Randomized clinical trial comparing decellularized bovine ureter with expanded polytetrafluoroethylene for vascular access

Chemla, Eric S.; Morsy, Mohamed A.

doi:10.1002/bjs.6434

Cited by 66 publications

(53 citation statements)

References 22 publications

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“…2; [1–6]). There was little evidence of cellular residue on the surfaces of the matrices in groups IV and V, however, a small amount of cell residue was visible on the surfaces of the scaffolds in groups I, II and III.…”

Section: Resultsmentioning

confidence: 99%

“…In the experimental groups, infiltrations of host cells into the grafts were observed (Fig. 3; [2–6]). Especially for groups II and V, the host cell infiltration was less.…”

Section: Resultsmentioning

confidence: 99%

“…Since then, a series of artificial materials have been used to produce scaffolds for clinical trials [6–9]: Synthetic materials have achieved some success in replacing larger coronary vessels (6–10 mm in diameter) [10]; however, in vessels with diameters <6 mm, thrombotic events have rapidly led to the vessels being closed off [11, 12]. For smaller diameter arteries (typically, 3–4 mm) physicians have almost exclusively relied on autologous vein grafts (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…The most impressive results to date have been achieved by using fully natural TEVGs [16]; however, research to find a suitable extracellular matrix (ECM) scaffold for these types of grafts continues [16]. Some research has reported using porcine, goat and bovine tissue for TEVGs with diameters of 4–6 mm [6, 17, 18]. However, studies on ECMs for use in blood vessels <2 mm in diameter are limited [15, 19–23], and reports on the effectiveness of different decellularization protocols are not abundant enough [20, 24–26].…”

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of small-diameter decellularized scaffolds for vascular tissue engineering in an animal model

Cheng

et al. 2017

BioMed Eng OnLine

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BackgroundThe development of a suitable extracellular matrix (ECM) scaffold is the first step in vascular tissue engineering (VTE). Synthetic vascular grafts are available as an alternative to autologous vessels in large-diameter arteries (>8 mm) and medium-diameter arteries (6–8 mm). In small-diameter vessels (<6 mm), synthetic vascular grafts are of limited use due to poor patency rates. Compared with a vascular prosthesis, natural tissue ECM has valuable advantages. Despite considerable progress in recent years, identifying an optimal protocol to create a scaffold for use in small-diameter (<6 mm) fully natural tissue-engineered vascular grafts (TEVG), remains elusive. Although reports on different decellularization techniques have been numerous, combination of and comparison between these methods are scarce; therefore, we have compared five different decellularization protocols for making small-diameter (<6 mm) ECM scaffolds and evaluated their characteristics relative to those of fresh vascular controls.ResultsThe protocols differed in the choice of enzymatic digestion solvent, the use of non-ionic detergent, the durations of the individual steps, and UV crosslinking. Due to their small diameter and ready availability, rabbit arteria carotis were used as the source of the ECM scaffolds. The scaffolds were subcutaneously implanted in rats and the results were evaluated using various microscopy and immunostaining techniques.ConclusionsOur findings showed that a 2 h digestion time with 1× EDTA, replacing non-ionic detergent with double-distilled water for rinsing and the application of UV crosslinking gave rise to an ECM scaffold with the highest biocompatibility, lowest cytotoxicity and best mechanical properties for use in vivo or in situ pre-clinical research in VTE in comparison.Electronic supplementary materialThe online version of this article (doi:10.1186/s12938-017-0344-9) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

“…In the experimental groups, infiltrations of host cells into the grafts were observed (Fig. 3; [2–6]). Especially for groups II and V, the host cell infiltration was less.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of small-diameter decellularized scaffolds for vascular tissue engineering in an animal model

Cheng

et al. 2017

BioMed Eng OnLine

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“…40 On the other hand, Chemla et al found that both grafts were adequate conduits for HD, the anticipated advantages for SG 100 were not seen in either patency or stability. 41 …”

Section: Biological Conduits For Hemodialysismentioning

confidence: 99%

Current Status of Synthetic and Biological Grafts for Hemodialysis

Patel¹,

Altieri²,

Jindal³

et al. 2011

Hemodialysis - Different Aspects

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From Arteries to Capillaries: Approaches to Engineering Human Vasculature

Fleischer

Tavakol

Vunjak-Novakovic

2020

Adv Funct Materials

111

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From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple scales and cell types. The convergence of bioengineering, materials science, and stem cell biology has enabled tissue engineers to recreate the structure and function of different hierarchical levels of the vascular tree. Engineering large‐scale vessels aims to replace damaged arteries, arterioles, and venules and their routine application in the clinic may become a reality in the near future. Strategies to engineer meso‐ and microvasculature are extensively explored to generate models for studying vascular biology, drug transport, and disease progression as well as for vascularizing engineered tissues for regenerative medicine. However, bioengineering tissues for transplantation has failed to result in clinical translation due to the lack of proper integrated vasculature for effective oxygen and nutrient delivery. The development of strategies to generate multiscale vascular networks and their direct anastomosis to host vasculature would greatly benefit this formidable goal. In this review, design considerations and technologies for engineering millimeter‐, meso‐, and microscale vessels are discussed. Examples of recent state‐of‐the‐art strategies to engineer multiscale vasculature are also provided. Finally, key challenges limiting the translation of vascularized tissues are identified and perspectives on future directions for exploration are presented.

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Randomized clinical trial comparing decellularized bovine ureter with expanded polytetrafluoroethylene for vascular access

Abstract: Both grafts were adequate conduits for haemodialysis and were amenable to repair. Anticipated advantages for SG 100 were not seen in either patency or stability.

Cited by 66 publications

References 22 publications

Preparation and characterization of small-diameter decellularized scaffolds for vascular tissue engineering in an animal model

Preparation and characterization of small-diameter decellularized scaffolds for vascular tissue engineering in an animal model

Current Status of Synthetic and Biological Grafts for Hemodialysis

From Arteries to Capillaries: Approaches to Engineering Human Vasculature

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