Randomized clinical trial and economic analysis of four-layer compression bandaging for venous ulcers (<i>Br J Surg</i> 2003; 90: 794-798)

Enoch, Stuart; Williams, Dean T.; Price, Patricia Elaine; Harding, Peter

doi:10.1002/bjs.4424

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…On the other hand, another study, which included 200 patients with ulceration of venous etiology, compared the effectiveness of 4-layer compression therapy and elastic bandages. 56 The final analysis demonstrated that 4-layer compression was more effective. Customized compression and pressure degree significantly improve the conditions existing in venous circulation and microcirculation, if applied constantly.…”

Section: Discussionmentioning

confidence: 96%

The role of compression therapy in the treatment of venous leg ulcers

Mościcka¹,

Szewczyk²,

Cwajda‐Białasik³

et al. 2018

Adv Clin Exp Med

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Epidemiological data regarding venous leg ulcers, specifically low healing rates and frequent recurrences (occurring in 20-70% of the cases), seems surprising regarding recent progress in the management of this complication. The aim of this review is to present the current state of knowledge on venous leg ulcer management, especially compression therapy. Treatment of venous ulcers should be comprehensive and wellorganized, based on modern standards and up-to-date, and should involve elaborated treatment strategies. A thorough diagnostic process followed by adequate treatment may result in marked improvement of the outcomes, with up to 67% healing rate at 12 weeks and up to 81% within 24 weeks. Continuation of therapeutic activities after the ulceration has been healed is reflected by a marked decrease in the recurrence rates, down to 16% whenever the patient is actively involved in the therapeutic process. Furthermore, early diagnosis and appropriate causal treatment may prevent progression of the illness.

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Section: Discussionmentioning

confidence: 96%

The role of compression therapy in the treatment of venous leg ulcers

Mościcka¹,

Szewczyk²,

Cwajda‐Białasik³

et al. 2018

Adv Clin Exp Med

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“…In addition, neuropathy and reduced blood flow to the extremities are common in these individuals. Consequently, wounds tend to heal more slowly, increasing the risk of amputations and death [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of methicillin-resistant Staphylococcus aureus among insulin-dependent diabetic individuals in Brazil

Teixeira

Fortaleza

Souza

et al. 2021

Ann Clin Microbiol Antimicrob

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Background People with diabetes mellitus, especially insulin-dependent diabetic patients, are a risk group for staphylococcal infections. Asymptomatic infection with Staphylococcus aureus is common and favors dissemination of the microorganism, rendering these individuals a source of infection. This study aimed to characterize the resistance profile, clonal profile and sequence type, as well as to analyze the prevalence and risk factors for nasal and oropharyngeal carriage of methicillin-susceptible (MSSA) and methicillin-resistant S. aureus (MRSA) isolated from insulin-dependent diabetic individuals in the city of Botucatu, SP, Brazil. Methods Staphylococcus aureus was collected from the nasopharynx and oropharynx of 312 community-dwelling insulin-dependent diabetic individuals over a period of 3 years (October 2015 to December 2018). The isolates were characterized by susceptibility profiling, detection of the mecA gene, SCCmec typing, and molecular typing by PFGE and MLST. The risk factors associated with S. aureus and MRSA carriage were determined by logistic regression analysis. Results The overall prevalence of colonization with S. aureus and MRSA was 30.4% and 4.8%, respectively. Fifteen of the 112 S. aureus isolates carried the mecA gene; SCCmec type IV was identified in 10 isolates, SCCmec type I in three, and SCCmec type II in two. Among the 15 resistant isolates (MRSA), four were susceptible to oxacillin/cefoxitin by the disc diffusion method and one MSSA isolate was resistant to sulfamethoxazole/trimethoprim. The analysis of risk factors revealed a protective effect of age and lung disease, while lower-extremity ulcers were a risk factor for S. aureus. For MRSA, only male gender was significantly associated as a risk factor in multivariate analysis. Clonal profile analysis demonstrated the formation of clusters among MRSA isolates from different patients, with the identification of ST5-IV, ST5-I, and ST8-IV. Isolates carrying ST398 were identified among MSSA and MRSA (ST398-IV). Conclusion Our findings reinforce the importance of epidemiological studies of S. aureus carriage, especially in populations at high risk of infections such as diabetics. The data suggest widespread dissemination of MRSA in the population of insulin-dependent diabetic patients studied, as well as the emergence of important lineages among these individuals.

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“…Vulnerability to infections by diabetic patients is due to high sugar levels, reduced immune response as well as diminished blood movement to extremities that cause slow wound healing process [23,24]. For example, 25% of diabetic patients with wounds get contagions with antibiotic resistant bacteria, which dictate amputations [24].…”

Section: Statement Of the Problem And Justificationmentioning

confidence: 99%

Phenotypic Profiling of Selected Bacterial Microbes Isolated from Wounds of Diabetic Patients at Jaramogi Oginga Odinga Teaching & Referral Hospital, Kenya

Mamusavu

Kakai

Guyah

2022

JAMB

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Aims: To phenotypically profile selected bacteria microbes, determine antimicrobial resistance patterns and genetic diversity of resistant genes encoding extended spectrum β-lactamases in bacteria isolated from wounds of diabetes mellitus patients at Jaramogi Oginga Odinga Teaching and Referral Hospital (JOOTRH), Kenya. Study Design: A hospital based cross sectional study design. Place and Duration of Study: Jaramogi Oginga Odinga Teaching and Referral Hospital, Kenya between September, 2019 and February, 2020. Methodology: Pus swabs were collected for isolation of bacteria using conventional techniques and serology involving 117 patients. Samples collected were inoculated onto MacConkey agar, pseudomonas agar media (cetrimide) and blood agar plates then incubated aerobically at 37∘C for 18hours to 24hours. Inoculated plates were examined for growth after 24-48 hours. After attaining pure colonies, Gram staining, colony morphology, and biochemical testing were done. Biochemical tests involving Catalase, Coagulase, Indole, Oxidase, Urease, Citrate utilization tests were done to identify specific bacterial species according to microbiological standard procedures. Results: The results of analysis showed that the prevalence of Gram positive cocci isolated from diabetic wounds was 34.2% while the prevalence for Gram negative rods was 65.8%. The biochemically profiled bacterial microbes were S. aureus, E. coli, P. aeruginosa, K. pneumoniae and Proteus species. S. aureus was the most commonly isolated bacteria with a prevalence of 34.2%. P. aeruginosa had a prevalence of 24(20.5%), K. pneumoniae 22(18.8%), Proteus species 18(15.4 %) and E. coli 13(11.1%). More importantly, the prevalence basing on chi-square results was significantly associated with education level, age, smoking habit, patient setting, drug uptake and hospital visit at 5% level of significance (). Conclusion: Diabetic patients with wounds at JOOTRH, Kenya are more exposed to Gram negative rods infection. The most prevalent Gram negative rod was P. aeruginosa with Its prevalence associated with the patient’s education level, smoking habit, patient setting, irregular hospital visit and adherence to taking of prescribe antibiotics regularly. Therefore, JOOTRH, Kenya healthcare providers are urged to initiate wound infection preventive measures that may include awareness campaigns on the importance of wound management, regular hospital visits, stopping smoking and regular uptake of prescribed drugs.

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Randomized clinical trial and economic analysis of four-layer compression bandaging for venous ulcers (Br J Surg 2003; 90: 794-798)

Cited by 4 publications

References 3 publications

The role of compression therapy in the treatment of venous leg ulcers

The role of compression therapy in the treatment of venous leg ulcers

Molecular characterization of methicillin-resistant Staphylococcus aureus among insulin-dependent diabetic individuals in Brazil

Phenotypic Profiling of Selected Bacterial Microbes Isolated from Wounds of Diabetic Patients at Jaramogi Oginga Odinga Teaching & Referral Hospital, Kenya

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