2016
DOI: 10.1093/annonc/mdw423
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Ramucirumab combined with FOLFOX as front-line therapy for advanced esophageal, gastroesophageal junction, or gastric adenocarcinoma: a randomized, double-blind, multicenter Phase II trial

Abstract: NCT01246960.

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Cited by 141 publications
(115 citation statements)
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References 16 publications
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“…Conversely, combination therapies between platinum-based chemotherapy and anti-angiogenic agents in first-line treatment of GC have failed to show significant survival benefit [40,41,51]. Additionally, the first report on ramucirumab in combination with a platinum compound, such as oxaliplatin, did not meet its primary endpoint [50]. Therefore, a randomized, double-blind, placebo-controlled phase III study of cisplatin plus a fluoropyrimidine with or without ramucirumab as first-line therapy in patients with metastatic GC or GEJ adenocarcinoma (RAINFALL, NCT02314117) is currently recruiting participants, and the final results of this trial are awaited to make definitive conclusions about platinumbased chemotherapy and antiangiogenic agents in first-line treatment of GC.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Conversely, combination therapies between platinum-based chemotherapy and anti-angiogenic agents in first-line treatment of GC have failed to show significant survival benefit [40,41,51]. Additionally, the first report on ramucirumab in combination with a platinum compound, such as oxaliplatin, did not meet its primary endpoint [50]. Therefore, a randomized, double-blind, placebo-controlled phase III study of cisplatin plus a fluoropyrimidine with or without ramucirumab as first-line therapy in patients with metastatic GC or GEJ adenocarcinoma (RAINFALL, NCT02314117) is currently recruiting participants, and the final results of this trial are awaited to make definitive conclusions about platinumbased chemotherapy and antiangiogenic agents in first-line treatment of GC.…”
Section: Discussionmentioning
confidence: 99%
“…In a doubleblind, phase II trial, 168 patients with previously untreated unresectable locally advanced or metastatic esophageal, GC, or EGJ adenocarcinoma were randomized to receive mFOLFOX6 plus ramucirumab or placebo [50]. One hundred sixty-eight patients were enrolled (84 in the experimental arm vs. 84 in the chemotherapy ?…”
Section: Ramucirumabmentioning
confidence: 99%
“…По результатам рандомизированных исследований III фазы оба препа-рата зарегистрированы только в сочетании с режимом FOLFIRI во второй линии терапии [19,20]. Эффектив-ность данных моноклональных антител в первой линии или в комбинациях с оксалиплатин-содержащими режи-мами не доказана [21][22][23][24].…”
Section: какой режим химиотерапии лучше комбинировать с таргетным преunclassified
“…[25][26][27][28][29][30][31][32][33][34][35][36][37]44,[51][52][53][54][55][56][57][58][59] The TYTAN trial missed data about PFS. One trial missed results about OS.…”
Section: Studies Selectionmentioning
confidence: 99%