Random Positional Variation Among the Skull, Mandible, and Cervical Spine With Treatment Progression During Head-and-Neck Radiotherapy

Ahn, Peter H.; Ahn, A.; Lee, C. Joe; Shen, Jin; Miller, Eirwen M.; Lukaj, Alex; Milan, E; Yaparpalvi, Ravindra; Kalnicki, Shalom; Garg, Madhur

doi:10.1016/j.ijrobp.2008.10.007

Cited by 56 publications

(36 citation statements)

References 22 publications

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“…The results were comparable to those reported in Ahn et al 25 For the magnitude of relative vertebral motions clinically observed from the five patients, the proposed penalty could successfully preserve rigidity of five cervical vertebral bodies during deformable alignment.…”

Section: Discussionsupporting

confidence: 85%

Distance‐preserving rigidity penalty on deformable image registration of multiple skeletal components in the neck

2013

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Purpose: This study aims at developing and testing a novel rigidity penalty suitable for the deformable registration of tightly located skeletal components in the head and neck from planning computed tomography (CT) and daily cone-beam CT (CBCT) scans of patients undergoing radiotherapy. Methods:The proposed rigidity penalty is designed to preserve intervoxel distances within each bony structure. This penalty was tested in the intensity-based B-spline deformable registration of five cervical vertebral bodies (C1-C5). The displacement vector fields (DVFs) from the registrations were compared to the DVFs generated by using rigid body motions of the cervical vertebrae, measured by the surface registration of vertebrae delineated on CT and CBCT images. Twenty five pairs of planning CT (reference) and treatment CBCTs (target) from five patients were aligned without and with the penalty. An existing penalty based on the orthonormality of the deformation gradient tensor was also tested and the effects of the penalties compared. Results: The mean magnitude of the maximum registration error with the proposed distancepreserving penalty was (0.86, 1.12, 1.33) mm compared to (2.11, 2.49, 2.46) without penalty and (1.53, 1.64, 1.64) with the existing orthonormality-based penalty. The improvement in the accuracy of the deformable image registration was also verified by comparing the Procrustes distance between the DVFs. With the proposed penalty, the average distance was 0.11 (σ 0.03 mm) which is smaller than 0.53 (0.1 mm) without penalty and 0.28 (0.04 mm) with the orthonormality-based penalty. Conclusions:The accuracy of aligning multiple bony elements was improved by using the proposed distance-preserving rigidity penalty. The voxel-based statistical analysis of the registration error shows that the proposed penalty improved the integrity of the DVFs within the vertebral bodies.

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Section: Discussionsupporting

confidence: 85%

Distance‐preserving rigidity penalty on deformable image registration of multiple skeletal components in the neck

2013

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“…Changes in patient anatomy (weight loss and tumor shrinkage), as well as positioning variability, were correlated with dosimetric endpoints. We previously reported results with the same patient set, quantifying the degree of variability in various portions of the head and neck, noting that the 95% confidence interval of uncertainty in the region of the mandible and lower neck is upwards of 7 mm in an unpredictable manner (7).…”

Section: Introductionmentioning

confidence: 99%

Adaptive Planning in Intensity-Modulated Radiation Therapy for Head and Neck Cancers: Single-Institution Experience and Clinical Implications

Ahn¹,

Chen²,

Ahn³

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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122

107

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“…To minimize the occurrence of deformations, various external patient fixation devices have been used. The amount of deformations emerging in the head-and-neck region for patients immobilized with commercially available Aquaplast masks has been previously described (1)(2)(3)(4). Up until 2008, at the German Cancer Research Center, patients undergoing RT for headand-neck cancer were immobilized with a customized fixation device composed of a scotch-cast mask and a vacuum mould.…”

Section: Introductionmentioning

confidence: 99%

Local Setup Errors in Image-Guided Radiotherapy for Head and Neck Cancer Patients Immobilized With a Custom-Made Device

Giske

Stoiber

Schwarz

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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Random Positional Variation Among the Skull, Mandible, and Cervical Spine With Treatment Progression During Head-and-Neck Radiotherapy

Cited by 56 publications

References 22 publications

Distance‐preserving rigidity penalty on deformable image registration of multiple skeletal components in the neck

Distance‐preserving rigidity penalty on deformable image registration of multiple skeletal components in the neck

Adaptive Planning in Intensity-Modulated Radiation Therapy for Head and Neck Cancers: Single-Institution Experience and Clinical Implications

Local Setup Errors in Image-Guided Radiotherapy for Head and Neck Cancer Patients Immobilized With a Custom-Made Device

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