Randomised controlled trials for the prevention of cognitive decline or dementia: A systematic review

Coley, Nicola; Giulioli, Caroline; Aisen, Paul S.; Vellas, Bruno; Andrieu, Sandrine

doi:10.1016/j.arr.2022.101777

Cited by 30 publications

(24 citation statements)

References 148 publications

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“…Unfortunately, though there have only been a few large-scale and well-powered trials on this topic to date, a recent review found that most trials have found unsuccessful results in the primary outcome. 4 It is worth asking ourselves what is behind the association between a healthy lifestyle and cognitive aging in older adults. How should we interpret the results found in observational studies?…”

Section: Healthy Lifestyle and Cognitive Aging: What Is The Gap Behin...mentioning

confidence: 99%

Healthy lifestyle and cognitive aging: What is the gap behind prescribing healthier lifestyle?

Aravena

2023

Alzheimer's & Dementia

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Although there is a clear link between lifestyle and cognitive health, the dissonance between observational and intervention studies results reveals gaps in the knowledge of how to translate healthy lifestyles into better cognitive health for the population. This letter discusses gaps in interpreting observational studies linking healthy lifestyles and cognitive health in older adults. The main goal is to briefly highlight the necessity of understanding and incorporating intrinsic and extrinsic drivers of engagement in healthy lifestyles before prescribing and implementing individual and multicomponent programs.

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Section: Healthy Lifestyle and Cognitive Aging: What Is The Gap Behin...mentioning

confidence: 99%

Healthy lifestyle and cognitive aging: What is the gap behind prescribing healthier lifestyle?

Aravena

2023

Alzheimer's & Dementia

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show abstract

“…3 Furthermore, genetic determinants and lifestyle interventions should be considered for evaluating the progression of cognitive decline. 4 In conclusion, factors other than baseline metrics may also contribute to the progression of cognitive decline in older adults.…”

mentioning

confidence: 94%

Reader Response: Predicting Cognitive Decline in Older Adults Using Baseline Metrics of AD Pathologies, Cerebrovascular Disease, and Neurodegeneration

Kawada¹

2023

Neurology

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“…considered for evaluating the progression of cognitive decline. 4 In conclusion, factors other than baseline metrics may also contribute to the progression of cognitive decline in older adults.…”

mentioning

confidence: 94%

Author Response: Predicting Cognitive Decline in Older Adults Using Baseline Metrics of AD Pathologies, Cerebrovascular Disease, and Neurodegeneration

Prosser¹

2023

Neurology

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Randomised controlled trials for the prevention of cognitive decline or dementia: A systematic review

Cited by 30 publications

References 148 publications

Healthy lifestyle and cognitive aging: What is the gap behind prescribing healthier lifestyle?

Healthy lifestyle and cognitive aging: What is the gap behind prescribing healthier lifestyle?

Reader Response: Predicting Cognitive Decline in Older Adults Using Baseline Metrics of AD Pathologies, Cerebrovascular Disease, and Neurodegeneration

Author Response: Predicting Cognitive Decline in Older Adults Using Baseline Metrics of AD Pathologies, Cerebrovascular Disease, and Neurodegeneration

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