RanBPM inhibits BLT2-mediated IL-8 production and invasiveness in aggressive breast cancer cells

Wei, Jun; Jang, Jae Hyun; Kim, Jae Hong

doi:10.1016/j.bbrc.2016.12.147

Cited by 5 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The loss of RanBPM in the lung adenocarcinoma cancer cells (A549) resulted in a slightly decreased migration, whereas a marked increase was seen in the RanBPM-knockdown SKMES1 cells. A recent study showed that RanBPM inhibits BLT2-mediated IL-8 production and invasiveness in aggressive breast cancer cells (21). In our experiments, the knockdown of RanBPM promoted the invasion of A549 cells which was not observed in the SKMES1 cells.…”

Section: Discussioncontrasting

confidence: 53%

“…RanBPM is ubiquitously expressed in human and murine cell lines and has been observed in the cytoplasm, nucleus and plasma membrane. Overexpression of RanBPM has been evident in certain cancers and is also associated with the invasion of certain cancers (20,21). In the present study, we investigated the role of RanBPM in lung cancer.…”

Section: Discussionmentioning

confidence: 95%

“…RanBPM regulates numerous cellular processes by interacting with different proteins, such as gene expression, signal transduction, cell adhesion, invasion and migration. To date, its biological functions remain largely unknown (18)(19)(20)(21)(22).…”

mentioning

confidence: 99%

“…In human and murine cell lines, RanBPM is ubiquitously expressed and has been detected at the nucleus, cytoplasm, plasma membrane, and cell junctions (23)(24)(25)(26). In an exploration of its involvement in malignancies, RanBPM has been shown to be a negative regulator of BLT2 (leukotriene B4 receptor 2) which inhibits interleukin 8 (IL-8) production and reactive oxygen species (ROS) generation leading to an increase of invasiveness and other aggressive traits of breast cancer cells (21). Similarly, its expression is also associated with distant metastasis in gastric cancers.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Reduced Expression of RanBPM Is Associated with Poorer Survival from Lung Cancer and Increased Proliferation and Invasion of Lung Cancer Cells In Vitro

Zhao

Cheng

Zabkiewicz

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Reduced Expression of RanBPM Is Associated with Poorer Survival from Lung Cancer and Increased Proliferation and Invasion of Lung Cancer Cells In Vitro

Zhao

Cheng

Zabkiewicz

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Recent work by Nhek et al shows that activated platelets can increase IL-8 in endothelial cells in a model of lupus. 43 IL-8 in vitro increases tumor cell invasion, angiogenesis, and the expansion of cancer stem cells, [44][45][46][47][48] whereas blockade of IL-8 receptors CXCR1 and CXCR2 is associated with antitumor effects. 49,50 In this study, we show that platelet-mediated release of IL-8 from breast cancer cells drives cancer cell invasion and metastasis (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis

et al. 2019

View full text Add to dashboard Cite

It is now recognized that compounds released from tumor cells can activate platelets, causing the release of platelet-derived factors into the tumor microenvironment. Several of these factors have been shown to directly promote neovascularization and metastasis, yet how the feedback between platelet releasate and the tumor cell affects metastatic phenotype remains largely unstudied. Here, we identify that breast tumor cells secrete high levels of interleukin 8 (IL-8, CXCL8) in response to platelet releasate, which promotes their invasive capacity. Furthermore, we found that platelets activate the Akt pathway in breast tumor cells, and inhibition of this pathway eliminated IL-8 production. We therefore hypothesized inhibiting platelets with aspirin could reverse the prometastatic effects of platelets on tumor cell signaling. Platelets treated with aspirin did not activate the Akt pathway, resulting in reduced IL-8 secretion and impaired tumor cell invasion. Of note, patients with breast cancer receiving aspirin had lower circulating IL-8, and their platelets did not increase tumor cell invasion compared with patients not receiving aspirin. Our data suggest platelets support breast tumor metastasis by inducing tumor cells to secrete IL-8. Our data further support that aspirin acts as an anticancer agent by disrupting the communication between platelets and breast tumor cells.

show abstract

A Comprehensive Bioinformatic Analysis of RanBP9 Expression and Its Relation to Prognosis in Human Breast Cancer

et al. 2021

View full text Add to dashboard Cite

Aim: To explore the role of RanBP9 in breast cancer. Materials & methods: Oncomine, TIMER, GEPIA, UALCAN, c-BioPortal databases and tissue microarray analysis were used in this study. Results: The expression level of RanBP9 is elevated in breast cancer tissues, which is associated with poor prognosis in breast cancer patients. RanBP9 exhibits genetic alterations and a decreased methylation level in cancer tissues. RanBP9 may also regulate cell cycle progression and is linked to tumor purity and the infiltrating levels of immune cells. Conclusions: RanBP9 may correlate with prognosis and immune infiltration in breast cancer, laying the foundation for future studies on the potential role of RanBP9 in breast cancer.

show abstract

RanBPM inhibits BLT2-mediated IL-8 production and invasiveness in aggressive breast cancer cells

Cited by 5 publications

References 31 publications

Reduced Expression of RanBPM Is Associated with Poorer Survival from Lung Cancer and Increased Proliferation and Invasion of Lung Cancer Cells In Vitro

Reduced Expression of RanBPM Is Associated with Poorer Survival from Lung Cancer and Increased Proliferation and Invasion of Lung Cancer Cells In Vitro

Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis

A Comprehensive Bioinformatic Analysis of RanBP9 Expression and Its Relation to Prognosis in Human Breast Cancer

Contact Info

Product

Resources

About