Random introduction of degradable linkages into functional vinyl polymers by radical ring-opening polymerization, tailored for soft tissue engineering

Computational Package for Copolymerization Reactivity Ratio Estimation: Improved Access to the Error-in-Variables-Model

“…Exhibit A presents an overview of recent literature [10][11][12][13] regarding the copolymerization of 2- Another important piece of information is the degree of parameter correlation, which can be evaluated according to the slope of the JCR. Parameter correlation is something that should be avoided as much as possible and can be minimized by using designed experiments.…”

“…Exhibit A presents an overview of recent literature [10][11][12][13] regarding the copolymerization of 2-methylene-1,3-dioxepane (MDO; monomer 1) and vinyl acetate (VAc; monomer 2) (see also Table 1; RR stands for reactivity ratio). This copolymer has gained considerable attention in the past decade, largely due to its degradable properties.…”

“…Therefore, to demonstrate the advantages of EVM, select data from the literature will be re-evaluated (properly) and comparisons will be conducted. In a recent study by Undin et al [11], experimental data from six distinct feed compositions were used to estimate reactivity ratios for the MDO/VAc copolymerization. These six (batch) runs were allowed to continue until conversion did not change and the final conversion and composition measurements were reported.…”

“…However, it has many shortcomings, including unequal weighting of experimental data and symmetry issues (i.e., calculation results depend on which monomer is selected as M 1 ). The data set presented in [11] is especially vulnerable to these shortcomings, largely due to the undesigned initial feed compositions (collection and use of undesigned data for parameter estimation also induce considerable correlation between the parameters, which is highly undesirable). As shown in Table 2, some of the data are obtained under fairly low M 1 comonomer feed fraction; these conditions tend to have the greatest influence on the slope of a line, which ultimately affects reactivity ratio estimates obtained using the F-R method [15].…”

“…Thus, values of r 1 and r 2 depend on which monomer is selected as M 1 . To demonstrate this point, the data collected by Undin et al [11] are evaluated with M 1 = MDO (which was performed incorrectly in the original work; see Figure 4a) and with M 1 = VAc (performed herein for the demonstration; see Figure 4b). …”