Randomized clinical study of Gastrografin® administration in patients with adhesive small bowel obstruction (<i>Br J Surg</i> 2003; 90: 542-546)

Chintamani, Radhika

doi:10.1002/bjs.4377

Cited by 1 publication

(2 citation statements)

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“…GG and Urografin (Bayer Australia Ltd.) were the most common agents used in these radiological procedures [ 13 ]. Aside from its routine use in radiology, GG has been safely employed orally in patients with small bowel obstruction and assessed as a prokinetic in prolonged postoperative ileus [ 14 , 15 ].…”

Section: Methodsmentioning

confidence: 99%

“…Aside from its routine use in radiology, GG has been safely employed orally in patients with small bowel obstruction and assessed as a prokinetic in prolonged post-operative ileus. [14,15] Gastrografin Measurement by DECT Dual emission CT scanning (DECT) is a new technology that allows acquisition of 2 datasets from the same anatomical region at different voltages. [16] In contrast to single-spectrum imaging, which depicts the organs based on spatial distribution of the object attenuation, DECT is sensitive to the chemical composition.…”

Section: A R T I C L Ementioning

confidence: 99%

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A development study of drain fluid gastrografin as a biomarker of anastomotic leak

et al. 2022

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Anastomotic leakage is the anathema of colorectal surgery. Its occurrence leads to increased morbidity and mortality and a prolonged hospital stay. Much work has gone into studying various biomarkers in drain fluid to facilitate early detection of anastomotic leak (AL). This 2a development study aims to assess the safety and feasibility of reliably detecting the iodine in Gastrografin (GG) in drain fluid and stool samples by Dual-Energy Computed Tomography (DECT). Methods This is a prospective, observational, controlled, consecutive cohort study establishing the safety and feasibility of the detection of GG in surgical drain fluid and stool as a biomarker of anastomotic leak when patients with a low pelvic colorectal anastomosis undergo luminal flushing of the rectal tube with GG. Results Ten consecutive patients were allocated to the saline flush group and the following ten to the GG flush group. Three patients in the saline flush group developed an AL. One patient in the GG flush group developed an AL. An elevation in the drain fluid GG was detected using DECT on the day of clinical deterioration. None of the patients in the control group were found to have a positive result on DECT. Conclusions This observational 2a development study demonstrates the safety of a novel approach to the early detection of AL from extraperitoneal colorectal anastomoses. The technique requires validation in a larger cohort and a multicentre study is planned to investigate the efficacy of GG rectal tube flushes as an early biomarker of AL in low pelvic anastomoses. What does this paper add to the literature? This paper assesses rectally administered Gastrografin (GG) as a novel drain fluid biomarker of anastomotic leak (AL). Few studies have investigated the extravasation of intraluminal substances. Intuitively, these are more likely to lead to the diagnosis of AL verses those that simply predict the possibility of a leak.

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Section: Methodsmentioning

confidence: 99%

Section: A R T I C L Ementioning

confidence: 99%

A development study of drain fluid gastrografin as a biomarker of anastomotic leak

et al. 2022

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Randomized clinical study of Gastrografin® administration in patients with adhesive small bowel obstruction (Br J Surg 2003; 90: 542-546)

Abstract: A short synthesis of the enantiomer of the title compound relies on Lewis acid promoted tandem oxa‐ and carbacyclizations (see scheme). This demonstration of tandem cyclizations provides experimental support for the chemical viability of a proposed biogenetic pathway.

Cited by 1 publication

References 6 publications

A development study of drain fluid gastrografin as a biomarker of anastomotic leak

A development study of drain fluid gastrografin as a biomarker of anastomotic leak

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