RanBPM Contributes to Semaphorin3A Signaling through Plexin-A Receptors

Togashi, Hideaki; Schmidt, Eric F.; Strittmatter, Stephen M.

doi:10.1523/jneurosci.0704-06.2006

Cited by 74 publications

(78 citation statements)

References 53 publications

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“…For example, Ran can associate with a centromeric protein AKAP450, and become accumulated at the centromere to facilitate cytoskeleton assembling, consequently participating in cell division (Keryer et al, 2003). Ran can also associate with RanBPM, which interacts with adhesion molecule L1 and axon guidance receptor plexin A1, thereby affecting the growth of neurons (Cheng et al, 2005;Togashi et al, 2006). In this study, we identified Arl6ip1 as a binding partner of Ran and found that the binding between Arl6ip1 and Ran was most likely direct.…”

Section: Ran Associates With Various Binding Partners To Play Distincmentioning

confidence: 72%

“…For example, evidences indicate that Ran promotes tubulin polymerization and, consequently, stabilizes the microtubule structure (Dasso, 2001;Sazer & Dasso, 2000). Additionally, Ran and its binding protein RanBPM have been reported to play roles in signal transduction and affect the differentiation of neurons (Cheng et al, 2005;Togashi et al, 2006). Recently, the overexpression of Ran has also been linked to cancer progression (Deng et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Ras-Related Nuclear Protein is required for late developmental stages of retinal cells in zebrafish eyes

Lin

Huang

Lu³

et al. 2015

Int. J. Dev. Biol.

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Ras-related nuclear protein (Ran) is involved in cell division by regulating nucleocytoplasmic transport and modulating the assembly of tubulin. However, its function in embryonic development is unclear. We used zebrafish to study the roles of Ran in eye development. The ran transcripts were restrictedly expressed in head and eyes after the pharyngula stage. The microphthalmos, in which no ordered layers with differentiated retinal cells were detected, was observed in the ran-deficient embryos. They exhibited faster decline cyclinD1-expressed cells, suggesting that cell cycle regulation in retinae was defective. The apoptotic signals in the retinae of ran-deficient embryos remained low at early (24 hpf) stage. Early eye field specification markers, rx1 and pax6, were only slightly affected, and markers for establishing axon migration, fgf8 and pax2, were normally expressed, suggesting Ran is not required in the early stages of eye development. However, the early optic nerve differentiation marker p57kip2 was not expressed at middle (48 hpf) and late (72 hpf) stages. We also observed a decrease in the retinal neuron proteins HuC and Neurolin. The proneural gene ath5, which first determines the cell fate of the developing ganglion cell layer, was undetectable. Furthermore, we found that Ran was associated with ADP-ribosylation factor-like protein 6-interacting protein 1 (Arl6ip1), which plays a role in retinal development, suggesting that Ran associates with Arl6ip1 to regulate retinal development. Therefore, while the effects of Ran are minimal during early specification of the eye field, Ran is required for proliferation and differentiation of retinal cells at later developmental stages.

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Section: Ran Associates With Various Binding Partners To Play Distincmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Ras-Related Nuclear Protein is required for late developmental stages of retinal cells in zebrafish eyes

Lin

Huang

Lu³

et al. 2015

Int. J. Dev. Biol.

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“…The rostrocaudal expression levels of Sema3A, ephrinA5, and their receptors may render CHL1/Npn1 the predominant guidance system for VB axon sorting at the VTe. Differential expression of plexinAs (Yaron et al, 2005), MICALs (molecules interacting with CASL) (Pasterkamp et al, 2006), or RanBPM (Togashi et al, 2006), which bind Npn1, might also influence CHL1 interaction with Npn1 and downstream signaling. Caudal thalamic axons might rely on other guidance factors for rostrocaudal sorting in the VTe, for example netrin-1 (Braisted et al, 2000) or other semaphorins.…”

Section: Discussionmentioning

confidence: 99%

Close Homolog of L1 and Neuropilin 1 Mediate Guidance of Thalamocortical Axons at the Ventral Telencephalon

Wright¹,

Demyanenko²,

Powell³

et al. 2007

J. Neurosci.

126

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We report a cooperation between the neural adhesion molecule close homolog of L1 (CHL1) and the semaphorin 3A (Sema3A) receptor, neuropilin 1 (Npn1), important for establishment of area-specific thalamocortical projections. CHL1 deletion in mice selectively disrupted the projection of somatosensory thalamic axons from the ventrobasal (VB) nuclei, causing them to shift caudally and target the visual cortex. At the ventral telencephalon, an intermediate target with graded Sema3A expression, VB axons were caudally shifted in CHL1 Ϫ embryos and in Npn1 SemaϪ/Ϫ mutants, in which axons are nonresponsive to Sema3A. CHL1 colocalized with Npn1 on thalamic axons, and associated with Npn1 through a sequence in the CHL1 Ig1 domain that was required for Sema3A-induced growth cone collapse. These results identify a novel function for CHL1 in thalamic axon responsiveness to ventral telencephalic cues, and demonstrate a role for CHL1 and Npn1 in establishment of proper targeting of specific thalamocortical projections.

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“…After the binding of Sema3A to the coreceptor complex consisting of members of the Plexin-A (PlexA) and neuropilin-1 (NRP1) families of proteins (He and Tessier-Lavigne, 1997;Kolodkin et al, 1997;Takahashi et al, 1999;Tamagnone et al, 1999), neuronal growth cones collapse as a result of the dramatic rearrangement of the actin cytoskeleton and endocytosis of the plasma membrane (Luo et al, 1993;Fournier et al, 2000;Jurney et al, 2002;Castellani et al, 2004). A role for Rho-like GTPases (Jin and Strittmatter, 1997;Zanata et al, 2002;Turner et al, 2004;Toyofuku et al, 2005), protein phosphorylation (Aizawa et al, 2001;Eickholt et al, 2002;Mitsui et al, 2002;Sasaki et al, 2002), RanBPM (Togashi et al, 2006), and members of the collapsin response mediator protein (CRMP) family (Goshima et al, 1995;Deo et al, 2004) have all been shown to play a role in Sema3A signal transduction. In addition, the intracellular molecule interacting with CasL (MICAL) has been shown to bind to PlexA receptors in Drosophila and is required for proper guidance of motor axons (Terman et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Release of MICAL Autoinhibition by Semaphorin-Plexin Signaling Promotes Interaction with Collapsin Response Mediator Protein

Schmidt¹,

Shim²,

2008

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RanBPM Contributes to Semaphorin3A Signaling through Plexin-A Receptors

Cited by 74 publications

References 53 publications

Ras-Related Nuclear Protein is required for late developmental stages of retinal cells in zebrafish eyes

Ras-Related Nuclear Protein is required for late developmental stages of retinal cells in zebrafish eyes

Close Homolog of L1 and Neuropilin 1 Mediate Guidance of Thalamocortical Axons at the Ventral Telencephalon

Release of MICAL Autoinhibition by Semaphorin-Plexin Signaling Promotes Interaction with Collapsin Response Mediator Protein

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