Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration

Olsen, S F; Sørensen, Jacob Thorsted; Secher, Niels Jørgen; Hedegaard, Morten; Henriksen, Tine Brink; Hansen, Harald S.; Grant, Adrian

doi:10.1016/0140-6736(92)90533-9

Cited by 432 publications

(87 citation statements)

References 14 publications

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“…Compared with the ordinary egg group, a significant increase in the gestation length of 6.0 ± 2.3 d (P = 0.009) and a nonsignificant difference of 83 ± 62 g (P = 0.184) were observed in the high-DHA egg group, after adjustment for confounders. Furthermore, two double-blind randomized experimental trials with fish oil conducted among pregnant women showed positive and significant relationships between supplementation with n-3 HUFA and GA as well as birth weight (26,27). However, Olsen et al (27) did not observe, in comparison with a placebo group, significant effects of n-3 HUFA on GA and birth weight in women with any of the following gestational conditions: twin pregnancy, preeclampsia, or intrauterine growth retardation.…”

Section: Discussionmentioning

confidence: 95%

“…Marine n-3 HUFA also have been associated with increased birth weight and longer GA (17,(19)(20)(21)(22)(23)(24)(25). Results from two double-blind randomized trials have shown that the gestational duration and birth weight could be improved with fish oil supplementation during pregnancy as compared with a placebo group (26,27). In a recent case-control study, the risk of premature delivery and LBW was reported as 3.6 times higher among women who did not eat any fish during pregnancy compared with a group whose mean intake of marine products was 44 g per day (18).…”

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confidence: 93%

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Gestational age and birth weight in relation to n−3 fatty acids among inuit (Canada)

Lucas

Dewailly

Muckle

et al. 2004

Lipids

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Seafood consumption during pregnancy carries both benefits (high n-3 FA intake) and risks (exposure to environmental contaminants) for the developing fetus. We determined the impacts of marine n-3 FA and environmental contaminants on gestational age (GA) of Nunavik women and the anthropometric characteristics of their newborns. FA and contaminant (polychlorinated biphenyls and mercury) concentrations were measured in cord plasma of Nunavik newborns (n = 454) and compared with those of a group of newborns (n = 29) from southern Québec. Data were collected from hospital records and birth certificates. In Nunavik newborns, arachidonic acid (AA) was two times lower (P < 0.0001), whereas DHA concentration, the sigman-3 / sigman-6 ratio, and the percentage of n-3 highly unsaturated FA (HUFA) (of the total HUFA) were three times higher (P < 0.0001) compared with southern Québec newborns. After controlling for confounders, GA and birth weight were higher by 5.4 d [95% confidence interval (CI): 0.7-10.1] and 77 g (95% CI: -64 to 217) in the third tertile of percentage of n-3 HUFA (of the total HUFA) as compared with the first tertile. There was no evidence that contaminants had negative effects on GA or birth weight. In this seafood-eating population, an increase in the proportion of n-3 HUFA (of the total HUFA), measured in umbilical cord plasma phospholipids, was associated with a significantly longer GA.

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Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 93%

Gestational age and birth weight in relation to n−3 fatty acids among inuit (Canada)

Lucas

Dewailly

Muckle

et al. 2004

Lipids

View full text Add to dashboard Cite

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“…We examine the risk of preterm delivery in women with zero fish intake during a prolonged period of pregnancy; this question could not be addressed with data from any of the three other cohorts mentioned [21,23,24]. Finally, we examine if seafood intake is associated with increased risk of elective and postterm delivery; this possibility has been suggested by some earlier trials with fish oil [8,9].…”

Section: Introductionmentioning

confidence: 96%

“…The hypothesis has been supported by some [8][9][10] but not all [11][12][13][14] randomised controlled trials [15], and by some [16,17] but, again, far from all [18][19][20][21][22][23][24] observational studies.…”

Section: Introductionmentioning

confidence: 99%

Duration of pregnancy in relation to seafood intake during early and mid pregnancy: prospective cohort

et al. 2006

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We examined the association between exposure to seafood intake during two periods of pregnancy on the one hand and risks of preterm delivery and postterm delivery on the other. In a prospective cohort of 8729 pregnant Danish women, we assessed frequency of fish meals during the first and second trimester of pregnancy by questionnaires completed around gestation weeks 16 and 30, respectively. When fish intake was based solely on intake reported for the early period of pregnancy, mean gestation length was shorter by 3.91 (95% CI: 2.24-5.58) days and odds of preterm delivery were increased 2.38 (1.23-4.61) times in those who never consumed fish (n = 308) vs. those who consumed both fish as main meal and fish in sandwiches at least once per week (n = 785). These measures were similar when fish intake was based solely on intake reported for mid-pregnancy. In the subgroup of women reporting same intake in the two trimesters, those who never consumed fish (n = 165) had 8.57 (5.46-11.7) days shorter mean gestation and 19.6 (2.32-165) times increased odds of preterm delivery, compared to high fish consumers (n = 127); odds of elective and postterm delivery were reduced by a factor 0.33 (0.11-1.02) and 0.34 (0.12-0.95), respectively, in zero fish consumers. All analyses were adjusted for potential confounding by factors such as maternal smoking, height, and prepregnant weight. We conclude that never consuming fish in the first two trimesters of pregnancy was an extremely strong risk factor for preterm delivery but was also associated with reduced risks of elective delivery and postterm delivery.

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“…Fish oil supplements given to women from week 30 of pregnancy extended gestation an average of 4 days in Danish women compared with women receiving olive oil supplements [21]. Low consumption of seafood has been associated with premature delivery [22].…”

Section: Human Studiesmentioning

confidence: 99%

Nutrients, neurodevelopment, and mood

Casper

2004

Curr Psychiatry Rep

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Human neurodevelopment is the result of genetic and environmental interactions. This paper examines the role of prenatal nutrition relative to psychiatric disorders and explores the relationship among nutrients, mood changes, and mood disorders. Epidemiologic studies have found that adults who were born with a normal, yet low birth weight have an increased susceptibility to diseases such as coronary heart disease, diabetes, and stroke in adulthood. Prenatal caloric malnutrition, low birth weight, and prematurity also increase the risk for neurodevelopmental disorders, schizophrenia, affective disorders, and schizoid and antisocial personality disorders. Placebo-controlled studies in medicated patients suggest that add-on treatment with omega-3 fatty acids, particularly eicosapentaenoic acid, may ameliorate symptoms of major depressive disorder. Additional studies are necessary to confirm any benefits for bipolar disorders.

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Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration

Cited by 432 publications

References 14 publications

Gestational age and birth weight in relation to n−3 fatty acids among inuit (Canada)

Gestational age and birth weight in relation to n−3 fatty acids among inuit (Canada)

Duration of pregnancy in relation to seafood intake during early and mid pregnancy: prospective cohort

Nutrients, neurodevelopment, and mood

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