Random Protein-Creatinine Ratio for the Quantitation of Proteinuria in Pregnancy

Abstract

In nonambulatory hypertensive pregnant patients, there is a strong correlation between random voided protein-creatinine ratios and 24-hour urine protein excretions.

Random urine protein to creatinine ratio as a diagnostic method of significant proteinuria in pre‐eclampsia

“…Consistent with previous studies, [2][3][4][5][6][7][8][9][10][11] our data demonstrated a strong correlation between the two methods in pregnant women suspected of having pre-eclampsia. It suggests that the random urinary p:c ratio is an accurate test for discriminating between significant and insignificant proteinuria.…”

“…The urine p:c ratio would, also, be assessable in all trimesters of pregnancy. 2 The association of gestational age with p:c ratio and 24-h proteinuria is not significant. 4,5 These points prompted our investigation into the use of a single-voided urine p:c ratio to estimate quantitative proteinuria.…”

“…The dipstick is a quick and simple test, but it has been shown to be inaccurate with a reported sensitivity of only 44% in one study. 2 Single-voided p:c ratio is hypothesised to be preferable to random spot urine protein because the ratio of two stable excretion rates (creatinine and protein) would cancel out the time factor and thus provide a better estimation of 24-h protein excretion. 3 Moreover, a single urine p:c ratio is very accurate; and it is not necessary to repeat it.…”

“…Several studies have suggested an acceptable correlation between single-voided p:c ratio and 24-h urine protein in pregnant patients. [2][3][4][5][6][7][8][9][10][11] Nevertheless, the results reported may be limited by examining patients with a different underling disease in one study 11 and not having a large enough sample in another one. 10 Some studies were conducted on hospitalised pregnant patients with suspected pre-eclampsia, whose results may not be applicable for outpatient pregnant women.…”

The Utility of 12-Hour Urine Collection for the Diagnosis of Preeclampsia

“…2 Several studies have investigated urine protein-to-creatinine ratio as a rapid test to obviate the need for a 24-hour urine collection. [3][4][5][6][7][8][9][10][11][12] Although the data show that extremely high or low urine protein-to-creatinine ratio values may be a substitute for a 24-hour urine collection, 6,13 there are clinical circumstances that may still require a 24-hour urine collection.…”