Random laser in biological tissues impregnated with a fluorescent anticancer drug

Lahoz, F.; Martı́n, I.R.; Urgellés, Marta; Marrero-Alonso, Jorge; Marín, Raquel; Saavedra, Carlos Javier; Boto, Alicia; Dı́az, Mario

doi:10.1088/1612-2011/12/4/045805

Cited by 63 publications

(46 citation statements)

References 20 publications

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“…[7,8] WGM lasers made of polymers of biological origin are of interest for biosensing. To date, various biolasers have been investigated using random cavity, [9][10][11][12][13] distributed feedback, [14][15][16] Fabry-Perot (F-P), [17][18][19] and WGM capillary tube. [20] Generally, current devices are large (>>100 µm) and mainly rely on a time was 10, 60, 90 min for BSA, pectin, cellulose spheres, respectively.…”

mentioning

confidence: 99%

Microsphere Solid‐State Biolasers

Caixeiro

Fernandes

et al. 2017

Advanced Optical Materials

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Biolasers obtained from biomaterials are attracting a wealth of interest for their potential as future biosensors with enhanced sensitivity, and advanced cell tracking. Here, miniature biolasers are reported, which are formed by bovine serum albumin (BSA) protein and biosourced polysaccharides derived from land plants such as cellulose and pectin. Using a green processing route aided by simple emulsions, solid-state microspheres with diameters of 15–100 µm are fabricated and utilized as whispering gallery mode lasers with thresholds of a few µJ mm–2 and quality factors of up to 3000. Furthermore, BSA microlasers are found to be compatible with cell growth and resistant to the aqueous environment of cell culture media. This environmentally friendly and biocompatible design shows promise for future implantable biosensing devices opening a path between laser science and medicine

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mentioning

confidence: 99%

Microsphere Solid‐State Biolasers

Caixeiro

Fernandes

et al. 2017

Advanced Optical Materials

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“…RLs were originally proposed23 by Letokhov in the late 1960’s, but their first unambiguous observation was only reported in 1994 by Lawandy and collaborators24. Over the last two decades, studies in RLs have grown fantastically, including investigations on a myriad of interdisciplinary systems, from cold-atoms RLs25 and biomaterials26 to speckle-free laser imaging27 and cancer diagnostic2829.…”

mentioning

confidence: 99%

Observation of Lévy distribution and replica symmetry breaking in random lasers from a single set of measurements

Gomes¹,

Raposo²,

Moura³

et al. 2016

Sci Rep

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Random lasers have been recently exploited as a photonic platform for studies of complex systems. This cross-disciplinary approach opened up new important avenues for the understanding of random-laser behavior, including Lévy-type distributions of strong intensity fluctuations and phase transitions to a photonic spin-glass phase. In this work, we employ the Nd:YBO random laser system to unveil, from a single set of measurements, the physical origin of the complex correspondence between the Lévy fluctuation regime and the replica-symmetry-breaking transition to the spin-glass phase. A novel unexpected finding is also reported: the trend to suppress the spin-glass behavior for high excitation pulse energies. The present description from first principles of this correspondence unfolds new possibilities to characterize other random lasers, such as random fiber lasers, nanolasers and small lasers, which include plasmonic-based, photonic-crystal and bio-derived nanodevices. The statistical nature of the emission provided by random lasers can also impact on their prominent use as sources for speckle-free laser imaging, which nowadays represents one of the most promising applications of random lasers, with expected progress even in cancer research.

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“…Random lasing occurs when light is trapped in the disordered media, in this case tissue, by multiple scattering forming closed-path optical resonators. Lasing has been achieved in Rhodamine-6G-impregnated human colon, kidney [46], and bovine heart tissue [154]; Rhodamine-800-infiltrated bone tissue [155,156]; and fluorescent anticancer-druginfiltrated rodent uterine tissues [157]. The typical output spectrum and spatial profile of random lasers are highly sensitive to the microstructure of the tissue.…”

Section: Fluorescent Protein and Organic Dye Lasersmentioning

confidence: 99%

“…The typical output spectrum and spatial profile of random lasers are highly sensitive to the microstructure of the tissue. Random laser emission from more heterogeneous, disorganized, cancerous tissue exhibited more spectral lines than healthy tissues of the same organ [46,157,158]. The sensitivity of laser output to scatterers was used to detect nanoscale deformations in bones [156] and stress responses of bovine pericardium [154].…”

Section: Fluorescent Protein and Organic Dye Lasersmentioning

confidence: 99%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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Random laser in biological tissues impregnated with a fluorescent anticancer drug

Cited by 63 publications

References 20 publications

Microsphere Solid‐State Biolasers

Microsphere Solid‐State Biolasers

Observation of Lévy distribution and replica symmetry breaking in random lasers from a single set of measurements

Toward biomaterial-based implantable photonic devices

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