Randomised clinical trial: a Lactobacillus <scp>GG</scp> and micronutrient‐containing mixture is effective in reducing nosocomial infections in children, vs. placebo

Bruzzese, Eugenia; Fedele, Maria Cristina; Bruzzese, Dario; Viscovo, Sara; Giannattasio, Antonietta; Mandato, Claudia; Siani, Paolo; Guarino, Alfredo

doi:10.1111/apt.13740

Cited by 28 publications

(23 citation statements)

References 31 publications

(63 reference statements)

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“…Prevention of HAI is one of the top priorities of the Center of Diseases Control and Prevention (CDC), but preventive concepts so far did not addressed the potential contribution of the gut microbiota of hospitalized patients to HAI. Interestingly, a recent study showed that in a randomized, double-blind, placebo-controlled trial in hospitalized children, an intake of a mixture containing Lactobacillus GG and micronutrients reduced the incidence of HAI, supporting the hypothesis that certain manipulations of the intestinal microbiota may provide a safeguarding strategy to prevent such infections 15 .…”

Section: Discussionmentioning

confidence: 95%

“…As hospitalized patients are at increased risk for acquiring HAIs, identifying the dysbiosis associated with this population can serve as a first step toward specific therapeutic interventions in this population. In support of this concept is a recent study that showed that a mixture containing Lactobacillus GG and micronutrients reduced the incidence of HAI 15 .…”

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Fecal microbial characterization of hospitalized patients with suspected infectious diarrhea shows significant dysbiosis

Braun

Segni

BenShoshan

et al. 2017

Sci Rep

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Hospitalized patients are at increased risk for acquiring healthcare-associated infections (HAIs) and inadequate nutrition. The human intestinal microbiota plays vital functions in nutrient supply and protection from pathogens, yet characterization of the microbiota of hospitalized patients is lacking. We used 16S rRNA amplicon sequencing to characterize the global pattern of microbial composition of fecal samples from 196 hospitalized patients with suspected infectious diarrhea in comparison to healthy, non-hospitalized subjects (n = 881), and to traditional culture results. We show that hospitalized patients have a significant rise in α-diversity (richness within sample) from birth to <4 years of age, which continues up to the second decade of life. Additionally, we noted a profoundly significant increase in taxa from Proteobacteria phylum in comparison to healthy subjects. Finally, although more than 60% of hospitalized samples had a greater than 10% abundance of Proteobacteria, there were only 19/196 (10%) positive cultures for Campylobacter, Salmonella, or Shigella entero-pathogens in traditional culturing methods. As hospitalized patients have increased risk for HAIs and inadequate nutrition, our data support the consideration of nutritional and/or microbial modification in this population.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 90%

Fecal microbial characterization of hospitalized patients with suspected infectious diarrhea shows significant dysbiosis

Braun

Segni

BenShoshan

et al. 2017

Sci Rep

View full text Add to dashboard Cite

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“…Another study with L. rhamnosus GG was performed in 90 hospitalized children, and they received L. rhamnosus GG plus vitamin B, vitamin C, and zinc or placebo. The consumption of a combination of L. rhamnosus GG and micronutrients was effective in reducing the incidence of gastrointestinal infections and the length of hospitalization compared to placebo [ 43 ]. Furthermore, the duration and severity of symptoms were reduced [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Immune-Mediated Mechanisms of Action of Probiotics and Synbiotics in Treating Pediatric Intestinal Diseases

et al. 2018

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The pediatric population is continually at risk of developing infectious and inflammatory diseases. The treatment for infections, particularly gastrointestinal conditions, focuses on oral or intravenous rehydration, nutritional support and, in certain case, antibiotics. Over the past decade, the probiotics and synbiotics administration for the prevention and treatment of different acute and chronic infectious diseases has dramatically increased. Probiotic microorganisms are primarily used as treatments because they can stimulate changes in the intestinal microbial ecosystem and improve the immunological status of the host. The beneficial impact of probiotics is mediated by different mechanisms. These mechanisms include the probiotics’ capacity to increase the intestinal barrier function, to prevent bacterial transferation and to modulate inflammation through immune receptor cascade signaling, as well as their ability to regulate the expression of selected host intestinal genes. Nevertheless, with respect to pediatric intestinal diseases, information pertaining to these key mechanisms of action is scarce, particularly for immune-mediated mechanisms of action. In the present work, we review the biochemical and molecular mechanisms of action of probiotics and synbiotics that affect the immune system.

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“…Einen völlig anderen Stellenwert hat das lokal wirksame Antibiotikum Rifaximin. Es wirkt vor allem auf die darmständige Mikrobiota und wird nur zu 1 % systemisch resorbiert [106] [112,113]. Jedoch liegen dazu bislang widersprüchliche Ergebnisse vor.…”

Section: Antibiotikaunclassified

Mikrobiota und Reizdarmsyndrom – eine kritische Bestandsaufnahme

Enck

Mazurak

2019

Z Gastroenterol

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ZusammenfassungDieses narrative Review beleuchtet kritisch die Rolle der Darmmikrobiota bei funktionellen Störungen vom Typ Reizdarmsyndrom. Ausgehend von Veränderungen der Zusammensetzung und Vielfalt der Mikrobiota, wie sie oft in korrelativen Studien gefunden wurden, stellt es kritische Fragen nach Ursache/Wirkung, nach Spezifität und Sensitivität der Befunde im Vergleich zu anderen Erkrankungen und nach den klinisch-wissenschaftlichen Möglichkeiten, die Mikrobiota zu verändern. Dabei werden Prä-, Pro- und Antibiotika ebenso diskutiert wie der Einfluss von Ernährung und der Austausch durch fäkalen Mikrobiom-Transfer (FMT). Für das Reizdarmsyndrom haben sich bislang die wenigsten Strategien als erfolgreiche Therapieansätze erwiesen. Dies kann zum einen an der Heterogenität des Krankheitsbildes selbst liegen, zum anderen an nach wie vor unklaren Konzepten der mikrobiellen Forschung, z. B. dem Begriff der Dysbiose, oder an methodischen Differenzen der molekulargenetischen Forschung, die in den publizierten Arbeiten nicht sichtbar werden. Künftige Studien sollten sich auf die Identifizierung der Faktoren konzentrieren, die das Ansprechen auf solche Behandlungsarten erklären und vorhersagen können.

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Randomised clinical trial: a Lactobacillus GG and micronutrient‐containing mixture is effective in reducing nosocomial infections in children, vs. placebo

Abstract: A mixture containing Lactobacillus GG and micronutrients may reduce the incidence of nosocomial infections, supporting the hypothesis that this may represent a valid strategy to prevent nosocomial infections.

Cited by 28 publications

References 31 publications

Fecal microbial characterization of hospitalized patients with suspected infectious diarrhea shows significant dysbiosis

Fecal microbial characterization of hospitalized patients with suspected infectious diarrhea shows significant dysbiosis

Immune-Mediated Mechanisms of Action of Probiotics and Synbiotics in Treating Pediatric Intestinal Diseases

Mikrobiota und Reizdarmsyndrom – eine kritische Bestandsaufnahme

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