Randomised clinical trial investigating the effects of combined administration of octreotide and methylglucamine diatrizoate in the older persons with adhesive small bowel obstruction

Zhang, Y.; Gao, Yang; Ma, Qingyong; Dang, Chengxue; Wei, Wensheng; Antoni, F. De; Rocci, R; Chen, W.

doi:10.1016/j.dld.2005.10.010

Cited by 19 publications

(21 citation statements)

References 47 publications

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“…Adhesions have been well documented as the leading cause of intestinal obstruction, especially in the old patients with a history of previous abdominal surgery [2]. Between 49 % and 74 % of small bowel obstructions are caused by intraabdominal adhesions [3].…”

Section: Introductionmentioning

confidence: 99%

Prospective Evaluation of Oral Gastrografin® in the Management of Postoperative Adhesive Small Bowel Obstruction

et al. 2012

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Oral Gastrografin®, a hyperosmolar water-soluble contrast medium, may have a therapeutic effect in adhesive small bowel obstruction. However, findings are still conflicting, as some authors did not find a therapeutic advantage. So, this prospective, randomized, and clinical trial study was designed to determine the value of Gastrografin in adhesive small bowel obstruction. The primary end points were the evaluation of the operative rate reduction and shortening the hospital stay after the use of Gastrografin. A total of 84 patients were randomized into two groups: the control group received conventional treatment, whereas the study group received in addition of 100 mL Gastrografin meal. Patients were followed up within 4 days after admission, and clinical and radiological (if needed) improvements were evaluated. Although the results showed that Gastrografin can decrease

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Section: Introductionmentioning

confidence: 99%

Prospective Evaluation of Oral Gastrografin® in the Management of Postoperative Adhesive Small Bowel Obstruction

et al. 2012

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“…Among the remaining articles, 116 were excluded by title/abstract review on the basis of their selection criteria and PICO. The remaining 17 articles were screened by full‐text review, after which 12 studies including a total of 1153 patients with PSBO were regarded as suitable for inclusion in the data synthesis . The selection process for exclusion is shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…Our analysis did not include any study that had used Urografin as WSCM for treatment of patients with PSBO. In fact, among the 12 RCT, three clearly indicated the usefulness of Gastrografin for treatment of PSBO . Furthermore, none of the analyzed RCT clearly contraindicated Gastrografin for treatment of such patients.…”

Section: Discussionmentioning

confidence: 97%

Gastrografin reduces the need for additional surgery in postoperative small bowel obstruction patients without long tube insertion: A meta‐analysis

Ishizuka

Shibuya

Takagi

et al. 2018

Annals of Gastroent Surgery

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Background Small bowel obstruction (SBO) is a well‐known major postoperative complication requiring immediate diagnosis and treatment to avoid additional invasive surgical procedures. Water‐soluble contrast medium is often given not only for diagnosis but also for treatment. Although numerous studies have investigated the significance of this treatment, no consensus has yet been established regarding its indications and efficacy. Objective To explore whether Gastrografin can reduce the need for additional surgery in patients with postoperative SBO (PSBO). Methods We carried out a comprehensive electronic search of the literature (Cochrane Library, MEDLINE, PubMed and the Web of Science) up to February 2017 to identify studies that had shown efficacy of Gastrografin in reducing the need for surgery in patients with PSBO. To integrate the individual effects of Gastrografin, a meta‐analysis was done using random‐effects models to calculate the risk ratio (RR) and 95% confidence interval (CI), and heterogeneity was analyzed using I2 statistics. Results Twelve studies involving a total of 1153 patients diagnosed as having PSBO were included in this meta‐analysis. Not all patients received long‐tube insertion. Among 580 patients who received Gastrografin, 100 (17.2%) underwent surgery, whereas among 573 patients who did not receive Gastrografin, 143 (25.0%) underwent surgery. Giving Gastrografin significantly reduced the need for surgery (RR, 0.66; 95% CI, 0.46‐0.95; P = 0.02; I2 = 52%) in comparison with patients who did not receive Gastrografin. Conclusion Results of this meta‐analysis show that giving Gastrografin reduces the need for surgery in PSBO patients without long‐tube insertion.

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“…Abdominal adhesions can begin forming within several hours postoperatively and are responsible for 60 to 70 % of all small intestinal obstructions [8,9]. This is especially evident in patients with a history of previous abdominal surgery [10], while other causes of adhesion account for few cases [11]. The presence of adhesions adds a mean 24 min to the surgical duration, increases the risk of iatrogenic intestinal injury, and makes future laparoscopic surgery more difficult or even impossible [12,13].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Plain and Contrast Radiography, and Multi-slice Computed Tomography in Diagnosing Intestinal Obstruction in Different Locations

Liu

Sun

2015

Indian J Surg

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Early intestinal obstruction is easily misdiagnosed. Many physicians consider terminal bouton if computed tomography (CT) scan is done. However, different examinations provide diverse information and significance. This retrospective, randomized, clinical study investigated the diagnostic value of three imaging modalities for intestinal obstruction, supine and upright (or decubitus) plain abdominal radiography, contrast radiography using Gastrografin, and 64 multi-slice spiral CT (MSCT). A total 142 patients with intestinal obstruction were examined. The diagnostic accuracy of plain radiography, contrast radiography, and MSCT for detecting small bowel obstruction was 62.5, 85, and 77.5 %, for localizing the obstruction was 0, 90, and 78.75 %, and for determining the cause of obstruction was 0, 71, and 65 %, respectively. The diagnostic accuracy for detecting large bowel obstruction was 53.23, 73.17, and 92 %, and for localizing the obstruction was 38.17, 60.98, and 98 %, respectively. The diagnostic accuracy of MSCT in determining the cause of obstruction was 91 %. None of the patients administered Gastrografin experienced any adverse effects. In conclusion, MSCT has great diagnostic value in identifying the site and cause of intestinal obstruction, especially in cases of large bowel obstruction. Contrast radiography using Gastrografin was effective in diagnosing and treating small bowel obstruction, making it a beneficial adjunct to MSCT.

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Randomised clinical trial investigating the effects of combined administration of octreotide and methylglucamine diatrizoate in the older persons with adhesive small bowel obstruction

Cited by 19 publications

References 47 publications

Prospective Evaluation of Oral Gastrografin® in the Management of Postoperative Adhesive Small Bowel Obstruction

Prospective Evaluation of Oral Gastrografin® in the Management of Postoperative Adhesive Small Bowel Obstruction

Gastrografin reduces the need for additional surgery in postoperative small bowel obstruction patients without long tube insertion: A meta‐analysis

Diagnostic Value of Plain and Contrast Radiography, and Multi-slice Computed Tomography in Diagnosing Intestinal Obstruction in Different Locations

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