It is commonly accepted that cavitation erosion proceeds by various mechanical damage processes in micro-and mesoscale. The question is if there are other modes of material damage under cavitation loadings: another mechanism of mass extraction from the surface layers of the solid. In this paper, considerations on the possibility of occurrence of nanoparticle and droplet detachment mechanism in the cavitation erosion process supplemented with preliminary experimental evidences supporting this thesis are presented. Analysis of the general background of the process is carried out.