Randomised clinical trial: Tong‐Xie‐Yao‐Fang granules versus placebo for patients with diarrhoea‐predominant irritable bowel syndrome

Chen, M.; Tang, Tai-Chun; Wang, Y.; Shui, Jiacheng; Xiao, Xianjun; Xiao, Lan; Yu, Penglong; Zhang, C.; Wang, S.‐H.; Yao, Jing; Zheng, Hui; Huang, Demei

doi:10.1111/apt.14817

Cited by 50 publications

(68 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TXYF also yielded improvements in several secondary outcomes including abdominal pain, bloating, stool frequency and consistency. Interestingly, TXYF treatment benefits persisted several weeks beyond the active treatment period . A calculated number‐needed‐to‐treat (NNT) of 5 for adequate relief using TXYF compared favourably to contemporary medications approved for IBS‐D, such as eluxadoline (NNT = 12.5) and rifaximin (NNT = 10.4) .…”

mentioning

confidence: 65%

“…In a recent issue of AP&T , Chen and colleagues convincingly demonstrated Tong‐Xie‐Yao‐Fang (TXYF) to be effective in reducing the global symptoms of diarrhoea‐predominant irritable bowel syndrome (IBS‐D) . Perhaps unfamiliar to the allopathic physician, the traditional Chinese Medicine (TCM) herbal preparation TXYF has been used for hundreds of years as a remedy, not for IBS, but rather “liver stagnation and spleen deficiency”.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Editorial: Tong‐Xie‐Yao‐Fang (TXYF) for irritable bowel syndrome with diarrhoea (IBS‐D)—ancient medicine meets modern study

Vitta

Sayuk

2018

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 65%

mentioning

confidence: 99%

Editorial: Tong‐Xie‐Yao‐Fang (TXYF) for irritable bowel syndrome with diarrhoea (IBS‐D)—ancient medicine meets modern study

Vitta

Sayuk

2018

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…Chen et al, conducted a double-blind placebo-controlled randomized trial to study the efficacy of TXYF for treating IBS-D. The study concluded that use of TXFY was superior to placebo in controlling symptoms of IBS-D with low adverse event rate [20].…”

Section: Bodymentioning

confidence: 99%

Using Traditional Chinese Medicine for Irritable Bowel Syndrome

Ryu¹

2018

ACIM

View full text Add to dashboard Cite

In recent years, Traditional Chinese Medicine (TCM) has gained popularity in the Western Hemisphere. More people are utilizing TCM as a conservative treatment option prior to proceeding with more invasive options such as pharmaceuticals and surgeries. Acupuncture and Chinese herbal medicine are the most well-known modalities of TCM. They are commonly used to treat disorders of various systems including digestive disorders. This article will discuss how TCM is used to treat Irritable Bowel Syndrome (IBS) by looking at numbers of research studies. Symptoms of IBS include abdominal pain, bloating, cramping and changes in bowel habits such as diarrhea and constipation. The studies show the efficacy and safety of using TCM to treat patients with IBS without significant adverse effects. Acupuncture and Chinese herbal medicine help decrease symptoms of IBS by facilitating and enhancing the functions of digestive organs, regulating bowel habits, assisting in release of hormones and neurotransmitters, reducing abdominal pain and bloating and stabilizing stress and anxiety that can contribute to IBS. Therefore, acupuncture and Chinese herbal medicine is recommended being a part of the treatment plan for those suffering from IBS.

show abstract

“…Rhizoma Atractylodis Macrocephalae and Citri Reticulatae Pericarpium strengthen spleen to eliminate dampness while Paeoniae Radix Alba and Saposhnikoviae Radix soothe liver to regulate qi. These four herbs contained in TXYF by orchestrating the function of spleen and liver to relieve symptoms of IBS-D. A recent study has proved that TXYF is e cacious in the relief of abdominal pain and bloating in IBS-D patients with only sporadic adverse events (9). But there is a scrap of contradictory evidence that TXYF has little impact on the amelioration of symptoms of IBS-D (10).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Tong-Xie-Yao-Fang granule and its impact on whole transcriptome profiling in diarrhea-predominant irritable bowel syndrome patients: study protocol for a randomized controlled trial

Wang

Huang

Zhu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Irritable bowel syndrome (IBS) is one kind of common functional bowel disease with obscure pathogenesis and exploration about whole transcriptome profiling in IBS-D is still negligible. Conventional medications have limited effects, which makes focus shifted to traditional Chinese medicine (TCM). Tong-Xie-Yao-Fang, as a classic herbal formula in TCM, is pretty effective and safe for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D), but the underlying therapeutic mechanism remains unknown. We aim to verify the efficacy and safety of TXYF granule (the formula particles mixed together) in IBS-D and elucidate the gene-level mechanism of IBS-D and therapeutic targets of TXYF granule based on whole transcriptome analysis. Methods/design: This is a randomized, double-blind and placebo-controlled clinical trial consisting of 2 weeks run-in period, 12 weeks treatment period and 8 weeks follow-up period. We will enroll 120 participants with IBS-D, who will be randomly assigned to TXYF granule group and the placebo group and recruit additional 10 healthy individuals as controls for mechanistic outcome. The two groups respectively take TXYF granule or placebo orally for treatment. The primary outcome is the response rate of IBS-Symptom Severity Score (IBS-SSS). The secondary outcomes include adequate relief (AR), IBS-Quality of Life Questionnaire (IBS-QOL) and long-term efficacy. Mechanistic outcome is the whole transcriptome profiling of the intestinal mucosae from IBS participants before and after the treatment and healthy individuals. Discussion: This trial will prove the effectiveness and safety of TXYF granule with high-quality evidence and provide a penetrating and comprehensive perspective on the molecular mechanism of IBS-D by whole transcriptome analysis, which makes us pinpoint specific biomarkers of IBS-D and therapeutic targets of TXYF.

show abstract

Randomised clinical trial: Tong‐Xie‐Yao‐Fang granules versus placebo for patients with diarrhoea‐predominant irritable bowel syndrome

Abstract: During a 4 week trial, TXFY granules were superior to placebo in controlling symptoms of IBS-D.

Cited by 50 publications

References 28 publications

Editorial: Tong‐Xie‐Yao‐Fang (TXYF) for irritable bowel syndrome with diarrhoea (IBS‐D)—ancient medicine meets modern study

Editorial: Tong‐Xie‐Yao‐Fang (TXYF) for irritable bowel syndrome with diarrhoea (IBS‐D)—ancient medicine meets modern study

Using Traditional Chinese Medicine for Irritable Bowel Syndrome

Efficacy of Tong-Xie-Yao-Fang granule and its impact on whole transcriptome profiling in diarrhea-predominant irritable bowel syndrome patients: study protocol for a randomized controlled trial

Contact Info

Product

Resources

About