Random Forest Regression-Based Fault Location Scheme for Transmission Lines

Bhatnagar, Maanvi; Yadav, Anamika; Swetapadma, Aleena

doi:10.1007/978-981-19-2764-5_17

Cited by 2 publications

(1 citation statement)

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“…With the increase in drug combination data, machine learning (ML) methods provide a more powerful predicting capability [ 12 ]. Drug combination prediction algorithms are developed by traditional ML methods, such as Random Forest (RF) [ 13 ], support vector machine (SVM) [ 14 ], XGBoost and so on [ 15 ]. In the recent years, deep learning (DL) methods show superior performance compared to traditional ML.…”

Section: Introductionmentioning

confidence: 99%

DEML: Drug Synergy and Interaction Prediction Using Ensemble-Based Multi-Task Learning

Wang

Dong²,

et al. 2023

Molecules

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Synergistic drug combinations have demonstrated effective therapeutic effects in cancer treatment. Deep learning methods accelerate identification of novel drug combinations by reducing the search space. However, potential adverse drug–drug interactions (DDIs), which may increase the risks for combination therapy, cannot be detected by existing computational synergy prediction methods. We propose DEML, an ensemble-based multi-task neural network, for the simultaneous optimization of five synergy regression prediction tasks, synergy classification, and DDI classification tasks. DEML uses chemical and transcriptomics information as inputs. DEML adapts the novel hybrid ensemble layer structure to construct higher order representation using different perspectives. The task-specific fusion layer of DEML joins representations for each task using a gating mechanism. For the Loewe synergy prediction task, DEML overperforms the state-of-the-art synergy prediction method with an improvement of 7.8% and 13.2% for the root mean squared error and the R2 correlation coefficient. Owing to soft parameter sharing and ensemble learning, DEML alleviates the multi-task learning ‘seesaw effect’ problem and shows no performance loss on other tasks. DEML has a superior ability to predict drug pairs with high confidence and less adverse DDIs. DEML provides a promising way to guideline novel combination therapy strategies for cancer treatment.

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Section: Introductionmentioning

confidence: 99%