hikita, Toshiyuki; Hoshino, Hideki; Mimaki, Masakazu

doi:10.1177/2333794x20969281

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…5-HT has been linked to the pathogenesis of several functional bowel disorders, including irritable bowel syndrome and cyclic vomiting. Patients with CVS improve with therapy including 5-HT receptor antagonists [ 36 ].…”

Section: Reviewmentioning

confidence: 99%

Charles Darwin’s Mitochondrial Disorder: Possible Neuroendocrine Involvement

Hayman¹,

Finsterer²

2021

Cureus

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Charles Darwin, the famous naturalist, suffered relapsing, debilitating illness for most of his adult life with a plethora of symptoms. The diagnosis favoured here for this illness is that of an adult-onset mitochondrial disorder due to a maternally inherited, pathological mitochondrial DNA mutation clinically manifesting as MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) syndrome. This diagnosis accounts for Darwin’s primary symptoms; in addition, it accounts for the various unusual illnesses that afflicted his siblings and maternal (Wedgwood) ancestors. Symptoms of Darwin’s illness may be related to dysfunction of cells with high energy requirements; this includes cells constituting the cardiac conduction system, cerebral endothelial cells, neurons, neuroepithelial cells of the vestibular apparatus, and, as proposed here, central and peripheral neuroendocrine cells. Although Darwin’s episodes of sudden facial flushing, his nocturnal panic attacks, and his severe gastrointestinal symptoms are not readily explained, these symptoms may relate to neuroendocrine dysfunction, either an uncontrolled release of stimulatory hormone or impaired inhibitory control. It is also conceivable that the autonomic system had been involved. A study of Darwin’s illness may benefit those who suffer from similar symptoms today.

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Section: Reviewmentioning

confidence: 99%

Charles Darwin’s Mitochondrial Disorder: Possible Neuroendocrine Involvement

Hayman¹,

Finsterer²

2021

Cureus

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“…Topiramate is recommended as an alternate prophylactic medication along with aprepitant, zonisamide, and levetiracetam 1 . Newer remedies like ramosetron 2 and ketamine 3 have also been proposed. Notably, however, there is a paucity of studies to support the use of these medications for CVS.…”

mentioning

confidence: 99%